Posted by admin on Apr 30, 2021 in |
Medicinal plants are considered to be the most important in the primary health care system of developing countries. The therapeutic properties of a plant depend upon the biochemical compounds present in the plant parts employed in the preparation of a medicine. Trichosanthes dioica Roxb. is being used as popular Ayurveda and Siddha medicine used to treat various diseases. Objective: The objective of this research was to carry out for identification of bioactive compounds from ethanolic extracts of leaf and fruit of Trichosanthes dioica Roxb. by Gas chromatography and Mass spectroscopy (GC-MS). Methods: The air-dried leaves and fruits were powdered and separately extracted with ethanol by using a Soxhlet extractor; then, each of the extracts was subjected to qualitative phytochemical analysis and further subjected to a GC-MS instrument. Results: The result of the qualitative analysis of plant extracts has a wide range of active phytocompounds such as alkaloids, flavonoids, glycosides, phenols, saponins, steroids, reducing sugar, tannins, and terpenoids. The GC-MS analysis, twenty two different phytochemical compounds were identified in T....
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Posted by admin on Apr 30, 2021 in |
Translabial drug delivery system is an attractive approach for drug delivery system possess advantages as a bypass of the first-pass metabolism, prevent from digestive enzymes and rapid action of suitable drugs. The purpose of the current research work is to isolate the biopolymer from Phoenix dactylifera (date palm) and prepare mucoadhesive bio-flexy films loaded with Phenytoin. The isolated biopolymer was subjected to various physicochemical characterization procedures for analyzing the mucoadhesive and mucoretentive properties. The mucoadhesive and mucoretentive properties of isolated biopolymer were analyzed using the shear stress method and the MS mucoretentibility method. The formulated Phenytoin loaded bio-flexy films were evaluated for weight, thickness, folding endurance, swelling index, surface pH, tensile strength, etc. The in-vitro drug release studies were analyzed using the static MS diffusion apparatus. Phenytoin loaded with HPMC and sodium CMC was used as standard film, and then results were compared. The optimized bio-flexy films shows order PD6 > PD5 > PD4 > PD3 > PD2 > PD1 on the basis of percentage release. The percent release...
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Posted by admin on Apr 30, 2021 in |
In recent years, Plants and herbal drugs obtaining from natural resources are again gaining importance throughout the world in maintaining the healthcare conditions of individuals. The regular use of natural sources and plant-derived products throughout the world has increased serious concerns over their quality, safety, and efficacy. Adding to the natural scientific resources and knowledge, the tree Ailanthus excelsa Roxb commonly known as the tree of heaven, belongs to the family Simaroubaceae indigenous to central, south India, and Srilanka. The tree has several uses in medicine as the gum, and bitter, aromatic leaves and stem bark of the tree are reported to have medicinal properties. A variety of active compounds are obtained from the plant, which is used in combating a variety of human illnesses, and it also leads the path to search out new active natural and novel semi-synthetic or synthetic compounds. In the present review, we have tried to explore the latest scientific attributes along with traditional knowledge, therapeutic applications, and future prospects of Ailanthus excelsa...
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Posted by admin on Apr 30, 2021 in |
Objective: To evaluate the effect of some counterfeit anti-obesity drugs that are not licensed by the Ministry of Health. Materials and Methods: 100 male rats were divided into 10 groups. The first group received a normal diet for two months. The second group received a high-fat diet (HFD) for two months; the third group received HFD for one month then returned to a normal diet. The remaining seven groups received HFD for one month then treated with Orlistat, Turbo slim (dose 1), Turbo slim (dose 2), African mango (dose1), African mango (dose 2), Slim factor (dose 1), and Slim factor (dose 2) respectively for an additional one month. Bodyweight, glucose, insulin, leptin, adiponectin, MCP-1, reduced glutathione, MDA, lipid profile, kidney, and liver functions were measured. Adipose tissue index, atherosclerosis index, HOMA-IR, and QUICKI were calculated. Results: Feeding with HFD induced a significant increase in body weight as well as insulin resistance, serum lipids, serum leptin, plasma MCP-1, and tissue MDA and a significant decrease in serum adiponectin and tissue...
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Posted by admin on Apr 30, 2021 in |
The present study aimed to examine the anti-hypertensive constituents present in Nardostachys jatamansi. Crude solvent extracts (dichloromethane; ethyl acetate; methanol, and water) of this plant rhizomes based on the difference in polarity were prepared and tested for inhibition of angiotensin-converting enzyme (ACE). Preliminary phytochemical analysis showed bioactive compounds such as alkaloids, flavonoids, carbohydrates, triterpenoid, glycosides, saponin, and tannins in different extracts. Ethyl Acetate extract has shown better results with 93% inhibition at 100 µg concentration as compared to other solvent extracts. Fractionation of ethyl acetate extract over silica gel column chromatography with hexane and ethyl acetate under gradient elution resulted in six fractions. However, on purification of the ethyl acetate extract, ACE inhibition activity diminishes with only 19.03 to 47.35% inhibition for the purified fractions. Nardostachys jatamansi can be used to treat hypertension-related disorders, and ethyl acetate extract can be further investigated to identify potent molecules that work in a synergistic...
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