Posted by admin on Apr 30, 2023 in |
Simple, very Sensitive, rapid, and accurate novel spectro-photometric methods were developed to estimate Lenvatinib in Pharmaceutical dosage form using zero- and first-order derivative spectrophotometry. The solutions of Lenvatinib standard and sample were prepared using analytical grade methanol. The spectrophotometric estimation of lenvatinib was carried out at 240 nm in the zero-order method and 253 nm in the first-order derivative method. Developed methods were validated with respect to linearity, precision, accuracy, limit of detection and quantitation in accordance with International Council for Harmonisation (ICH) guidelines. Linearity was observed in the concentration range of 1-5 µg/mL for zero- and first-order derivative methods. LOD and LOQ of Lenvatinib were found to be 0.017 µg/mL and 0.052 µg/mL for zero-order and 0.165 µg/mL and 0.500 µg/mL for first-order derivative spectrophotometric methods, respectively. The %RSD values for inter-day and intra-day precision study were <2.0%. The method was linear, accurate and precise with recoveries in the range of 98 – 102 %, and minimum values of %RSD indicate the method’s accuracy. Developed spectrophotometric methods were...
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Posted by admin on Apr 30, 2023 in |
Oral controlled release and site-specific drug delivery systems have gained interest in the pharmaceutical industry to improve the treatment of certain critical medications. To overcome physiological barriers, such as short stomach resident lengths and variable gastric emptying periods, the idea of a novel drug delivery mechanism evolved. To improve the bioavailability of drugs with narrow therapeutic windows, delay the onset of drug elimination from the body, and increase patient compliance, one of these novel approaches is the gastroretentive drug delivery system (GRDDS), which is implanted in the upper part of the gastrointestinal tract. This investigation discusses the GRDDS, factors associated with the GRDDS, the advantages and disadvantages of the GRDDS, alternative approaches to the GRDDS, and different polymers used for gastroprotection. A great deal of work is being put into developing several GRDDS types at the moment. Because of this, pharmacotherapies of all types stand to benefit from their growing prominence...
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Posted by admin on Apr 30, 2023 in |
Allopathic drugs are generally prescribed for Diabetes Mellitus (Type-II) patients. As the disease is chronic in nature, it necessitates the use of alternative medicine(s) either to supplement the existing allopathic therapy and/or to reduce the associated side effects with their chronic use. The use of herbal drugs is presumed to be safe option due to fewer side effects. However, evaluation of safety of their combination by scientific validation is very essential. Here we evaluated the safety of routinely used second generation drug Gliclazide along with Berberine (herbal drug). The study was conducted in two dissimilar species, rats, and rabbits. In rats and rabbits, the dose of 100 mg/kg of Berberine and 1 mg/Kg Gliclazide dosed separately produced~30% reduction in blood glucose. When both Berberine and Gliclazide were given in combination at similar doses, reduction in blood glucose was found to be ~60%, suggesting significant pharmacodynamic interaction between them. Also, in the rabbit study, Gliclazide pharmacokinetic parameters were studied. We observed significant changes in the pharmacokinetic parameters of Gliclazide (AUC,...
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Posted by admin on Apr 30, 2023 in |
Physical interactions between proteins are cardinal to biological processes. To restore their function, proteins must interact with one another. Hub proteins are densely interconnected proteins with a wide range of biological significance and are also to blame for several illnesses, including cancer, autoimmune disorders, and neurodegenerative diseases. The most prevalent of these is Parkinson’s disease. SNCA, alpha synucelin is a hub protein that is the main cause of this disease; along with this DJ 1 and Parkin also responsible for Parkinson’s disease. Through this study, we performed a molecular-level comparative analysis on hub-proteins of Parkinson’s disease with selected synthetic drugs using the in-silico approach. The binding energy and complex energy identified the better efficacy of the drug. The Lipinski rule of filtering and the ADMET pharmacological parameters were satisfied by seven out of the twelve medicines. Levodopa, among these medications, had superior effectiveness with 4RKW and 5C32 in both approaches. Better Lib Dock scores, binding energies, and complex energies with 4RKW were displayed by safinamide. The molecular dynamic modelling...
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Posted by admin on Apr 30, 2023 in |
With the popularity of biologics, treatment for several inflammatory diseases has improved significantly. Biologics are a group of drugs obtained from biological sources that primarily function by suppressing part of the host immune system. However, this process comes at a cost, as it has been reported that the use of biologics carry a major risk in the form of tuberculosis. To verify this claim, a meta-analysis of biologic therapy vs. placebo therapy was designed to test biologics of different inflammatory diseases and check for tuberculosis as their side effect. This test included psoriasis, rheumatoid arthritis, psoriatic arthritis, ankylosing spondylitis, Crohn’s disease, and ulcerative colitis. It was found that biologics used in treating these diseases were mainly responsible for the spread of tuberculosis as a side effect. By mining different databases for literature mentioning biologics that qualify clinical trials and checking for heterogeneity for each study, primary measures were tested for each disease to determine the spread of tuberculosis when treated with these compounds. Meta-analyses were conducted for the study...
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