Posted by admin on Feb 28, 2023 in |
Coumarin and its derivatives are widely used as scaffolds in synthesizing new heterocyclic systems. Numerous approaches especially involving nano-particle catalysts, have been developed to get new bioactive coumarin derivatives endowed with pharmacological and biological activities. The present work describes the reactivity and the new strategies for the synthesis of coumarin and its derivatives reported in the literature and their biological properties. Coumarins possess a number of biological activities like Anticoagulant, Antimicrobial, Anti-inflammatory, Analgesic, Antioxidant, Anticancer, Antiviral, Anti-malarial etc. Coumarin belongs to a group as benzopyrones, which consists of a benzene ring joined to a pyrone nucleus 12. Coumarins (2H-1-benzopyran-2-ones) are important oxygen-containing fused heterocycles used in drugs and dyes. A number of coumarin derivatives have been reported to have diverse biological activities like fungicidal1-4, molluscicidal 2, antihelminthic 5, 6 and CNS 7 stimulants. Mannich Bases of some heterocyclic compounds are also reported Bioactive 8, 9. In view of this Mannich bases of 7 – hydroxyl – 4 – methyl coumrin and 4, 6, 7– trimethyl coumaryl incorporating various DL–amino...
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Posted by admin on Feb 28, 2023 in |
Phytomedicines from herbal plants are widely used as a home remedy in ancient times to maintain the normal health of human beings. As per World Health Organization (WHO) estimation, nearly 75-80% of the population in the world utilizes medicinal plants for their primary health care. Duranta erecta itself has antioxidant and anti-microbial activities and has been used in Africa and Asia to treat a wide range of diseases. Evaluation of the study is based on the phytochemical profile, anti-microbial and antioxidant activities of D. erecta to ascertain its health benefits in traditional medicine. Plant parts with antimalarial, anti-bacterial, antioxidant, anthelminthic, antifungal, antiparasitic, insecticidal, and cytotoxic activity have been reported to include leaves, fruit, stems, and flowers. Fruit, flowers, leaves, and stems were screened for the presence of phytochemicals such as iridoid glycoside, alkaloids, flavonoids, saponins, terpenes, tannins and sterols, C-alkylated flavonoids beta-sitosterol, naringenin, triterpenes saponins, steroidal glycosides. Plant extracts of D. erecta leaves that have antioxidant activities show potential effects in many conditions initiated by oxidative stress. This review reveals...
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Posted by admin on Feb 28, 2023 in |
Background: Shivering is one of the most troublesome and distressing experiences for the patient encountered intraoperatively following spinal anaesthesia. Tramadol is very commonly used in clinical practice for post-spinal shivering but has side effects. The study aimed to compare the efficacy of dexmedetomidine with that of tramadol for prophylactic use in post-spinal anaesthesia shivering. Methods: A prospective, randomised controlled study was conducted on 210patients (American Society of Anaesthesiologists class I and II) of either gender, aged between 18 and 65, scheduled for elective lower abdominal and lower limb surgeriesunder spinal anaesthesia. The patients were randomized into three groups of 70 patients each. Group D received dexmedetomidine (0.5 µg/kg in 100 ml NS), Group T received tramadol (0.5 mg/kg in 100 ml NS) and Group C received 100 ml NS. All the drugs were given as an infusion over 10 min.The incidence and severity of shivering were recorded at 0min, 5min, 10min, 15 min and then every 15min till the end of surgery. The data was analyzed using IBMSPSS20 for...
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Posted by admin on Jan 31, 2023 in |
Semecarpus anacardium Linn. (Family Anacardiaceae), generally known ‘Ballataka’ or’ Bhilwa’, is a factory well-known for its medicinal value in ayurvedic and siddha system of the drug; it’s also used for non-medicinal purpose like marking of cloth, hair color, etc. since ancient time. Phytochemical analyses of Semecarpus anacardium nut shows that, its nut contains a variety of biologically active composites similar as biflavonoids, phenolic composites, bhilawanols, minerals, vitamins, and amino acids, which shows colorful medicinal parcels. The oleic acid content present in the kernel indicated that it could be used as a good source of salad oil. Traditional healers and croakers use Semecarpus anacardium in their clinical practice. Several trials have proved its anti-atherogenic, anti-inflammatory, antioxidant, antimicrobial, anti-reproductive, CNS stimulant, hypoglycemic, anticarcinogenic and hair growth protagonist conditioning. An exhaustive literature survey was performed on Semecarpus anacardium Linn by using various scientific databases to validate the ethnomedical properties of the plants. The present review of literature has focused on ethnomedicinal, nutritional value, phytochemical components, and pharmacological properties of Semecarpus anacardium...
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Posted by admin on Jan 31, 2023 in |
Persistent Mycobacterium tuberculosis (Mtb) attributable to resistant strains has increased the burden leading to poor quality of life to the patients. Drugs of herbal origin have been identified as potential sources of new anti-tubercular agents for the treatment of this disease and emerging resistant strains of the bacterium. In this research, therefore, five herbs/plants that have been indicated in the treatment of Mycobacterium tuberculosis in the traditional/folklore medicine were evaluated for their potential use in the treatment of Mycobacterium tuberculosis infection. Garcinia kola, Picralina nitida, Mitracarpus villosus, Vernonia amygdalina and Securidaca longipedunculata were assessed for their anti-tubercular activity using standard methods. G. kola and V. amygdalina having better activity were assessed for their synergistic activity. Doses displaying in-vivo activity were established. The activity of the synergistic mix with Rifampicin was evaluated in a resistant Mtb strain. Two plants; G. kola (MIC of 125 mg/ml) and V. amygdalina (MIC of 250 mg/ml) performed better than others. The synergistic ratios of V. amygdalina, G. kola of 1:1, 2:1, 4:1 and 8:1...
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