Posted by admin on Dec 31, 2021 in |
The purposes assigned to this work are the phytochemical screening of certain phytoconstituents, the estimation of the antioxidant and antibacterial activities of extracts of Azadirachta indica A. Juss. The selective extracts obtained from the aqueous decocts were used to establish the chromatographic profile of the various extracts. As for the crude aqueous extracts, they were used to carry out the tests by color reactions to evaluate their antioxidant potential as well as their antibacterial activity against 12 strains. Phytochemical screening revealed the existence of a few bio-important phytoconstituents. The median effective reduction concentration (CR50 = 0.10 mg / mL) demonstrated the antioxidant efficacy of trunk bark decocted (ET) vis-à-vis DPPH, compared with vitamin C (CR50 = 0.006 mg / mL), the reference antioxidant. Also, the extracts, in particular ET, exhibited almost bactericidal activity against the strains tested with the exception of Pseudomonas aeruginosa 469 UB / 20 CNRa. Both the antioxidant and the antibacterial activity of the plant vary depending on the type of extract, organ and bacterial...
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Posted by admin on Dec 31, 2021 in |
A model of ascending Urinary tract infection (UTI) in rats was developed to study the significance of antibacterial activity of Sphaeranthus indicus L. and compared with standard antibiotic ofloxacin as a positive control. This plant used in folk medicine as a remedy for urinary tract infections is belong to Asteraceae family. Outbred female wistar rats were used throughout the study and Escherichia coli was used as pathogen isolated from the urine of patients suffering from urinary tract infections. Methanolic extract (300 mg/mL) and aqueous extract (300 mg/mL) of Sphaeranthus indicus were administered orally for 15 days. After 15 days of treatment of the infected rats with herb extract, bacterial count in the urine, immunoglobulin G and M levels were estimated, and his pathological changes of kidney, liver, and urinary tract were observed. In the disease control group bacterial infection has increased than that of the normal control group. In the treated group with aqueous extract (300 mg/mL) & methanolic extract (300 mg/mL) bacterial count has decreased considerably. There was...
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Posted by admin on Dec 31, 2021 in |
Introduction: Femur is the key bone among the skeletal remains to determine sex for anatomists, anthropologists, and forensic experts. In the present study, we considered most of the parameters to determine sex from the femur. Methods: We studied eighty-four undamaged, intact femora of unknown sex. The present study were carried out in S. C. B. Medical College Cuttack from December 2019 to April 2020. The parameters, like maximum length, maximum breadth, head circumference, mid-shaft circumference, and vertical diameter femur head, were measured by a goniometer and verniers caliper. Results: From each femur above-mentioned parameters were recorded, and the details were obtained about the mean, Standard Deviation, percentage, and p-Value. Then these details were compared with the findings of other studies to conclude. Conclusion: These measurements show the values are higher in males than females and were statistically highly significant between males and females with a p-value...
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Posted by admin on Dec 31, 2021 in |
Objective: The objective was to study drug-drug interaction between Lornoxicam and oral hypoglycemic agents in normal and Streptozotocin-induced diabetes in rats. Material and Method: The protocol was blueprinted in two phases. In the first segment, the influence of Glibenclamide (0.7mg/kg/p.o.) and Glipizide (1.05mg/kg/p.o.) once daily on blood glucose levels in normoglycemic rats were studied and then the influence of Lornoxicam (1.64 mg/kg/p.o. once daily) pre-treatment on the hypoglycemic activity studied. Along with, the influence of Lornoxicam treatment for seven consecutive days (per se effect) on blood glucose levels was also studied in normoglycemic rats. In the second phase of the study, Streptozotocin-induced diabetic rats were used to assess the influence of Lornoxicam pre-treatment on Glibenclamide and Glipizide induced hypoglycemic effect in pathophysiological conditions. Blood samples were collected at accepted hiatus of 0.0, 0.5, 1.0, 2.0, 4.0, 8.0, 12.0, 18.0 and 24.0 h subsequent to drug treatment. All blood samples were evaluated for plasma glucose by the glucose oxidase peroxidase method (GOD/POD). Results: The findings suggested that Lornoxicam influences the hypoglycemic action of...
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Posted by admin on Dec 31, 2021 in |
Currently, oral drug delivery and parenteral drug delivery are used for the treatment of various diseases. In the oral drug delivery system, due to the first-pass metabolism and acidic environment of the gastrointestinal route, the drug exposes to acids and enzymes present in the gastrointestinal tract, which may lead to degradation of the compound, which ultimately results in poor bioavailability of the molecule. On the other hand, the parenteral drug delivery system has its own disadvantages as it is invasive and needs skilled personnel for administration. To overcome these problems, the transdermal drug delivery system is introduced as a novel approach, and recently there is tremendous interest in transdermal drug delivery systems. A transdermal patch is a medicated adhesive patch winch that is placed onto the skin to deliver the appropriate dose of the drug through the skin and directly into the bloodstream. In this, transdermal patches are prepared for drug penetration through the skin layer (Stratum corneum barrier). To avoid the stratum corneum barrier, the microneedle-based transdermal drug...
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