Posted by admin on Feb 28, 2022 in |
Objective: Our work was to develop an ordispersible tablet of Dextromethorphan HBr with acceptable palatability to help patients of all age groups. Methods: The bitter taste of the drug was masked by entrapping the drug into Eudragit RL 100. The microspheres were prepared from solvent evaporation method. The effect of particle size, drug entrapment efficiency, % yield and % drug release of the microspheres was studied. Drug loading increased significantly with increasing the drug polymer ratio. Dextromethorphan was than further transformed into orodispersible tablet by using Hibuscus and Fenugreek as a superdisintegrants by using direct compression method. Physiochemical parameters and animal toxicity study of dried mucilage obtained from Hibiscus and Fenugreek were performed. In-vitro disintegration and in-vitro dissolution was carried out to observe the disintegration time and sustain release of drug. Results: In-vivo taste masked study was performed on albino rats. SEM, DSC and FTIR were done for identification, compatibility study and surface morphology. The or dispersible tablet made from sustained release microspheres showed release up to 10 h....
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Posted by admin on Feb 28, 2022 in |
The objective of current research is to assess the type of Adverse Drug Reactions (ADR) and associated risk factors, assess the prevalence, estimate the incidence of serious and fatal ADR and the severity of ADRs based on data collected from patients with ADRs caused by drug initially prescribed. Data of patients with acute diseases were collected and analyzed using SAS version 9.1. About 252 ADRs were identified among 183 patients. The majority of patients (70.49%) experienced one ADR reaction per patient. A higher risk of ADR was observed in the age group of 41-50 yrs (33.33%). The prevalence of ADR is predominant in adults (82.51%). ADR incidents were higher in gastrointestinal reactions (26.19%), with most of them identified by doctors or prescribers (44.41%). Suspected drug was withdrawn in 57.92% cases, specific and symptomatic treatment given to 45.23% followed by only symptiotic treatment for 30.95%. Definite improvement was predominant in challenged patients, whereas recurrence of symptoms was significantly observed among rechallenged patients with the respective suspected drug. According to the...
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Posted by admin on Feb 28, 2022 in |
The purpose of the present study was to optimize palbociclib-loaded solid lipid nanoparticles (SLNs) by evaluating the relationship between design factors and experimental data. A three-factor, three-level Box-Behnken design (BBD) was used for the optimization procedure, choosing the amount of tricapric, cremophor RH40 and soy lecithin, as independent variables. The chosen dependent variables were particle size, entrapment efficiency, and % cumulative drug released. The generated polynomial equations and response surface plots were used to relate the dependent and independent variables. The optimal nanoparticles were formulated with 08%tricapric, 09% cremophor RH40, and 6% soy lecithin. Three formulations were prepared according to these levels and found that the observed responses were close to the predicted values of the optimized formulation. The formulation PF13 was chosen for characterization as it displayed minimum particle size (103 nm), PI of 0.47, the zeta potential of -16 mV, maximum drug release of 98% in 12h. Fourier transform infrared spectroscopy (FT-IR) study indicated that the drug was entrapped in nanoparticles with no significant interaction between drug...
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Posted by admin on Feb 28, 2022 in |
Imidazole has a special role in heterocyclic chemistry, and its derivatives have piqued interest in recent years due to its diverse chemistry and pharmacology properties. Imidazole is a nitrogen-containing heterocyclic ring that is essential in biology and pharmaceuticals. As a result, imidazole compounds have piqued the attention of researchers for more than a decade. Thus imidazole compounds have been an interesting source for researchers for more than a century. Antibacterial, anticancer, anti-tubercular, anti-fungal, analgesic, and anti-HIV activities are among the biological activities of imidazole derivatives. This paper aims to look back on the biological activities of imidazole over the years. A large number of imidazole derivatives are available. The incorporation of the imidazole nucleus is an important synthetic Strategy in drug discovery. The high therapeutic properties of imidazole-related drugs have prompted medicinal chemists to develop a slew of new chemotherapeutic agents. In clinical medicine, imidazole medications have a broader application in treating a variety of conditions. Imidazole can be synthesized using a variety of...
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Posted by admin on Feb 28, 2022 in |
Ocular deliveries possess a challenging pharmaceutical approach due to poor absorption index through the corneal appendages and washing away of the drug through tears and lachrymal secretion. The ocular appendages lead to provide lesser bioavailability of conventional dosage forms; hence, frequent dosing is advised to get the optimum effect of the medicine. Therefore, in-situ gel offers a promising solution to provide a promising approach to achieve greater residence time and bioavailability of natamycin for ocular fungal infections. In the present study, the in-situ gel was prepared using Carbopol and HPMC, which upon introduction to the ocular cavity, were converted to gel. The prepared solution is kept at the pH of 5.0, which upon instilled into the ocular cavity to get converted to gel. The formulation is further assessed for parameters like viscosity, pH, gelling capacity, drug content, in-vitro drug release profile, sterility testing and antifungal activity of the same. The results of the in-vitro drug release have been proven for sustain release of the formulation as well as gelling...
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