Posted by admin on Apr 30, 2023 in |
Anti-diabetic medications, like insulin and glucagon-like peptide1(GLP-1) and its analogues are critical for diabetics to maintain blood glucose control. The difficulty of current insulin-based therapies for Type I & II diabetes mellitus, as well as the risks connected with fluctuations in blood glucose levels (hyperglycemia and hypoglycemia), served as the impetus for the establishment of “smart insulin” technology (glucose-responsive insulin; GRI). Insulin-dependent diabetes can be treated with glucose-responsive nanoparticles, a promising technology. The creation of nanoparticles of diverse sizes, features, and compositions allows for a variety of drug-delivery activities. When combined with a glucose measuring unit, this technology can give exogenous insulin more dependably and painlessly than conventional treatment. Nanoparticles made of polymers that are biocompatible and degradable have been created. These nanoparticles shield insulin from oxidation and make it easier for insulin to enter cells via a paracellular or transcellular pathway, whether or not they are linked to the nanoparticles. These techniques can potentially dramatically increase drug administration under controlled conditions, bioavailability, prolonged half-life, and clinical efficacy. The use...
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Posted by admin on Apr 30, 2023 in |
The current investigation was Developing and validating a novel, simple, responsive, and stable UPLC method for the measurement of active pharmaceutical ingredients of Cytarabine and Daunorubicin. The chromato-graphic strategy utilized a phenyl column of dimensions 100 x 2.1 mm, 1.7 micron, using isocratic elution with a mobile phase of acetonitrile and 0.1 percent formic acid (70:30) with a flow rate of 0.5 ml/min and the run time is 3min and a detector wavelength of 240 nm utilizing the PDA detector was given in the instrumental settings. The Retention time (Rt) of the Cytarabine and Daunorubicin were found to be 0.164min and 1.742 min. The proposed method was validated according to an international conference on harmonization (ICH) guidelines. The accuracy results of Cytarabine and Daunorubicin were found to be 100.4% & 99.8%, and the linearity of Cytarabine and Daunorubicin were 0.992 & 0.990. Precison results of Cytarabine and Daunorubicin were 0.69 and 0.52 and the LOD and LOQ values of Cytarabine 1.65µg/ml, and 5µg/ml and Daunorubicin are 0.726µg/ml and 2.2...
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Posted by admin on Apr 30, 2023 in |
Jaundice is defined as the yellowing of the skin and whites of the eyes which are caused by a buildup of a substance called bilirubin in the blood and tissues in the body. Bilirubin is a yellowish pigment formed by the breakdown of heme, which occurs largely in hemoglobin and red blood cells. The purpose of this study was to analyze and compare the knowledge, attitude, and perception of jaundice among paramedical and non-paramedical students. A Comparative cross-sectional study was conducted in South India for a period of 6 months from May 2021 to October 2021. The Knowledge, Attitude, and perception questionnaire was used to obtain respondents’ information. The data collected were tabulated, analyzed, and interpreted using standard statistical tools. The statistical procedure was undertaken with the help of the statistical package Instat and Prism version 6.0. The comparison was done by the Chi-square test. A total of 818 students were selected and divided into two groups such as 409 paramedical students and 409 non-paramedical students. This study concluded...
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Posted by admin on Apr 30, 2023 in |
Enzymes are biocatalysts that accelerate biotic reactions positively or negatively. Proteases are small types of enzymes that cleave peptide bonds. These proteases can be produced by microbes (fungi, bacteria, and viruses), plants, and animals. The catalytic site is only visible from the outside and is broadly dispersed on the surfaces of different cell types. Based on the position of the cleavage site in the putative substrate, these peptidases can be classified as endopeptidases or exopeptidases. These peptidases are used in a variety of industries, including laundry detergents, leather and fabric processing, food processing, baking, flesh tenderization, food additives, artificial sweetener synthesis, feed, cheese making and the dairy industry, soy sauce production, brewing and cereal processing, photography, environmental bioremediation, medical and pharmaceutical industries, plant pathology, nitrogen production, and so on. Proteases are classified based on physiological roles. Extracellular proteases breakdown down large proteins into smaller parts on the other hand, intracellular proteases helps in the regulation of...
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Posted by admin on Apr 30, 2023 in |
The in-vitro drug release profile from a hydrophilic matrix tablet is influenced by the viscosity of the gel layer formed due to its polymer hydration, and it depends on various other physical properties like a drug: polymer ratio water-solubility and particle size of the drug, particle size and type of the polymer, type of diluents used, and temperature of media. The drug release profile of different formulations i.e., C1to C6 formulated by utilizing Hypromellose K4M, Hypromellose K15M and Hypromellose K100M Respectively. K4M, which is low viscosity polymer, shows a faster release at initial time points. Hypromellose polymer (K100M) is hydrophilic in nature, showing fast hydration and controlling the dissolution profile. The dissolution profile of batch C1 to C2 having drug (Metformin HCl): polymer ratio 1:0.25 and 1:0.5 gives little controlled release profiles of the drug in C1, C2. Hence, 1:0.5 drug (Metformin HCl) to HPMC K100M was used for further study. It had been observed that HPMC K15M and K4M could not retard the release rate sufficiently to get...
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