Posted by admin on Apr 30, 2023 in |
Diabetes mellitus is a complex disorder where oxidative stress plays a crucial role in the development and progression of the disease. In the present work, the rat model evaluated pancreas and liver tissue damage caused by a high-fat diet and diabetic complications. Male Wistar rats were administered with HFD- corn oil orally for 28 days followed by streptozotocin (STZ) injection to induce diabetes on 29th day. The drug treatment groups were given low dose (250mg/kg) and high dose (500mg/kg) of hydroalcoholic extract of Achyranthes aspera (HEAA), and its therapeutic efficacy in HFD + diabetes model was compared with the standard drug metformin. Various antioxidant parameters were measured, including MDA, protein, GSH levels, SOD, and CAT activities. The histology of pancreas tissues was also analyzed using Haematoxylin, Eosin, and Masson-trichrome staining. The expression of insulin protein in the pancreas was studied by immunohistochemical technique. The effect of drugs on GLUT-2 and PPAR-α gene expression showed considerable improvement in the liver tissues of different groups. From the results, it can be...
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Posted by admin on Apr 30, 2023 in |
Background: Our study aims to document the use of ethnomedicinal plants reported by herbalists in treating ailments that are becoming more prevalent. Using an ethnobotanical approach and in-silico studies, will advise further prevalence and give precedence to future pharmacological studies. Methods: The application of the plants was reported by 75 informants. From the 51 reported plants, 20 plants were frequently cited as having high potential anti viral and anti-inflammatory activity and were validated in in-silico approach. PASS was used for compound prediction, and AMT was calculated with the help of ADMET lab 2.0. Results: Out of the 20 plants validated in in-silico, the results of reported compounds revealed that Aeginetia indica could best act as an antiviral agent with Pa (0.939) and Pi (0.003), followed by Bacopa monnieri with Pa (0.880) and Pi (0.002) and Blumea balsamifera with Pa (0.743) and Pi (0.004). Subsequently, the plant which can act as the best anti-inflammatory ailment is Andrographis paniculata with Pa (0.845) and Pi (0.005), followed by Pisum sativum with Pa...
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Posted by admin on Apr 30, 2023 in |
Plant or crude oriented herbs formulated products when they were application for their aromatic property in cosmetic formulation which known as or termed as herbal cosmetics. Now days it increasing demand for the herbal product has created new avenues in the cosmeceuticals market. Before some era, all cosmetics items were formulated in the house. Natural or herbs materials like aromatic materials, spices, herbs, resins, dyes, fats, oils, and the natives of different countries used perfumes. Natural product or Herbal Cosmetics, here in after referred to as Products, are formulated, using different valuable cosmetic components to formulate the base in that one or more natural or herbal components are using to provide defined cosmetic advantageous only, shall be called or that known as “Herbal Cosmetics or natural cosmetics”. Different types herbal components/additives is using in natural formulations contain bleaching agents, fixed oils, perfuming agents, waxes, antioxidants, protective agents, herbal colorants, critical oils, and plant fabrics that include leaves, gums, mucilage, etc. Herbal preparation is preparing herbal substances which are side-lining...
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Posted by admin on Apr 30, 2023 in |
Vigna aconitifolia L. represents a genus in the Fabaceae family and is one of the most drought-resistant legumes, commonly grown in arid and semi-arid regions of India. Therapeutic effects of Vigna aconitifolia L. have been reported in several publications, but there are only a few reports on the biological activities of the Vigna aconitifolia L. proteins. In the present study, antibacterial activities of the Vigna aconitifolia L., peptides have been investigated. Homogenized seed flour was pulverized, and its protein content was extracted in a phosphate buffer. After centrifugation, by adjusting pH, peptides from the supernatant were isolated. Gel filtration (G-25) and Ion-exchange chromatography on the seed extract gave fairly pure peptide fractions of which inhibitory activities were done by agar well diffusion method against Shigella flexineri, Bacillus cereus, Salmonella typhimurium, Staphylococcus aureus, Enterococcus faecalis, Vibrio cholerae bacterial pathogens. The results indicate that a 30kDa of the peptide was identified and exhibited good antibacterial activity against bacterial pathogens. Among all strains, Shigella flexineri and Staphylococcus aureus exhibit good results with a clear zone of...
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Posted by admin on Apr 30, 2023 in |
The objectives of the present study were to determine the total phenolic content, flavonoid content, and anti-cataleptic activity of chloroform and methanolic extract of the roots of Quisqualis indica. The crude extracts were investigated for total phenolic and flavonoid content using the Folin-Coicalteu method and the Aluminum chloride colorimetric method. It was found that the total phenolic content is greater than the flavonoid content in Q. indica roots. The total phenolic content of a methanolic extract is greater than the chloroform extract as 61.83 μg/ml and 25.40μg/ml, respectively. The flavonoid content in methanolic and chloroform extract was found to be 10.22μg/ml and 2.11μg/ml. The anti-cataleptic activity of the Q. indica roots extracts was evaluated by Wood block test. Catalepsy was induced by clonidine 1 mg/kg, subcutaneously and Chlorpheniramine maleate 10 mg/kg i.p as the standard drug. The vehicle-treated group has shown maximum duration of catalepsy (190.33±3.68) at 180 minute after the administration of clonidine. There was significant inhibition of clonidine induced catalepsy in the animal pre-treated with methanol and...
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