Posted by admin on Jun 30, 2022 in |
This manuscript aims to figure out updated information on the dry coating of powder (DCP). In pharmaceutical processes, the inevitable is handling of fine and ultra-fine particles (FUFP). Their higher surface area associated surface and surface attributes contribute chiefly to exhibited complex phenomenon like bulk behaviors, physicochemical property, performances and functionalities of pharmaceutical importance, and many others. Nowadays particle engineering techniques are extensively exploited to modify surface and surface attributes of FUFP to find their worthy applications and new functionalities. Among available diverse techniques for particle engineering DCP is advocated as a worthy and efficient one. The DCP is considered to have multidisciplinary applications in drug development and drug delivery. Process basis of DCP calls for attaching and/or fixing the particles of coating material (PCM) or guest particle (GuP) onto the substrate/core particle (S/CP) or host particle (HoP). Fixing/ attaching the PCM onto HoPs mandates their interaction that may be mechanical, chemical, thermal, electro-chemical and many others. Scientific literature and patents are evidencing diverse processes and methods for interacting...
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Posted by admin on Jun 30, 2022 in |
In today’s world, the medicine enterprise is among the quickest developing companies because of outbreaks of diverse sicknesses and antimicrobial opposition of diverse microbes towards typically utilized antibiotics. The control of diverse sicknesses and the traditional topic of treatment along with Ayurveda and home-based treatments also carries out a vital function within the part. Consequently, using an idea from home-based treatments and Ayurveda, these studies was created and done to show the anti-bacterial usage of Nyctanthes arbor-tristis leaves scientifically. A realize that is relative been achieved to judge the anti-bacterial pastime of Nyctanthes arbor-tristis towards Staphylococcus aureus, Streptococcus pyogens, Pseudomonas aeruginosa and Salmonella typhi from decided on leaves of Nyctanthes arbor-tristis from unique geographic places. The leaves of the plant are seen to function as the maximum green component with anti-bacterial pastime towards diverse pathogens analyzed. The anti-bacterial pastime of methanolic and chloroform extracts is analyzed with all the help of utilizing the disk diffusion technique. The ethanol extract of leaves has a greater pastime that is anti-bacterial chosen...
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Posted by admin on Jun 30, 2022 in |
The incidence of multiple antibiotic-resistant Salmonella spp. isolates in randomly collected potable water samples from 70 different slum area sites of Bhopal City, M. P. India, were investigated through a molecular approach.BSA media was used for isolation and CFU count of Salmonella spp. The DNA of representative Salmonella spp. Colors of each water sample were subjected to PCR to detect Amp, cmlA and tetA genes with standard PCR protocol with annealing at primers specific temperature for 1 minute 30 seconds. The presence of the target gene in the PCR product was detected on 1% agarose gel. An in-vitro antibiogram study was done to check the phenotypic antibiotic resistance. A total 74.29% of samples were reported to have a prevalence of Salmonella spp. with 44.19average CFU count and huge standard deviation (σ=28.28). Incidence of Amp, cmlA, and tetA genes is reported to be 67.31%, 36.54%, and 61.54% in Salmonella spp. Isolates from 52 samples which doesn’t coincide with the phenotypic prevalence of antibiotic resistance. 25, 17, and 11isolates showed resistance...
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Posted by admin on Jun 30, 2022 in |
Anxiety is one of the main psychiatric disorders worldwide. Furthermore, it is difficult to find out the patients suffering from various kinds of anxiety diseases. Numerous herbal plants have been utilized to treat the anxiety disease in traditional medical systems for thousands of years because of their safety, efficacy, and effectiveness. The present study was designed to evaluate the anti-anxiety activity of the hydroalcoholic extracts of the leaves of the Achyranthes aspera plant in rodents like mice. The anti-anxiety activity was assessed in swiss albino mice. The leaf of the Achyranthes aspera plant was air-dried and was reduced to coarse powders. The Soxhlet extraction method was used for this anti-anxiety activity. Qualitative phytochemical screening of hydroalcoholic extracts of Achyranthes aspera was carried out. Several models were used to evaluate the anti-anxiety activity of the leaves of the Achyranthes aspera plant: the elevated plus-maze model, the light-dark model, the social interaction model, and the hole board technique. For this, the dose of hydroalcoholic extract p.o. at 300 and 600 mg/kg,...
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Posted by admin on Jun 30, 2022 in |
Furan and Azetidinone have been reported to possess various therapeutic activities, including anti-microbial and anti-cancer activity. Increasing drug resistance and high toxicity to the existing drugs have dictated the need to develop novel, effective agents with different scaffolds. With the perspective of identifying novel anti-cancer molecules, an approach was made to hybridize the different heterocyclic moieties. Thirtynovel Furan-Azetidinone hybrids were subjected to in-silico molecular docking studies to determine the novel molecules’ affinity for the anti-cancer targets. The four most promising derivatives were selected and synthesized based on docking scores. Condensation of ethyl cyanoacetate and o-toluidine at 160-1900C yielded 2-cyano-N-2(methylphenyl) acetamide (1). The reaction between (1) and benzoin yielded 2-amino-N-(2-methylphenyl) 4, 5-diphenylfuran-3- carboxamide (2). A series of Schiff bases ARJJ03 (1-2), were synthesized from (2) by refluxing it with various substituted aromatic aldehydes in ethanol using concentrated sulphuric acid as the catalyst. The title compounds ARJJ04 (1-2) were obtained by the cyclization of ARJJ03 (1-2) with Chloroacetyl chloride in 1, 4-dioxane in the presence of triethylamine. The synthesized derivatives were...
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