Posted by admin on Aug 31, 2022 in |
Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune disorder that permanently damages and disables the joints if left untreated. Much research is being carried out; however, any detailed information that could impart knowledge of all the major aspects in an undivided form is still lacking. This review attempts to revive the existing knowledge on RA and provides comprehensive data and current information about the classification criteria for the diagnosis of rheumatoid arthritis and treatment protocol for the management of Rheumatoid arthritis. Early and accurate diagnosis is essential as it can slow down the progression of the disease, permanent joint damage and disability in up to 90% of RA patients. This article also focuses on various diagnostic modalities which help in the diagnosis of RA, and synthetic medicines available for the cure of RA. It provides a section about non-pharmacological and herbal treatment options available for the management of Rheumatoid...
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Posted by admin on Aug 31, 2022 in |
Telmisartan has a strong, nonpeptide antagonist with long-acting angiotensin II type-1 (AT 1) receptor to treat essential hypertension. It is classified as a BCS class II medication, meaning it has poor solubility and high permeability. Because of their capacity to minimise toxicity and change bioavailability, niosomes are becoming increasingly essential in medication delivery. Telmisartan-loaded niosomes were created by adjusting the span 60 and cholesterol ratios in a thin film hydration technique and then assessed for vesicles size, entrapment efficiency and drug release. Batch N6 fulfilled all the requirements and hence it was selected as an optimized formulation of noisome. This investigation supports the use as carriers for developed niosomes to enhance the administration of Telmisartan by oral...
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Posted by admin on Aug 31, 2022 in |
Objective: This study gives an overview of prescribing pattern of antibiotics in children in our tertiary care teaching hospital. Methods: It is a prospective observational study carried out on paediatric in-patients with a sample of 160 patients based on age, inclusion, and exclusion criteria for a period of 6 months. The patient’s data were collected using a patient case record form and the data analysis was done. Results: Out of 160 patients data that were collected, the results showed that the majority of gender which were admitted to the hospital were male children 89 (55.62%), and many were from the age group of early childhood (6-12 years) 64 (40.00%). Respiratory tract infections were the diagnosis most commonly analyzed; overall, 236 prescribed antibiotics, cephalosporins 121 (51.21%) were commonly evident, and parenteral 161 (68.22%) – route of administration was observed to be followed more than other routes. Conclusion: Antibiotic Resistance is a worrisome factor worldwide, challenging treatment regimens. Surgeons & Physicians worldwide find it difficult to cope with the increased resistance...
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Posted by admin on Aug 31, 2022 in |
In this research work, numerous molecules that have substituted triazole phthalazine derivatives were obtained using phthalic anhydride as a starting material. It was taken as starting material that gave reaction in the precence of different conditions with different substituted benzoyl chloride that yielded 6 chloro-3 substituted 6a, 10 a-dihydro-[1, 2, 4] triazolo [3, 4-a] phthalazine derivatives (I-V). These intermediates further reacted with substituted benzaldehyde and yielded 4-2-3-Substituted – 6a, 10 a-dihydro-[1, 2, 4] triazolo [3, 4-a] phthalazin-6-yl) substituted hydrazinyl derivatives (VI-X) which were further react with triethyl amine and acetyl chloride yields (XXI-XXX). The antidiabetic effect was investigated using oral glucose tolerance test in normal and non-insulin-dependent diabetes mellitus (NIDDM) in STZ-rat model. In this model Roziglitazone taken as a standard drug for this pharmacological...
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Posted by admin on Aug 31, 2022 in |
Arthritis is a joint disorder which is characterized by inflammation. A joint function to move the body parts connected by its bones. Arthritis means inflammation of one or more joints. The study investigates the anti-arthritic activity in rodents by use of in-vivo parameters Paw volume, Knee diameter, Paw thickness, Paw oedema, and body weight. Some biochemical parameters were also done, such as SGOT, SGPT, Total protein estimation, ESR rate, Haemoglobin level Histopathological investigation. Animals serving as arthritic control received 2% formaldehyde 0.1ml throughout the study; while the animals in the standard group received 10mg/kg of Indomethacin. The animal in the test group received 240mg/kg extract once daily by oral route. The results revealed that preliminary phytochemical screening of Salix alba extract, revealed the presence of following phytoconstituents i.e., alkaloids, flavonoids, terpenoids, tannins and proteins. The proximal analysis of extract was found ash value, acid value and moisture content. Histopathology was represented, Normal control group joint normal synovial membrane and joint space, Negative control group Arthritis characterized by the presence...
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