Posted by admin on Mar 31, 2023 in |
Background: Type 2 diabetes mellitus is increasing very rapidly in India, yet studies regarding knowledge, attitude and practices in diabetes in various Indian communities, especially in the Northeastern region, are limited. It is essential to understand the current gaps in knowledge and problems with the attitude and perceptions of the general population regarding diabetes to effectively plan public health policies. Objective: To assess the knowledge, attitude and practice of type 2 diabetes mellitus (T2DM) patients at Silchar Medical College and Hospital, Silchar, Assam. Materials and Methods: A prospective, cross-sectional, questionnaire-based study was done among 161 patients attending Medicine OPD at Silchar Medical College and Hospital, Silchar, Assam. The study participants were selected using a random sampling method and data were collected through a questionnaire. Results: Out of 161 patients, 66% were male, 34% were female. 70% of the population fell in the 41-60 years age group. 23% of the participants think that diabetes is infectious. 63% of the population believes that insulin is habit-forming and should be avoided. Regular...
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Posted by admin on Mar 31, 2023 in |
The present study aimed to synthesize Carbazole boronic acid derivatives and determine their efficacy in treating breast cancer using the MCF-7 cell line. Nine different derivatives (C1-C12) of boronic acid were prepared i.e. 9-ethyl-(9H-carbazol-3-yl)-boronic acid (C1); (9-benzyl-9H-carbazol-3-yl)-boronic acid (C2); [9-(4-fluorobenzyl)-9H-carbazol-3-yl]-boronic acid (C3); [9-(sec-butyl)-9H-carbazol-3-yl]-boronic acid (C4); (9-pentyl-9H-carbazol-3-yl)-boronic acid (C5); (9-octyl-9H-carbazol-3-yl)-boronic acid (C6); (9-cyclopentyl-9H-carbazol-3-yl)-boronic acid (C7); [9-(4-chlorobenzyl)-9H-carbazol-3-yl)-boronic acid (C8); and [9-(2,4-dichlorobenzyl)-9H-carbazol-3-yl)-boronic acid (C9). Results showed that C3, C7, C8 and C9 exhibited more than 90% inhibition of cancer cell growth in MCF-7 breast cancer cell line. The percentage yield of these compounds was 20%, 26%, 24% and 24%, respectively. However, other compounds have also shown good anticancer properties compared to the control group. Thus, these compounds have shown potential in in-vitro studies and can be used as an anticancer drugs after pre-clinical and clinical...
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Posted by admin on Mar 31, 2023 in |
Parkinson’s disease has been a challenging neurodegenerative disorder for researchers and clinicians alike for decades. Though L-dopa has changed the management of PD to a considerable extent, effective solutions remain elusive since L-dopa, after a few years, partly loses its efficacy and develops dyskinesias as a complication, incapacitating the patient. Also, existing PD animal models using MPTP, rotenone, paraquet, etc cause significant suffering to the animals and also require a minimum of 22–25 days for induction. Hence, a better PD animal model was conceived considering the synergistic oxidative stress lipids, and rotenone induce on striatal neurons. The experiment compared the existing rotenone induction with combined rotenone and high-fat diet induction, carefully watching for motor and behavioural symptoms of PD in the Wistar rats in addition to measuring the biochemical profiles for toxicity, strictly following the ARRIVE guidelines for animal research. This study found that using HFD+Rot for induction not only shortened the duration of induction to a mean of 14 days but also reduced the suffering by reducing the...
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Posted by admin on Mar 31, 2023 in |
For almost five decades, from its application in preserving blood plasma to stabilizing pharmaceuticals and biopharmaceuticals, lyophilization has been used in life sciences. Lyophilization is a popular drying technique for preserving various drugs, formulations and biological materials such as proteins, plasma, and living cells. The researchers have made significant efforts to develop lyophilized nanoparticulate drug delivery formulations. During lyophilization, biological products and vaccines could be increased by removing solvents and the shelf-life of injectables. Thus, lyophilization unstable or heat-sensitive drugs/biologicals can be dried at low temperatures without damaging their physical structure. Lyophilized products can be reconstituted quickly and easily, improving shelf life and easy transportation. Vast applications of lyophilization in the Pharmaceutical Area established the importance of lyophilization techniques in the pharmaceutical field. The present review aims to update recent and advanced applications of Lyophilization techniques in Pharmaceuticals and biological products such as Antibiotics, Vaccines, proteins, enzymes, and...
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Posted by admin on Mar 31, 2023 in |
A series of novel (Z)-3-((5-(2-((E)-arylidene) hydrazine-1-carbonyl)-4-methylthiazol-2-yl)amino)-2-cyano-3-(methylthio) acrylate 4a-t molecules have been synthesized and characterized by 1H NMR, 13C NMRand mass spectral analysis. Starting from ethyl 2-amino-4-methylthiazole-5-carboxylate 1 was reacted with hydrazine hydrate to obtain carbohydrazide molecule 2. Furthermore, reaction of molecule 2 with various aldehyde and the adduct 3a-t formed was reacted with ethyl 2-cyano-3,3-bis(methylthio) acrylate to get novel thiazole derivatives 4a-t, furthermore it was reacted with lithium hydroxide to form acid containing novel thiazole molecule 5a. The significant features of this reaction procedure are novel, easy and less time consuming with analytically pure product...
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