Posted by admin on Jul 31, 2022 in |
Background: Pain is a common symptom having huge public health importance. Conventional analgesics relieve pain effectively but cause various unwanted side effects. Hence the search for a novel analgesic with favourable risk-benefit profile is essential. Objectives: The current study was undertaken to investigate the analgesic activity of the ethanolic, hexane and chloroform extracts of sesame seeds by thermal heat method in Albino mice. Methods: The mice were divided into 5 groups. Group 1 was administered normal saline. Group 2 was given aspirin (50 mg/kg). Groups 3 to 5 were administered the various Sesame seed extracts (ethanolic, hexane and chloroform) at the doses of 100, 150 and 200 mg/kg, respectively. All drugs were administered orally. Analgesic activity was evaluated by hot plate method. Results: The ethanolic extract of Sesame seed at the dose of 100 mg/kg and 150 mg/kg exhibited significant analgesic activity at 120 and 180 minutes, whereas at a dose of 200 mg/kg it exhibited activity even at 60 minutes. The maximum analgesic effect was shown at 120...
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Posted by admin on Jul 31, 2022 in |
Marsdenia tenacissima (MT), a traditional herbal medicine (Family Asclepiadaceae), during the past several years, there has been increasing interest in the uses of various medicinal plants from the traditional system of medicine for the treatment of different ailments. The present review highlights the pharmacognosy, phytochemistry, and pharmacological study of Marsdenia tenacissima. In this, pharmacognostical studies are concerned with the determination of physicochemical constants like ash value, extractive value, pH, and loss on drying. It is used in various pharmacological activities like anti-cancer, anti-diarrheal, anti-inflammatory, Analgesic, Antioxidant, Antidiabetic, Antihyperlipidemic, and Anti-arthritic activities. Marsdenia tenacissima has been used in traditional medicine as a household remedy for various...
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Posted by admin on Jul 31, 2022 in |
Background: Sepsis leads to approximately 11 million deaths annually. Objectives: We studied the effectiveness of using a combination of intravenous hydrocortisone (50mg QID), Ascorbic Acid (1.5g QID), and Thiamine (200mg BD) (HAT) to reduce mortality among septic patients compared to a historical control group. Materials and Methods: This retrospective, observational study was conducted between January 2016 – February 2018. Our hospital mortality for septic shock is 55%. According to published literature, hospital mortality decreased from 40.4% to 8.5% with the HAT protocol. To detect a 31.9% mortality difference with 95% confidence and 80% power, a minimum sample size of 27 patients would be required in each group. We included 62 patients (31 per group) with septic shock. In the experimental group, patients in septic shock received the HAT drugs within 6 hrs and continued for 4 days. They were compared with a propensity score-matched historical control group. Results: Nineteen (61.29%) and twenty-seven (87%) patients in the control group received steroid and vitamin supplements (non-Vitamin C), respectively. The mortality was...
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Posted by admin on Jul 31, 2022 in |
Hypertrophic cardiomyopathy (HCM) is a genetic disorder that is characterized by left ventricular hypertrophy unexplained by secondary causes and a nondilated left ventricle with preserved or increased ejection fraction. It is commonly asymmetrical, with the most severe hypertrophy involving the basal interventricular septum. The histological features of HCM include myocyte hypertrophy and disarray, and interstitial fibrosis. Hypertrophy is also frequently associated with left ventricular diastolic dysfunction. It is also an important cause of sudden cardiac death, particularly in adolescents and young adults. Non-sustained ventricular tachycardia, syncope, a family history of sudden cardiac death, and severe cardiac hypertrophy are major risk factors for sudden cardiac death. Atrial fibrillation is also a common complication and is not well tolerated. Mutations in over a dozen genes encoding sarcomere-associated proteins cause HCM. MYH7 and MYBPC3, encoding β-myosin heavy chain and myosin-binding protein C, respectively, are the 2 most common genes...
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Posted by admin on Jul 31, 2022 in |
Stress is a complicated process that affects everyone differently. When the body is exposed to stressors, it initiates a series of coordinated responses called “stress responses,” which include behavioral changes, immunological regulation, hormone release, and various physiological changes. Stress is the physiological response to risk or pressure, and it displays physically as fatigue or energy loss and psychologically as irritation or tension. Chronic stress or despair, which are issues of unmet health care need, may develop if they remain untreated. Treatment and preventative strategies that are based on scientific evidence are required. Current medicines show a therapy gap. The majority of medications solely address psychological or physical stress symptoms. Furthermore, psychotropic medicines, which are occasionally given for stress, frequently have undesirable side effects and cause danger of overuse. Pharmacological therapy should provide advanced care for all stress symptoms while also having a favourable safety profile. One of the most effective techniques for dealing with stress is to eat stress-relieving and nutrient-reducing meals. The term “nutraceutical” is composed up of...
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