Posted by admin on Jan 31, 2022 in |
Human beings always tried to protect their body from pathogenic microbes, whereas these pathogens always mimic and mutate themselves to infect humans. Nanotechnology is new and upgrading itself as well as enhancing its applicability in pharmaceuticals. Due to their nano-size structure, property drastically changes from their parent elements. Nanoparticles are used widely in biomedical sciences. Focusing on these perspectives, the present study investigates the impact of phyto-synthesized Zinc Oxide Nanoparticles (ZnO NPs) using Murraya paniculata leaf extracts. The characterization of synthesized ZnO NPs was 32 nm with a more optical stable showing peak value at 355 nm (UV-vis). Further, toxicological efficacy of ZnO NPs was checked against human pathogens viz., Salmonella typhimurium (causing typhoid), Staphylococcus aureus (causing tooth decay and rheumatic fever) and Escherichia coli (causing tooth decay in infants and dysentery). The anti-bacterial bioassay was done using a well diffusion method and compared with the standard drug streptomycin. The test pathogens were found more sensitive towards phyto- synthesized ZnO NPs with a Zone of Inhibition Diameter (ZID) value...
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Posted by admin on Jan 31, 2022 in |
Drugs have been controlled by the nasal route for remedial & therapeutic use since ancient times. Enthusiasm & importance for the basic impacts of drugs directed via the nasal route has developed to last decades. Intra-nasal drug organization provides an attractive substitute for achieving the important beneficial impacts of drugs virtually similar to the parenteral route, that may be improperly engineered on occasion or through the oral organization, that may contribute to inadequately low bioavailability of drugs. Along these lines, it is crucial to identify the potential & impediments of various nasal drug conveyance frameworks. In this way, the object of this paper is to study the different forms of pharmaceutical dosage that may be utilized in the vicinity or in a basic drug organization. It is obviously anticipated that this study would help to understand & advance expand appropriate intra-nasal strategies to meet specific restorative...
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Posted by admin on Jan 31, 2022 in |
The present research effort was undertaken to isolate phytoconstituents from pharmacologically active extracts of stem bark of Albizia stipulata based on in-vitro pharmacological screening and their subsequent characterization. Methods: Crude extracts of bark of Albizia stipulata were prepared using various solvents such as methanol, hydro alcohol, and water. These extracts were screened for in-vitro pharmacological activities like antioxidant, anti-inflammatory, and anti-diabetic activities. The active extract was subjected to column chromatography through a mixture of solvents to get fractions and eluted fractions were run in TLC using various mobile phases with different solvent ratios. The isolated compounds were subjected to IR, 1H NMR, 13CNMR and LC-MS spectral analysis for chemical characterization. Results: The methanol extract of bark of Albizia stipulata was potent compared to other extracts. This extract was subjected to column chromatography to get fractions, and eluted fractions were run in TLC. The fractions with similar Rf values to standard were united and crystallized. The spectral analysis confirmed that the isolated compounds were found to be β-Sitosteryl-3-O-β-D-glucoside and 3...
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Posted by admin on Jan 31, 2022 in |
In this study, Raman spectroscopy was used as an analytical quality control methodology to evaluate the paracetamol (PCT) quantity in a commercially available formulation in the pharmaceutical industry. The Raman Spectroscopy has been established for the validation and the quantification of PCT in a commercial product called Paracerol (Prc) Solution for I.V. Infusion containing 10.0 mg.mL-1 PCT. The validation of the proposed method was performed by evaluating the specificity, linearity range, accuracy, precision, detection limit, quantification limit, and robustness parameters. The acceptable results for all parameters showed that the proposed method is valid. The Raman spectroscopic method was also compared with the HPLC method in terms of PCT determination and statistical tests such as t and F tests and the obtained results indicated that there is no any difference in the averages and precision results between the proposed Raman spectroscopy and HPLC methods. It has been reported that Raman spectroscopy can be applied in the pharmaceutical industry for the quality control analysis of the commercial formulation of...
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Posted by admin on Jan 31, 2022 in |
Perilla frutescens (Linn.) is an annual herbal medicinal, aromatic, vitamins-rich food and ornamental plant that belongs to the mint family, Lamiaceae. It is distributed throughout India, extending to China, Japan, Korea, Taiwan, Vietnam, and other Asian countries. Perilla frutescens seeds, leaves and stems contain fixed oil which is useful edible oil. It is an alternative source of polyunsaturated fatty acids (linolenic acid (54%-64%), i.e., omega-3-fatty acids), phenolic compounds (rosmarinic acids, luteolin, chrysoleriol, quercetin, catechin, protocatechuic acid, and apigenin), natural antioxidants, vitamins and minerals. Recent advances prove that compounds purified from Perilla frutescens have been proven to be biologically active against several major diseases to treat depression-related diseases, anxiety, asthma, chest stuffiness, vomiting, coughs, colds, flu, phlegm, tumors, allergies, intoxication, fever, headache, stuffy nose, constipation, abdominal pain, and indigestion. It also acts as an analgesic, anti-abortive agent, sedative such as an antioxidant, antimicrobial, anti-allergic, antidepressant, anti-inflammatory, anticancer and neuroprotective activities. This present review deals with the update of biological activities of isolated bioactive chemical constituents of Perilla frutescens and explores...
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