Posted by admin on Oct 31, 2022 in |
A hydrogel with strongly cross-linked hydrophilic polymer chains makes up the majority of nanogels, which are essentially nanoparticles. Several hydrophilic functional groups in hydrophilic polymers enable nanogels to absorb large amounts of water. Incredibly stable, adaptable, and responsive to sensory influences, nanogels have the potential to be a safe and effective medication delivery vehicle for biological products. Peptides, hormones, DNA, vaccines, chemotherapeutic treatments, and a wide range of pharmaceutical goods can all be delivered using these devices. There are several varieties of nanogel-based drug delivery systems, varied techniques of production, processes of drug release, and commercially available formulations. The presentation emphasizes the various types of nanogel based drug delivery systems, preparation methods, drug release mechanisms, marketed preparations, and their various applications in the medical...
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Posted by admin on Oct 31, 2022 in |
Aim of this study was to generate 3D models of protein drug targets in Erysipelothrix rhusiopathiae by homology modelling. E. rhusiopathiae causes swine erysipelas disease that has great economic impact on the pork industry. Bioinformatic databases such as Uniprot KB, Drug Bank, PMDB and online tools such as BLASTp, SWISS Model and Ramachandran plot analysis and software such as Autodock4 and Pymol were used to perform this study. Among 4153 proteins reported from Erysipelothrix rhusiopathiae, 396 proteins were identified as potential drug targets. These 396 proteins were employed in homology modelling through the SWISS Model. Total of 131 homology structures with the Ramachandran favorable score above 95% were considered as reliable drug targets and were submitted to PMDB online database. The modelled proteins were subjected to protein-ligand docking analysis with standard antibiotics such as Ribostamycin, Cefalotin, Pefloxacin, Penicillamine, Artenimol, Cycloserine against their respective drug targets. Among these antibiotics Ribostamycin was identified as a potent drug against the Protein Disulphide Isomerase with a significant binding energy of -7.35Kcal/mol with formation...
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Posted by admin on Oct 31, 2022 in |
Single Cell Protein (SCP) refers to the dead, dried cells of various microbes, including bacteria, yeast, algae, and fungi. This type of biomass can be obtained from economically cheap substrates like agro-wastes as a non-conventional proteintious source for human or animal feed. The bioconversion of Darjeeling mandarin peels into single-cell protein (SCP) was performed using Aspergillus niger and Aspergillus oryzae, by submerged fermentation. The study revealed that supplementing Darjeeling mandarin peels with inorganic nitrogen and glucose as carbon sources improved the fungal biomass and single-cell protein production. Aspergillus niger showed the highest biomass and protein yield of 2.53±0.005gm/l and 1.25 gm/l or 43.57±0.00%, respectively. The present study revealed that fungal biomasses had shown crude fat (ranging from to1.16gm/l), crude fiber (ranging from 0.06±0.001to1.97 gm/l), and total genomic DNA content (from 1.85±0.001-2.20±0.001%). Maximum ash content was observed by A. niger biomass in GMPM (3.89%). A. niger converted sugar 71.4% to yield biomass. A. niger and A. oryzae were useful for producing fungal biomass from Darjeeling mandarin...
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Posted by admin on Oct 31, 2022 in |
Numerous therapeutic and prophylactic interventions are tried being developed and tried for COVID-19, from repurposed drugs, antivirals to immunotherapy including convalescent serum, vaccines and monoclonal antibodies to reduce the global burden of the disease. Vaccine-derived immunity develops over time and remains as the primary option for prophylaxis. Administration of neutralizing mAbs is an immediate and passive immunotherapy with the potential to reduce disease progression, hospitalizations and death. Antibody-based treatments are likely to be more effective if used during the early phase of the illness. Casarivimab together with Imdevimab, holds emergency use authorizations in several countries globally and in India. This review discusses the mechanism of action, current clinical indications, dose, use with other medications and vaccines, duration of protection, protection against variants and evidence of Casarivimab and Imdevimab monoclonal antibody cocktail therapy for mild to moderate COVID-19...
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Posted by admin on Oct 31, 2022 in |
Chronic diseases such as cardiovascular, cancer, and respiratory diseases are being increased. Reactive oxygen species, free radicals, and oxidative stress play a major role in aggravating these diseases. Plants and plant-derived compounds have shown a greater potential in combating the detrimental effects of free radicals and other toxic agents. The current research work has been done on the leaf and bark of Saraca asoca to evaluate its free radical scavenging antioxidant properties. The antioxidant activities of Saraca asoca methanolic extract were assessed by employing ABTS Radical Scavenging Capacity, DPPH, Superoxide Radical, Hydroxyl Radical, Lipid Peroxidation, and Nitric Oxide Scavenging Ability. The leaf and bark extract results assessed against ARSC, DPPH, Superoxide, Hydroxyl, Lipid Peroxidation, Nitric Oxide, FRAP exhibited remarkable IC50 values in a concentration-dependent manner, thus proving it as a potential antioxidant. The results of the present comprehensive analysis demonstrated that Saraca asoca leaf and bark extract exhibited excellent antioxidant activities and could be exploited for further nutraceutical and medicinal applications effective in treating many...
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