Posted by admin on Mar 31, 2023 in |
Numerous disorders are caused by inflammation, and recent epidemics have prompted public health concerns. The fact that there are so many anti-inflammatory medications available doesn’t change the fact that they frequently don’t work because they pose a severe risk of gastrointestinal toxicity with both acute and chronic use, hematologic toxicity with acute use, and nephrotoxicity with chronic use. Curcumin’s clinical value was, however, constrained by its low absorption. Therefore, it is crucial to find new anti-inflammatory medications, and natural products are a great place to start. One such natural substance, curcumin, is a promising therapeutic candidate because of its stability, solubility, and low toxicity. Research has indicated its inhibitory effect on prostaglandin E2 and COX-2 protein formation, as well as on phorbol ester- and CD-induced COX-2 mRNA expression and PGE2 synthesis, among other things. The mechanisms either entail inhibiting cyclooxygenases (COX) and other inflammatory enzymes. This study covers the current state of knowledge with an emphasis on the anti-inflammatory properties of curcumin and their potential molecular...
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Posted by admin on Mar 31, 2023 in |
The whole plant of Biophytum reinwardtii (Zucc.) Klotzsch (BR) and Biophytum veldkampii A.E.S. Khan & et al. (BV) were evaluated for their antioxidant activities, total phenolic content (TPC), and total flavonoid content (TFC). The plants were successfully extracted with varying polarity solvents like pet ether, chloroform, ethyl acetate, and ethanol. Phytochemical evaluation of various extracts revealed the occurrence of alkaloids, carbohydrates, phenolic compounds, tannins, and flavonoids. The TPC was estimated by the Folin-Ciocalteu method and indicated that the maximum amount was present in ethyl acetate extract of BV (61.06 mg of GA/g of extract) followed by BR (60.08 mg of GA/g of extract). The TFC was highest in the ethyl acetate extract of BV (106.67 66 mg of RU/g of extract), followed by BR (96.66 mg of RU/g of extract). In in-vitro studies, ethyl acetate extract showed maximum activity. For BR, the IC50 value of DPPH radical, Nitric oxide radical, ABTS radical, Superoxide radical, and Hydrogen peroxide radical scavenging activity was found to be 48.95, 60.72, 54.85, 58.53, and...
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Posted by admin on Mar 31, 2023 in |
Since ancient times, plants have been used for medicinal purposes for their various therapeutic potentials and safest to modern allopathic medicines. Regularly phytochemicals are proving to be modern medicine with novel drug delivery systems by treating different diseases and disorders. Phytochemical compounds need improvement of efficacy and patient’s compatibility to deliver in various diseases, e.g., high blood pressure, microbial, coronary heart disease, cancers, diabetes, inflammation, etc., also require a rational approach. Nanotechnology is a promising drug delivery approach for targeted or site-specific phytoconstituent delivery. Especially, Nanogels are the most rational approach for targeting skin diseases and enhancing bioavailability. Phytoconstituents or plant extract-loaded nanogels have been reported in in-vitro and in-vivo activities for different skin disorders like aging, acne, skin infection, etc. Nanogels, as a novel drug delivery system, may reduce toxicity and improve the bioavailability of the incorporated drug. The present review is focused on various phytomedicines that have been used in treating skin aging and acne, nanogel formulations prepared, and the effectiveness of both phytochemicals and nanotechnology for...
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Posted by admin on Mar 31, 2023 in |
Background: Warfarin is an anticoagulant widely used to prevent thromboembolic events (TEs) in patients with various cardiovascular (CV) diseases. Pharmacogenomics (PGx)-guided testing is a growing method suggested to help predict warfarin dosing. A systematic review was performed to compare the incidence of thromboembolic events (TEs), bleeding events (BEs), time in therapeutic range (TTR), the proportion of time to therapeutic range (PTTR) and warfarin dose adjustments between PGx-guided warfarin therapy and standard of care (SOC) in patients with non-valvular atrial fibrillation (Afib), pulmonary embolism (PE), and deep vein thrombosis (DVT). Methods: Two reviewers independently searched MEDLINE, CINAHL, Web of Science, Embase, Cochrane Library and clinicaltrials.gov databases from October 2019-August2022 to identify studies. Abstracts were reviewed for outcomes of interest and patient demographics to identify patients present with International Normalized Ratio (INR) readings, TTR, PTTR, BEs and TEs. Results: From the database search, 28 articles were retrieved based on abstract screening. A total of 6 articles were ultimately selected for the systematic review. All articles found favor in the PGx-guided group...
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Posted by admin on Mar 31, 2023 in |
Urolithiasis, also called kidney stone, was caused by a missense mutation in the adenine phosphoribosyl transferase enzyme encoded by the APRT gene. This gene was present in human chromosome 16. In this paper, a comparative study of the effectiveness of six ligands reported in Synadenium grantii was analyzed by docking approach. For this purpose, the effective six ligands that were present in Synedenium grantii were selected, downloaded, and docked with APRT. The interactions of these ligands with APRT were analyzed by docking by using Autodock vina. The selected six ligands were phorbol ester, terpene, flavonoid, tannin, coumarin, and anthraquinone. All these ligands have anti-urolithiatic activity and are used to treat urolithiasis. A docking study by AutoDock vina reveals the interacting amino acid residues that have not been reported yet. Based on interactions of different ligands with APRT, our analysis shows that flavonoid was most effective, followed by terpene, phorbol ester, tannin and coumarin. The results show that anthraquinone was the least effective. The docking study performed by Autodock vina...
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