Posted by admin on Oct 31, 2023 in |
Currently, COVID-19 pandemic is a major zoonotic disease that has killed millions of people all over the world. Similarly, Nipah virus (NiV), causes severe acute respiratory syndrome (SARS) along with febrile encephalitis. NiV belongs to the class of paramyxovirus of the genus Henipavirus is a deadly virus that has caused several outbreaks in recent years. Despite the fact that NiV causes a small number of infections, the severity of the disease results in a higher death rate unlike COVID-19 infection. Many research studies termed bats as a natural host for NiV. Recently two NiV strains were identified i.e. NiV-MY (Malaysian strain) and NiV-BD (Bangladesh strain), is the major cause of epidemic in various geographical areas. Various techniques like ELISA, immunohistochemistry and polymerase chain based reaction have been developed for diagnostic purposes. Currently, there is no approved treatment or vaccine available for either people or animals, and treatment is limited to supportive care. In context with current COVID-19 pandemic, health infrastructure in many countries will be incompetent to manage such...
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Posted by admin on Sep 30, 2023 in |
The Box jelly fish Chiropsoides buitendijki (Horst R, 1907) were collected during low tides from Edwan village, of West Coast of Mumbai. Identification was done at the Central Marine Fisheries Research Institute (CMFRI), Mumbai. Crude extract of Chiropsoides buitendijki (Horst R, 1907) was obtained following the 80% methanol and 1%acetic acid, absolute methanol and n-butanol (1:1), and n-butanol. The antibacterial activity was carried out on bacteria E. coli, K. pneumonia, S. aureus, S. flexneri, V. Cholerae, C. sporogenes, S. enterica, E. faecalis, and fungal strain Candida albicans and Aspergillus niger whereas the antimycobacterial study was carried out on Mycobacterium tuberculosis (MTB) strain, H37 Rv: ATCC No- 27294. From the above study it is confirms that, the crude extract of Chiropsoides buitendijki have antibacterial and anti- tuberculosis...
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Posted by admin on Sep 30, 2023 in |
Antimicrobial proteins and peptides are also known as Host defense system. Recently, research in the food industry and therapeutic fields has seen a considerable expansion in the use of antimicrobial proteins. It has a wide spectrum of antibacterial and immunomodulatory properties against infectious bacteria, viruses, fungus, etc., obtained from microbes, plants, animals, and even humans. Antimicrobial peptides can potentially improve the specificity and efficacy of antibiotics by being a promising alternative because microorganisms can’t metabolize them. Regulation, post-transduction modification, ribosome synthesis, etc. are the essential components of the AMP (Antimicrobial protein and peptide) biosynthesis process. Today, AMPs can be developed synthetically based on their activity, source, structure, and species of amino acids. They have the unique ability to rupture the cell wall, which results in cell death. As a novel approach, scientists have determined a few strategies to administer AMPs by formulating with chitosan nanoparticles, gold and silver nanoparticles, and peptide-assembly by producing microgels, mesoporous materials, and other substances that can be applied in the fields of skin disease,...
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Posted by admin on Sep 30, 2023 in |
This study investigates the presence of bioactive compounds present in the tubers of Curcuma zedoaria using GC-MS analysis. Different compounds, including alkaloids, tannins, flavonoids, and proteins, were identified using the preliminary phytochemical screening for aqueous, ethanol and methanol extracts. The present study reports the antimicrobial activity analysis using aqueous, ethanol and methanol extracts. The results show that the ethanol and methanol extracts showed relatively enhanced results. The extracts were subjected to GC-MS analysis, and antibacterial properties for the extracts were analyzed. Bioactive compounds such as 1,2 cyclopentanedione, 2(5H)-furanone, hexadecanoic acid, succinic acid, oleic acid, pyrrolidine etc., were identified through GC-MS. These compounds exhibited various therapeutic functions such as anticancer, anti-inflammatory, and anti-microbial activity. The antibacterial assay showed a considerable zone of inhibition for the ethanolic extracts in the case of K. pneumonia and B. subtilis. Hence, these crude extracts can be used as a better and alternative source, which can be used in herbal medicines. The study concluded that C. zedoaria tuber contains various bioactive compounds. Therefore, this tuber...
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Posted by admin on Sep 30, 2023 in |
Neurological problems should be considered a major public health issue. Around 40%–70% of people exposed to HIV suffer neurological problems such as Amyotrophic lateral sclerosis (ALS), Parkinson’s disease (PD), and other comparable conditions. Various neurological diseases including ALS, Alzheimer’s, and Parkinson’s disease are caused by amyloid-beta accumulation in extracellular regions of the brain. The Substantia nigra’s dopaminergic neurons have been damaged in a widespread and gradual manner. The life span of HIV-infected patients has risen during this period of antiretroviral medication, resulting in increased neurocognitive impairment in around 33% of HIV entities, mainly adults. The testimony of the A inscriptions in the CNS is the most popular sight among elderly HIV patients. ART is separated from harmful duplication, but the harmful neuronal protein (Tat) is still produced, following in facilitated A phases. Furthermore, Cocaine-like drug (COC) use has been linked to HIV-related neurocognitive issues and A excretion. Withaferin A is emitted by inducing the targeting Tat and COC, we suggest Withaferin A (WA), a contemporary bifunctional fragment that acts...
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