Posted by admin on Apr 30, 2022 in |
Osteoarthritis (OA) commonly affects many joints in the human body, including the knee joints. The knee joint is made up of two parts – the patella-femoral (PF) and tibiofemoral (TF) compartment. Animal models for OA studies are well-established and serve as an important tool for understanding the impact of OA in humans. This study evaluates the anti-OA potential of a multi-herbal extract blend product – KEC (KARALLIEF EASY CLIMB) against monosodium iodoacetate induced OA in wistar rats in-vivo. Animals have equally divided into four groups, of which one group was the control, and other three groups were experimental groups. Biomarker estimation and histopathological evaluation were carried out. All values were expressed as mean ± SEM. The significant difference between the treatment and control group was estimated using one-way ANOVA with Dennett’s test. All results of the statistical analysis were summarized in separate tables. In any case, the values were considered statistically significant at P<0.05. This study found that treatment with KEC reduced the Monosodium Iodoacetate (MIA) induced osteoarthritis condition....
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Posted by admin on Apr 30, 2022 in |
Dementia, commonly Alzheimer’s disorder (AD), is a developing pandemic that presents profound challenges to healthcare systems, families, and societies in the course of the world. Alzheimer’s disorder, referred to as an innovative multifarious neurodegenerative disorder, is the essential motive for dementia in a late person’s life; brain developing older performs a pivotal feature in the pathogenesis and improvement of Alzheimer’s disease. Oxidative stress, a circumstance of unbalance between reactive oxygen species and antioxidants, provides a robust contribution to the excessive incidence of AD in old age subjects. The normal getting older technique is related to declines in positive cognitive abilities, such as processing speed and some factors of memory, language, visuospatial function, and executive function. Research in neurology has mounted decreases in the quantity of gray and white matter and upgrades in the feature of white matter that might also lead to cognitive changes determined with aging. It is necessary to think about these natural cognitive modifications because, first, they can have an effect on the daily functioning of...
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Posted by admin on Apr 30, 2022 in |
Current investigation was to evaluate antidiarrhoeal effect of Casuarina equisetifolia. Anti-diarrhoeal activity of methanol bark extract of Casuarina equisetifolia (CEME) studied on experimentally induced diarrhea in rats, castor oil-induced diarrhoea & enteropooling, meal transit time, and PGE2-induced entropooling. The CEME orally administered at doses 100, 200, and 400 mg/kg/atropine 0.1 mg/kg/ received control, respectively, were administered 30 min prior to the administration of castor oil. The CEME 100, 200 and 400 mg/kg/atropine 0.1 mg/kg/ received control to rats fed with as charcoal meal. Thirty minutes later, the intestinal distances moved by the charcoal were measured. The PGE2-induced enteropooling rats were treated with CEME orally at 100, 200, and 400 mg/kg/loperamide 2.5 mg/kg/1 ml of 5% v/v ethanol in normal saline, afterward PGE2 was administered orally to each rat, and intestine fluid volume was measured. The CEME 100, 200 and 400 mg/kg produced inhibition on the frequency of defecation by 33.89%, 42.66%, 59.64 %) and in diarrhoeic drops 35.83%, 43.06%, 49.72%. In PGE2-induced entropooling, intraluminal fluid accumulation reduced significantly. The...
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Posted by admin on Apr 30, 2022 in |
The leaves and roots extracts of Clerodendrum infortunatum was evaluated for its potential antioxidant and antibacterial properties. The correlation studies with phytochemicals were performed, which has not been widely reported yet. Clerodendrum infortunatum leaves and roots were screened for the presence of phytochemicals and were found positive for carbohydrates, saponins, alkaloids, tannins, phytosterols, coumarin glycoside, cardiac glycoside, phenols, flavonoids, and terpenoids. The phenols were quantified using the Folin-Ciocalteu method. The phenolics were found to be highest in ethyl acetate leaf (63.83 mg GAE/g) and ethyl acetate root extracts (87.21 mg GAE/g) at a concentration of 500 µl. Flavonoids were quantified by aluminium chloride colorimetric method, and it was found highest in ethyl acetate leaf extract (244.16 mg QE/g) and hexane root extracts (38.83 mg QE/g) at 500 µl. Aqueous leaf extracts (0.99 g) and hexane root extracts (0.99 g) had the highest total terpenoid content. The antioxidant activity was evaluated using DPPH assay. Aqueous leaves extract and ethyl acetate root extracts exhibited higher DPPH radical scavenging activity with an...
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Posted by admin on Apr 30, 2022 in |
Antihistamines appear to be the mainstay in allergic reaction treatment. Allergy is rooted in the primary rejection reaction of parasites in which histamine derived from mast cells generates an immediate aggressive environment, and eosinophils are recruited for killing. Antihistamines are medicinal products used to treat allergic rhinitis, conjunctivitis, urticaria, cold and flu, tachyphylaxis, motion sickness, and acute allergic reactions. A vast number of animals can be used for this activity, with rodents (inbred mice and rats) and guinea-pigs being the most common models, which are easy to maintain and relatively economical compared to other available models. Therefore, animal models used in asthma are greatly useful in antihistaminic studies because they promise new insights into human allergic symptoms. The available in-vivo and in-vitro models are used to investigate the mechanism of action of drugs with antihistaminic activity. This work aims to bring all the different in-vivo animal models and in-vitro techniques together for conducting antihistaminic activity...
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