Posted by admin on May 31, 2022 in |
Obesity and overweight have recently drawn greater attention due to their central role in the rapid increase of metabolic syndrome disorders. The research pursuit for exploring novel and effective therapeutic alternatives to deal with obesity ailments and oxidative stress has received immense interest. In this study, different solvent fractions of Nigella sativa (N. sativa; Black cumin) seeds were prepared and their phytochemical analysis was done. Among different solvent fractions, the methanolic fraction of N. sativa (MFNS) contained a high level of polyphenols (451.77 ± 0.91 μg/mL) and flavonoids (401.24 ± 0.73 μg/mL). The GC-MS analysis of MFNS showed the presence of several glycosides, oils, and polyphenolic compounds, as mentioned in the results section. The effect of N. sativa seed fractions on inhibition of key digestive enzymes linked to adiposity such as α-amylase, α-glucosidase and pancreatic lipase was evaluated. The free radical scavenging activity of seed fractions was studied through standard antioxidant assays (DPPH and NO). The enzyme inhibitory effect of MFNS for α-amylase, α-glucosidase and pancreatic lipase was 81.47%,...
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Posted by admin on May 31, 2022 in |
At a time where we understand that new drug discovery and development involves significant cost, expensive products and is the slow-paced process, an innovative idea called ‘Drug Repositioning’, which basically means repurposing of old drugs to treat diseases including both common and rare are being increasingly attractive as it provides drug development in a sustainable cost, time efficiently and the product value is also low, making it less risky for pharmaceutical investment. A drug initially marketed as an anti-anginal drug repurposed for erectile dysfunction (Sildenafil/ Viagra) is an important example of landmark evidence in history. Similarly, over the years, several drugs have been successfully repurposed into other drug uses to treat various diseases. In this systematic review article, we have focused on the wholesome idea and methodologies of drug repurposing and its approaches, methods, challenges and strategic advantages over traditional drug discovery in the present...
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Posted by admin on May 31, 2022 in |
This study was designed to evaluate and compare the Antidepressant effect of Ibandronate with Amitriptyline on depression models in albino mice. Eighteen Swiss albino mice weighing 20-25 grams were selected and divided into three groups of six animals each. Group 1: Normal Saline- 0.5 ml, Group 2: Amitriptyline – 39 mg/kg, Group 3: Ibandronate 0.325 mg/kg administered orally every day for 30 days. Animals were subjected to a forced swim test, tail suspension test, and Locomotor activity test on 1st, 10th, 20th and 30th day of the experiment after 1 hour of drug administration. The forced swimming test and Tail suspension test detected the duration of immobility, whereas the Actophotometer test detected the influence of the drug on the Locomotor system. The data reveal that Ibandronate has an antidepressant action that did not differ significantly from Amitriptyline. Ibandronate a Bisphosphonate has shown an antidepressant effect on depression models in albino...
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Posted by admin on May 31, 2022 in |
Ulcerative colitis was defined as a common intestinal infla-mmatory disease characterized by upregulation of pro-inflammatory cytokines and oxidative stress. The leaves of Murraya koenigii and Centella asiatica had been used in traditional medicine to treat the disease. The present study aimed to perform a comparative protective efficacy evaluation between Murraya koenigii and Centella asiatica on acetic acid-induced ulcerative colitis in rats. Rats were randomly categorized into nine groups: control, acetic acid, standard drug, acetic acid + extract of Murraya koenigii (50, 100, 200 mg/kg), and acetic acid + extract of Centella asiatica (50, 100, 200 mg/kg) groups. After 5 days of feeding, colitis was induced in the experimental animal groups by transrectal administration of 1ml of 4% acetic acid. The rats were sacrificed after 24 hr of rectal installation, and their colon tissues were examined. Pretreatment with extract of Murraya koenigii and Centella asiatica significantly reduced colon weight-length, macroscopic scores, histological changes, and upregulated the enzymatic activity of superoxide dismutase (SOD). The above results indicated that oral administration of...
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Posted by admin on May 31, 2022 in |
Aegle marmelos, commonly known as Bael or Bilva, is a traditional tree belonging to the family Rutaceae with enormous value in ethnobotany, Ayurveda, and has been used since time immemorial for its spiritual significance as an offering to Lord Shiva while worshipping. Looking at its religious perspective and medicinal benefits, people have conserved trees of Bael in sacred groves. It is a sub-tropical tree and grows wildly in the dry, dry dipterocarp and mixed deciduous forests on the plains and hilly regions. Researchers have used and studied almost all the parts like root, bark, fruit, leaves, and seeds of this significant tree because of the varied phytoconstituents isolated from them, like alkaloids and terpenoids, amino acids, fatty acids, coumarins, etc. Substantial experiments were conducted on Aegle marmelos owing to many phytoconstituents found in it and they were found to exhibit potential therapeutic responses in many pharmacological activities like anti-diabetic, anti-hyperlipidemic, analgesic, antimicrobial, antipyretic, anti-inflammatory, radioprotective, anti-ulcer, anticancer, gastroprotective, antidiarrheal, etc., to name a few. Many pharmaceutical herbal industries have...
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