Posted by admin on Aug 31, 2022 in |
Purpose: Insulin-like growth factor-1(IGF-1) is an important growth hormone that promotes the anabolic effect and linear growth in adults and children. This study aimed to assess serum levels of IGF-1 in healthy Syrian children during Syrian conflicts. Materials and Methods: This study was approved by Al Wataniya Private University ethical committee. In total, 83 children, 49 males and 34 females (3-16 years) were enrolled. Demographic data were registered after obtaining written informed consent from children’s families. Venous blood samples were drawn from children to measure serum IGF-1 levels. GraphPad Prism5.0 was applied to analyze data. Pearson and Mann-Whitney tests were used. Results: The averages of age, weight, height, and body mass index were 6.86±2.69 years, 20.36±7.8 kg, 112.56±16.4 cm, and 15.5±1.7 kg/m2, respectively. The average level of IGF-1was 85.44±60 ng/ml. A third of participants had IGF-1 levels below the normal index for their ages, and there was a significant difference in IGF-1 levels and height between these children and the others. 22.8% of participants had short to limit short...
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Posted by admin on Aug 31, 2022 in |
Selective and novel method has been optimized to evaluate Abacavir, Dolutegravir and Lamivudinein bulk and formulation by HPLC. The principle analytes were eluted with the conditions of the mobile phase having the Ethanol: Ethyl acetate (80:20, % v/v) using the Lichrosphere RP C8 column (Phenomenex, USA (250 x 4.6 mm, 5μ) analytical column with the 1.0 ml/min flow rate and 10µl sample volume at 260 nm in UV detector. The retention times of Abacavir, Dolutegravir and Lamivudine were 2.31 min, 3.120 min and 4.59min with a total run time of 6 min. The curve indicates correlation coefficient (r2) was superior by having a value nearer to 1.000 with a linear range of 40 µg/ml-130.0 µg/ml for Abacavir, Dolutegravir and Lamivudine. The correlation coefficient (r2) 0.9971for Abacavir, 0.9979 for Dolutegravir and 0.9947 for Lamivudine were found. The LOD and LOQ for the Abacavir, Dolutegravir and Lamivudine were found at 1.40 µg/ml, 3.01µg/ml, 5.84µg/ml, and 4.25 µg/ml, 9.12 µg/ml and 17.71 µg/ml. The developed method was applied for the bulk and...
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Posted by admin on Aug 31, 2022 in |
As a source of medicine, plants have always been exceptional. Ayurveda and other Indian texts discuss the use of plants to treat a variety of human illnesses, including cancer and diabetes. Thousands of plant species in India, which number in the tens of thousands, are thought to have medicinal use. Recent studies on plants described in historical writings or used to treat sickness have been carried out. An Indian medicinal plant of the Bignoniaceae family is Stereospermum suaveolens DC. It has traditionally been used as an analgesic, liver stimulant, astringent, wound healer, and antiseptic. Dashamularishta has the roots of this plant as one of its components. More research into the plant’s medicinal properties has been done than the isolation of its active components. Stereospermum suaveolens have been used to treat fevers and brain disorders for their antibacterial, antiprotozoal, and anti-inflammatory properties. An in-depth look at the chemistry and pharmacology of Stereospermum suaveolens is presented in this...
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Posted by admin on Aug 31, 2022 in |
Neuropathic pain (NP) is a chronic debilitating condition that affects all dimensions of health. Though pharmacological therapy is the main treatment of varied neuropathic pain conditions, not all neuropathic pain conditions respond well to drug therapies. Therefore, under-utilized non-pharmacological strategies were tried and implemented in chronic neuropathic pain subjects to provide adequate pain relief and restore functionality. This study aimed to assess the awareness of non-pharmacological interventions in neuropathic pain and to determine the attitude and practice towards the actual implementation of non-pharmacological modalities in attenuating pain symptoms of NP subjects. It was a Prospective, Observational study conducted on 100 OPD subjects of either gender aged 18-65 years with newly diagnosed chronic neuropathic pain conditions who agreed to participate in the study from January 2019 to June 2020 in the Pain Super-specialty clinic at Kempegowda Institute of Medical Sciences, Bangalore. Data were collected using a purposive sampling method, using a Self-administered, 14-item Questionnaire. The mean age of the study subjects was 44.68 years. 60.0% were aware of the existing...
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Posted by admin on Aug 31, 2022 in |
Doravirine, Lamivudine, and Tenofovir Disoproxil Fumarate belong to the class of anti-viral drugs and have been widely used in the treatment of HIV-I infection. Doravirine is a novel non-nucleoside reverse transcriptase inhibitor used in the combination of Lamivudine and Tenofovir Disoproxil Fumarate to effectively treat HIV/AIDS by overcoming the common resistance mutations without any possible drug interactions when co-administered. A literature review has reported few methods for the simultaneous estimation of Doravirine, Lamivudine, and Tenofovir Disoproxil Fumarate in combination with other antiviral drugs. The present investigation aimed to develop a simple, rapid, economical and stable indicating RP-HPLC method for the simultaneous estimation of Doravirine, Lamivudine and Tenofovir Disoproxil Fumarate in the pharmaceutical dosage form. The chromatographic separation was achieved on Kromasil C18 column with the dimensions of 250 x 4.6 mm, 5µm particle size, and maintained at 30 ˚C at a wavelength of 260nm. A combination of buffer (0.1% OPA) and Acetonitrile as mobile phase has optimized the method for efficient separation of drugs. Doravirine, Lamivudine and Tenofovir Disoproxil...
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