Posted by admin on Apr 30, 2022 in |
Food adulteration is an enduring concern to date, and its detection and food authentication are some of the major approaches which can eradicate adulteration. This article reviews modern analytical techniques which are currently used for optimization and identification of adulterants. The Analytical techniques reviewed are distributed in three sections- Computer vision, Spectral and spectral Imaging techniques, and Electrical Techniques. Computer vision is a very advanced technique, allowing the analysis of several parameters with accurate and precise results. The hazardous effect of adulteration and future challenges and impacts are briefly discussed. The Previous decade is considered to be a massive success for food adulterant detection as it involved a chemometrics study. The use of chemometrics with analytical techniques is briefly discussed. Chemometrics is the science of extracting information from the chemical system by data-driven means. The inevitability of food in perspective to the current COVID-19 pandemic is very strong, and authenticated food is a prior...
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Posted by admin on Apr 30, 2022 in |
In the last decades, diabetes has become one of the most prevalent health concerns worldwide. Diabetes is a metabolic disease that causes hyperglycemia and is associated with altered insulin production (type 1 diabetes) or with insulin-resistance (type 2 diabetes). The present work aims to point out the relevance of glipizide as an alternative treatment for type 2 diabetes and discuss the different delivery systems developed for this drug. With this in mind, we performed a nonsystematic search in different databases like PubMed, Google Scholar, Science Direct and the FDA’s and some other web pages, using key words as search criterion. Because glipizide is a drug with a short elimination half-life, a dosage of two to three tablets per day is needed, depending on the therapeutic requirements of each patient. The as aforementioned has led different research groups to develop new delivery systems for this drug; among them are nanoparticles, nanosuspensions, microspheres, self-emulsifying systems, matrix tablets, osmotic tablets, and gastroretentive systems. The developed systems have been aimed at reducing the...
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Posted by admin on Apr 30, 2022 in |
Environmental factors influence plant growth, morphology, as well as nature and quantity of secondary metabolites. Modification of abiotic factors during plant growth can impact the production of bioactive phytoconstituents. A six-month field study was carried out to assess the effect of different abiotic stresses on bioactive compounds (flavonoids, phenols, quercetin), acetylcholine sterase (AChE) inhibition and antioxidant capacity of two selected Allium species i.e. Allium cepa L. (AC) & Allium sativum L. (AS; family Amaryllidaceae). AC and AS plants were grown for six months (from November 2018 to April 2019) on three different soil types (i.e. black, red, clay-loamy) and various stresses (salinity, water deprivation, flooding, fertilizer, metal, shade) were applied on the plants. At the end of the season, plants were collected, dried and plant yield was determined. Hydro alcoholic extracts of all samples were prepared. Extract yield, total flavonoids (TFC), total phenols (TPC), AChE inhibition, and antioxidant activity were determined in all the extracts. The results show the varied response of AC & AS plants to different soil...
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Posted by admin on Apr 30, 2022 in |
The study was designed to evaluate the anti-fatigue activity and biochemical effects of nootkatone in Balb-C mice. Thirty-six mice weighing 33-41g were randomly divided into six groups; 1) sedentary group, 2) sedentary group fed with 50 mg/kg nootkatone, 3) control group (exercise control), 4) exercise with 10mg/kg nootkatone group, 5) exercise with 25mg/kg nootkatone and 6) exercise with 50mg/kg nootkatone. Nootkatone was administered orally to mice from all groups. The anti-fatigue activity was assessed using a treadmill running test. Biochemical parameters were also evaluated. Nootkatone was found to increase run time on the treadmill and reverse the fatigue-induced reduction in liver/muscle glycogen, in addition to reducing lactate dehydrogenase (LDH) activity, blood urea nitrogen (BUN), and lactic acid. Moreover, nootkatone increases the activity of enzymes such as catalases, SOD and decreases lipid peroxidation. The data suggested that the nootkatone could extend the treadmill exercise duration in mice, as well as increase the tissue glycogen contents and decrease the malondialdehyde (MDA), lactic acid, BUN, CK and LDH levels. There was a...
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Posted by admin on Apr 30, 2022 in |
Three-dimensional printing (3DP) is an emerging technology that allows the fabrication of tailor-made drugs, devices, and organs that meet an individual patient’s requirement. Thus, it has enormous potential to bring about a significant transformation in the pharmaceutical and healthcare sector. 3DP involves the production of structures with desired design by deposition of printing material in a layer-by-layer fashion. It permits on-demand fabrication of structures with high productivity economically. Currently, it is employed in a wide range of healthcare services such as drug formulations, medical devices, anatomical models, tissue engineering and regenerative medicine, engineered tissue models, and dentistry. The primary objective of this review to describe various approaches in personalized medicine, progress in dosage forms and devices, 3DP techniques, use of polymers in 3DP and adaptation of 3DP in pharmaceutical industries. We further describe recent approaches in the fabrication of conventional drug formulations and novel drug delivery systems and compare the 3DP with 3D bioprinting. Lastly, we discuss the limitations, regulatory aspects, and future trends of 3DP technology in the...
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