Posted by admin on Oct 31, 2022 in |
Spices are herbs used as flavoring, aromatic, and coloring agents. The culture of various countries even involves the incorporation of spices daily, not just for their culinary potential but also for the health benefits they provide. Many age-old scriptures suggest incorporating the Indian System of Spices in everyday meals to counter many diseases and keep them at bay. The fact that dietary factors play an important role in the treatment as-well-as prevention of diseases makes it all the more important to conduct research and provide scientific evidence regarding the use of culinary species as potential agents with a therapeutic effect. Such culinary spices have various active phytoconstituents, which can have many therapeutic effects and also prove to be great antimicrobial, antidiabetic, anticancer, etc. Generally, most of allopathic drugs are taken individually. Still, unlike them, the spices are consumed in combinations to provide a possible synergistic effect that would be advantageous to us. Also, due to lesser chances of side effects and incorporation of mechanisms to treat any disease right...
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Posted by admin on Oct 31, 2022 in |
Aegle marmelos (L.) is an important plant with various medicinal values. It is commonly known as Bael (or Bel), belonging to the family Rutaceae. Bilwa is used to cure a variety of diseases. All the parts of this plant-like fruit, leaves, bark, stem and roots are used in different diseases, a variety of alkaloids are found in it. Compounds purified from the fruit have been proven to have biological potential against several diseases like diabetes, gastric ulcer and have lipid regulating properties. This review emphasizes the prospective applications of Aegle marmelos (L.) in the pharmaceutical field due to its extensive pharmacological...
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Posted by admin on Oct 31, 2022 in |
Manuscript aims to furnish glimpse on coating processes (CoPr). The coating is the process of applying coating materials (CoMa) onto the substrate surface (S-S). With time and space dimension of CoPr, that upraised as sugar-coating (S-C) expanded to film-coating (F-C) and specialized one. Lengthy and wearisome processing and skilled operators issues inherited to S-C spring-up F-C and its improvement from non-aqueous F-C to aqueous film-coating (AF-C). Non-aqueous film-coating processes (F-CP) make use of a volatile organic solvent (VOS) while AF-C processes uses aqueous solvent (AS), as a solvent system for coating formulations (C-F). VOS is preferred over AS in F-CP, and momentum for using AS has been accelerating from past few decades. Issues from VOS’s use upraised relating to safety; worker hygiene & safety; toxicity; environmental pollution; etc. These upraised issues intensified, thus, nowadays, AF-C processes are replacing VOS-based F-CP. Later on, finding the novelty of coating and CoPr thru coating of particulates became another dimension of expansion. This involves modification and/or alteration in innate properties of particulates, chemically...
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Posted by admin on Oct 31, 2022 in |
The pandemic COVID-19 caused by Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) has killed millions of human beings throughout the world and attaining natural immunity against this virus is the best remedy. Consumption of nutraceuticals having antiviral and immune-boosting ingredients is the natural way to fight against it. The main objective of the present study was to evaluate the anti-SARS-CoV-2 activity of phytochemicals from Syzygium aromaticum and identify lead molecules through an in-silico approach. To determine anti-SARS-CoV-2 activity, 249 phytochemicals from Syzygium aromaticum (Clove) were docked with each of the four therapeutic targets namely Spike protein (SP), Angiotensin-Converting Enzyme-2(ACE2), Main protease (Mpro) and RNA-dependent RNA polymerase (RdRp). Spike protein and ACE2 have a key role in viral entry into the human host and Mpro and RdRp have a key role in viral multiplication. The docked molecules with minimum binding energies ≤ -6 kcal/mol were considered active/hit molecules. The total number of hits obtained in the order of merit was 46, 51, 60, and 150 against RdRp, spike protein, Mpro, and...
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Posted by admin on Oct 31, 2022 in |
Acyclovir has a ratified antiretroviral effect for Herpes simplex virus type 1 (HSV-1), HSV-2, Varicella zoster virus (VZV), Herpesvirus simiae and to a minor extent, Epstein-Barr virus (EBV). The oral bioavailability of acyclovir is indigent, with only 15%–30% of the oral formulations’ vitality absorbed. To baffle the issue of insignificant bioavailability, acyclovir was formulated into biodegradable gelatin nanoparticles through a double desolvation method adopting gelatin, acetone as desolvating agent, and glutaraldehyde as a cross-linking agent. Optimization was imposed through design expert software whereby the aftermath of gelatin polymer concentration (X1) and glutaraldehyde-crosslinking agent (X2) was studied on particle size (Y1), zeta potential (Y2) and entrapment efficiency (Y3). The optimized formulation (F9) demonstrated a particle size, zeta-potential and maximum entrapment efficiency of 139.87 nm -32.67mv and 91.23%, respectively. The rate of drug release from acyclovir-loaded gelatin nanoparticles ensued from first-order kinetics, and Korsmeyer-peppas plots established the mechanism of drug release from nanoparticles. The release exponent (n) value indicating that drug release embellished by quasi-fickian diffusion transport. The in-vivo pharmacokinetic parameters such as...
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