Posted by admin on Jan 31, 2023 in |
The present investigation was carried out to analyze the bioactive metabolites of red seaweed Champia compressa collected from Mandapam, Ramanathapuram district, Tamil Nadu, India. The collected sample was evaluated for qualitative and quantitative phytochemical screening analysis using five different solvents methods. The preliminary qualitative analysis of Champia compressa solvent extracts revealed the presence of flavonoids, tannins, steroids, cardiac glycosides, terpenoids, coumarins, alkaloids, saponins, and phenols. Further quantitative phytochemical analysis was performed using standard procedures that revealed the presence of the highest phenol content (506.67 mg GAE/g) found in aqueous extract and the lowest in chloroform extract (8.33 mg GAE/g). Similarly, alkaloid content (34.09 mg AE/g) was highest in ethyl acetate extract and lowest (15 mg AE/g) in aqueous extract. The highest steroid content (85.88 mg BSE/g) was observed in hexane extract, whereas the lowest (3.69 mg BSE/g) in chloroform extract, however terpenoid (30.25 mg LE/g) was higher in methanolic extract, and the least (3.38 mg LE/g) found in aqueous extract respectively. The FTIR characterization represents the functional groups of...
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Posted by admin on Jan 31, 2023 in |
Citrus sinensis are treasuries to deliver novel drugs and a significant aromatic medicinal plant reported to possess a broad spectrum of medicinal uses. The compounds present in these plants can deliver the potential therapeutic drug. A free web tool, SWISS ADME predictor, was used to evaluate the pharmacokinetics, drug-likeness, and medicinal chemistry friendliness of phytoconstituents under investigation. The in-silico study has been deployed to screen the phytochemical components D-limonene, α-pinene, and β-pinene in Citrus sinensis. Against the protein target of RNA-dependent RNA-polymerase and Spike receptor binding domain with the aid of AutoDockVina software. All calculations for protein-fixed ligand-flexible docking were done using the Lamarckian Genetic Algorithm (LGA) method and analyzed using BIOVIA Discovery Studio 2016.13. The Phytoconstituents also showed good hydrophilic-lipophilic balance, good bioavailability, and decent GI absorption. The results obtained after docking showed a good binding affinity and implicated the active phytoconstituents for drug discovery and...
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Posted by admin on Jan 31, 2023 in |
Nanoemulsions, also mentioned as submicron emulsions, ultrafine emulsions and miniemulsions, are submicron-sized colloidal particulate systems considered as thermodynamically and kinetically stable isotropic dispersions; they contain two liquids like water and oil (immiscible), stabilized by an interfacial film consisting of a suitable surfactant and co-surfactant to form a single phase. In this research, lawsone nanoemulsion was developed by using Neem oil, tween 80 and ethanol. The formulation optimization was done by designing a ternary phase diagram followed by water dilution method. We developed 6 formulations (F1-F6) with different concentrations of oil and surfactant but drug concentrations are the same in all developed formulations. Developed formulations are evaluated for different parameters like pH, solubility, drug content, viscosity, transparency, size of globules and stability study, etc., and found to be appropriate in all tests. Since, oil/water Nanoemulsion had greater density than water/oil systems, the stiffness values increased significantly whenever the water content increases or when the system switched to oil/water type. Antimicrobial screening of the drugs and formulations were also screened against...
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Posted by admin on Jan 18, 2023 in |
Phytosomes is vesicular drug delivery system in which phytoconstituents of herb extract surround and are bound by lipid. Hexadecanoic acid is the phytoconstituents of Nigella sativa oil. Hexadecanoic acid is hydrophobic and possesses less solubility and permeability. The study aims to formulate, optimize, and evaluation of hexadecanoic acid phytosomal gel for anti-fungal activity hexadecanoic acid loaded phytosomes were prepared using Thin film hydration method and were optimized using factorial design (32) using Design-expert® software (Version 7.0.0, Stat-Ease Inc., Minneapolis, USA) different formulations were prepared. Two different independent variables were used, which include: Amount of Soya lecithin (X1), amount of cholesterol (X2) and the responses are particles size determination (Y1), and entrapment efficiency (Y2). The optimized formulation of hexadecanoic acid phytosomes was incorporated into a Carbapol 934 gel base and 1.5% of hexadecanoic acid phytosomal gel was prepared which was evaluated for drug content, pH, Spreadability, viscosity and in-vitro drug release. The prepared hexadecanoic acid phytosomes had a maximize EE% was found to be (72.23%), particle size was found to...
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Posted by admin on Dec 31, 2022 in |
Nutraceutical is a word obtained from Nutrition and Pharmaceuticals. Nutrients are a feed constituent that helps to support the life of human beings or animals. Pharmaceutical components are non-toxic food constituents, including prevention and treatment of disease. They commonly inhabit the disorders associated with oxidative stress, for instance, cardiovascular disease, Diabetes, and Hypertension. Nutraceuticals possess substantial importance because of their expected safety and possible nutritional and therapeutic effects. Hypertension is the most frequent risk factor for cardiovascular disease involving coronary heart disease and stroke. There is a crucial role in utilizing single and integral nutraceutical supplements, vitamins, antioxidants, and minerals in the treatment of hypertension. These food supplements rein huge demand because they are less toxic and have long life treatment with dietary food. We have done a face-to-face survey on 33 medical stores. The survey results found that the most demanding nutraceutical is Mactotal, and the least demanding nutraceuticals are Beryl tone and Allvell-Z graph seed extract. The survey study also shows a list of Nutraceuticals that are...
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