Posted by admin on Apr 30, 2022 in |
To increase the efficacy of present anti-tumor agents, tumor-targeting can be proved as a successful approach for effective and safer drug delivery with less toxicity. According to researchers, for an effective tumor targeting module, disulfide linkage plays an important role in providing a medium for conjugating an anti-tumor drug with a carrier like vitamins and fatty acids. Disulfide bonds with unique chemical and biophysical properties can be used as cleavable linkers to deliver chemotherapeutic drugs. From the literature review, it has been observed that a disulfide bond acts as a self-immolating linker, which gets cleaved inside the body in the presence of intracellular glutathione; otherwise, it is stable in blood circulation. In this review, we discussed various strategies available in literature using disulfide as a linker in potent tumor targeting agents. Various successful conjugates are described here, which are currently under clinical...
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Posted by admin on Apr 30, 2022 in |
Moringa oleifera is an angiosperm plant that belongs to the family Moringaceae. It is also known as the Drumstick tree or Horseradish tree. Alkaloids, protein, quinine, saponins, flavonoids, tannin, steroids, glycosides, fixed oil and lipids are among the active phytoconstituents present. It is distributed throughout the world’s tropical and subtropical regions. Several studies show that various parts of the plant, such as seeds, flowers, bark, fruits, pods, gum and leaves, have antitumor, anti-inflammatory, wound healing, cholesterol-lowering, antioxidant, antidiabetic, antibacterial and antifungal, antimicrobial, antiulcer, antifibrotic, antifertility, antiurolithiatic, anticonvulsant, analgesic, local anesthetic, antiasthmatic and are used in the indigenous system of medicine to treat various diseases. This review aims to provide complete data, including morphology, cultivation and propagation, distribution, phytochemistry, traditional uses & Pharmacological...
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Posted by admin on Apr 30, 2022 in |
In previous studies, it has been shown that the activities of the glycolysis cycle enzyme are significantly altered with changes in kinetic attributes of hexokinase, phosphorfructokinase and lactate dehydrogenase. Moreover, the kinetic parameters of the terminal enzyme lactate dehydrogenase also changed significantly. In view of these observed changes, it was of interest to know if and how the flux of intermediates of the glycolytic pathway was also affected. With this objective, a simple, rapid and sensitive liquid chromatography-tandem mass spectrometry (LC-MS/MS) method has been developed for quantification of five important glycolysis intermediates of rate-limiting steps [viz. glucose-6-phosphate (G-6-P), fructose-6-phosphate (F-6-P), fructose-1,6-bis-phosphate (FBP), 3-phosphoglyceric acid (3PGA), and pyruvate in human erythrocytes. Liquid chromatography was performed using Supelco Ascentis Express RP amide (250 mm × 4.6 mm, 5µm) column with mobile phase, 10mM ammonium acetate in water and acetonitrile. The detection of metabolites was carried out by tandem mass spectrometry. In erythrocytes from Type 2 diabetic subjects, there was a significant increase in intracellular concentrations of G-6-P and 3-PGA, with a...
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Posted by admin on Apr 30, 2022 in |
Bangladesh is gifted with the world’s largest bay, rich in untapped resources that are undeniably beneficial to human wellbeing and the national economy. However, the people of Bangladesh have not yet been capable of using the vast marine resources of the Bay of Bengal due to a lack of adequate funds and technological limitations. On the other hand, countries like Japan, China and Indonesia utilize their resources from the sea and develop therapeutic agents and molecules to produce efficient lifesaving drugs. Nowadays, marine habitat is considered one of the most resourceful areas for natural product research. Marine organisms possess enormous biological, biochemical, and biosynthetic potential. Likewise, bioactive compounds from marine microorganisms opened the door for novel therapeutic compounds discovery and development, i.e., anti-cancer, antibiotics, antifungals, and antiparasitic. Marine endophytes from algae and sponges are almost endless sources of novel compounds with numerous potential therapeutic applications due to their enormous diversity and intrinsic ability to create natural products of medical and pharmaceutical significance. There are nearly 257 pharmaceutical companies in...
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Posted by admin on Apr 30, 2022 in |
Parkinson’s disease is a chronic progressive neuro-degenerative disease caused by selective degeneration of dopaminergic neurons in the dense part of the substantia nigra pars compacta. It is characterized by motor and non-motor symptoms, especially the gradual reduction of postural symptoms, instability, tremor and memory impairment, local neuron loss, which mainly occurs in the substantia nigra. The current study evaluated the effects of non-steroidal anti-inflammatory drugs on reserpine-induced Parkinsonism experimental model. Subcutaneous injection of reserpine (1 mg/kg) was given to all rats for 5 days to induce Parkinson’s like symptoms; syndopa (10 mg/kg) was used as standard, and aspirin (60 mg/kg), celecoxib (20 mg/kg) and Indomethacin (20 mg/kg) were given orally and after 60 min of reserpine were administered. Behavioural and neurochemical parameter assays were done for dopamine, acetylcholinesterase, lipid peroxidation and other antioxidant enzymes. Our results showed reserpine significantly induced locomotor deficits and oxidation in the brain in a period of 5 days. Celecoxib, aspirin and Indomethacin showed significant improvement in locomotor behaviour and showed neuroprotective activity by reducing...
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