Posted by admin on Sep 30, 2023 in |
Background: Post-marketing surveillance via spontaneous Adverse drug reaction (ADR) monitoring and reporting method is in place, even though it is considered as one of the key challenge for under-reporting and establishing the quality of patient safety in the healthcare system. Objective: This study is intended to know the clinician’s opinion (mindset) on the implementation of PvPI-Helpline (Helpline Number) and concise ADR form in In-patient case sheets at a tertiary care teaching hospital, Telangana India as they play a vital role for improving the reporting system of ADRs. Materials and Methods: A Cross-sectional Surveillance based study was carried out in Osmania medical college and affiliated hospitals, for 2-months duration among 160 Clinicians. The questionnaire consists of 4 questions and the participants were informed to provide their feedback. Data was collected and analyzed using SPSS version 25 software. Results: Only150 clinicians responded. 98.6% of Clinicians agreed to implement PvPI-Helpline (Toll-Free) number for quick reporting of ADRs.93.3% disagreed with creating a WhatsApp group for reporting ADRs as they taught it was not a secure platform to...
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Posted by admin on Sep 30, 2023 in |
This investigation evaluates the oral toxicity of Phaseolus vulgaris immature pods decoction a the biochemical, hematological, and cardiac profile of Wistar rats. Methods: The Economic Cooperation and Development Organization (OECD) guidelines 423 and 407 were applied. A 2000 mg/kg dose of PAD was administered to six female mice. Mortality, body weight, clinical signs of toxicity, food and water intake were recorded for 14 days. In the subacute oral toxicity test, daily doses of 100, 500, and 1000 mg/kg of PAD were administered to groups of five rats of both sexes for 28 days. Mortalities, clinical signs of toxicity, weight growth, water, and food intake were recorded throughout the period. Results: PAD did not cause mortality or significant clinical signs of toxicity at 2000 mg/kg bw. The LD50 of this extract was estimated to be 5000 mg/kg bw. All animals survived daily administration of 100, 500, and 1000 mg/kg of PAD decoction. The weight gain was comparable to that of the control groups in male and female-treated rats. Furthermore, no...
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Posted by admin on Sep 30, 2023 in |
A study was performed to develop a simple HPLC method for estimating sertraline Hydrochloride in unit dose. The method was created by evaluating the drug sertraline hydrochloride’s solubility in phosphate buffer, pH 4.0, at 254 nm. The chromatographic separation was accomplished on Prominence I LC 2030 C (Shimadzu Corporation, Japan). A 10 µl sample volume and a C18 column (250 x 4.6 mm (5 µm) were employed. The created and improved procedure produced the desired results. A 0.9998 linearity value was discovered. Buffer (Monobasic Potassium Phosphate of Buffer pH 4.0): Acetonitrile: and Methanol (50:25:25) were combined in a mobile phase designed for the technique at a 2.0 ml/min flow rate. Sertraline Hydrochloride was simultaneously identified at 254 nm with a retention time of 10.4±0.2 min. The percentage of the medicine was calculated using the specification limits after a quantitative assay of the commercial formulation. According to ICH guideline Q2R1, validation was completed successfully. The suggested approach can be used for a BE study to assess its applicability further and...
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Posted by admin on Sep 30, 2023 in |
Nanotechnology has found its way into most science fields at a tiny scale. Particle of this size and molecules were found to work differently and got diverse applications. Novel drug delivery system leads to the development of Nanocarriers, including Nanoparticles, Nanospheres, Nano capsules, Nano emulsion, liposomes, and Niosomes. The major area for research is to design Nanoparticles that can efficiently manage particle size, surface properties, and drug release. For this to get characterizations of Nanoparticles, it is critical to control their desired in-vitro and in-vivo behavior. Nanoparticles are characterized by their size, surface morphology, and surface charge, using highly advanced microscopic techniques. Colloidal stability is ascertained through zeta potential. Nanoparticles are also characterized by polymer and drug interaction. In-vivo characterization for binding and internalization of targeted carriers to the specific cell and bio distribution study of targeted Nanoparticles could also be confirmed using confocal microscopy. This review covers all the aspects related to the characterization of the pharmaceutical...
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Posted by admin on Sep 30, 2023 in |
In this advanced technological world, the computer has become an indispensable piece of equipment in both office and home. Visual and ocular problems have recently been reported as the most frequently occurring health problem among computer users. Prolonged exposure to radiofrequency radiation affects eyesight and indirectly affects the whole body function. The herbal supplements that improve eye vision are more effective for all age groups and those involved in jobs that cause strain over the eye. Computer Vision Syndrome (CVS) is caused by extensive computer use that reduces eye blinking rate. CVS comprises symptoms like dry eye disease, strain, redness, and irritation. Sight promoters relieve strain, and energize eyes to keep it healthy. They protect and enhance the vision. In Siddha, many herbs and day-to-day disciplines are advised to maintain good vision. This review article discusses the herbs and other disciplines to be followed that will be helpful in the prevention and management of...
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