Posted by admin on Apr 30, 2023 in |
Favipiravir is, an antiviral agent, used to treat diseases caused by RNA viruses like Ebola virus, SARS-CoV-2, Influenza virus, Polio measles etc. The prodrug Favipiravir enters the infected cells through endocytosis and undergo metabolism to become an active drug. An active form of Favipiravir selectively targets the catalytic domain of RNA-dependent RNA polymerase and then interrupts the nucleotide incorporation process during viral RNA replication. This dysregulation of viral RNA replication results in mutations where the replacement of guanine by adenine and cytosine by thymine occurs. This ultimately induces destructive mutagenesis in RNA viruses. Currently, Favipiravir is available in tablet and intravenous dosage forms. The following analytical methods have been carried over for Favipiravir: UV, HPLC, LC-MS/MS, Spectrofluorometric method, and HPTLC-densitometric techniques are reported as per literature. The present paper illustrates the review of analytical methods which involve the estimation of Favipiravir in bulk or dosage form. The review also describes the scope and limitations of many published analytical methods for the analysis of Favipiravir. This detailed review article will...
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Posted by admin on Apr 30, 2023 in |
The present study aims to develop and characterize colon-targeted mesalamine microsponges for treating inflammatory bowel disease, requiring long-term therapy. Mesalamine microsponges were prepared with different ratios of eudragit S100, by quasi-emulsion solvent diffusion method and evaluated. The drug release from in-vitro dissolution for all the prepared microsponges was extended to 12 hrs and above, and release kinetics followed a biphasic pattern with Higuchi non-fiction diffusion predominantly. SEM images clearly showed drug entrapment effectively in the microsponges based on the % yield, entrapment efficiency, drug content, and complete drug release (12-15 hrs). Microsponges prepared with a drug-to-polymer ratio of 5:1 (ES5) were considered suitable formulations. Microsponges were equivalent to a dose of 500 mg and were compressed into core tablets by direct compression. All the tableting parameters complied with the official compendia test for tablets as per IP. As the compression of the microsponges did not alter the release, tablets were further subjected to compression coating with cellulose acetate phthalate for colon targeting. From in vitro dissolution studies, drug release...
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Posted by admin on Apr 30, 2023 in |
The rapid rate of mutation of the RNA genome of the Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) is responsible for the emergence of viral variants, leading to the enhanced survivability of the virus. Hence, searching for new drugs that can restrict new viral infections by interacting with wild-type and mutated viral proteins is important. However, new drug development’s economic and time-constraining nature makes ‘drug repurposing’ a more viable solution to address the problem. In this work, we conducted a computational study to screen 23 Non-Steroidal Anti-Inflammatory Drugs (NSAID) interactions with 5 major viral proteins of SARS-CoV-2 that are mainly involved in host infection. Our in-silico results establish a database that shows that different NSAID ligands interact with the different viral proteins with good binding affinities. Stabilizing point mutations were introduced within the conserved amino acids involved in ligand-protein interactions. Redocking the NSAID ligands with these mutated viral proteins showed that the NSAID ligands could bind with the mutated and wild-type viral proteins with comparable binding affinities. We conclude that...
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Posted by admin on Apr 30, 2023 in |
A wound is described as a break in a tissue’s cellular and anatomic continuity. A wound is a cellular, anatomical, and functional disturbance of living tissue induced by physical, chemical, electrical, or microbiological threats to the tissue. Wound healing is a multi-step process involving injured tissue regeneration or restoration. The typical wound-healing response is a coordinated series of processes that starts with an injury. Wound healing is a series of interconnected cellular and biochemical activities that result in restoring structural and functional integrity and re-establishing strength in wounded tissues. This study includes a review of plants with wound-healing activities found via ethnobotanical and folklore medicinal surveys. This article discusses the wound-healing capabilities of plants, as well as their botanical names, common names, families, parts utilized, and references, all of which might assist researchers to design novel wound-healing formulations for human...
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Posted by admin on Apr 30, 2023 in |
Withania coagulans, commonly known as Rishyagandha in Sanskrit and Paneer phool in Hindi, is a plant in the Solanaceae or nightshade family, native to Afghanistan, Pakistan and the Indian subcontinent. Within the genus Withania, W. somnifera and W. coagulans are economically significant and are cultivated in several regions for their use in Ayurveda. Roots of W. somnifera have been known since ancient times for their use as Rasayana for the overall wellbeing of humanity. Withania coagulans fruit, though not as popular, has earned its medicinal importance because of its recently claimed use in diabetes. The antidiabetic activity of the plant is attributed to several reported phytoconstituents ranging from steroidal lactones like withanolides and withaferins to coagulonides and withacoagulins etc. The plant has also been reported to possess a wide range of pharmacological activities like antidiabetic, anticancer, immunomodulatory, hepatoprotective, neuroprotective, anti-inflammatory and many more. Though from the well-appreciated Withania family, the plant Withania coagulans, could attract less attention from the researchers. Hence, this review article aims to highlight the recent findings on the chemical and pharmacological potential of Withania coagulans, aiming to...
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