Posted by admin on Mar 31, 2023 in |
The main objective of the current study was to see whether SG peel methanolic extract had antidiabetic and hepatoprotective results in streptozotocin-induced diabetic rats. Streptozotocin was administered intraperitoneally to rats to trigger diabetes. When rats had an elevated blood sugar level three days after acquiring streptozotocin, it was determined that they were diabetic. Diabetic rats were given pre-determined doses of a methanolic extract of SG. Our experimental study took 28 days to complete. Rats were fasted overnight for an oral glucose tolerance test, and antioxidant parameters were measured. Rats were euthanized after 28 days to perform histopathological tests. One of the three doses of methanolic extract of SG peels (50, 100 and 200 mg/kg) showed nearly identical findings to Glibenclamide (2.5 mg/kg). After administering sponge gourd peel extract doses, blood glucose levels were found to be depleted. The positive impact on HOMA-IR and HOMA- β, plasma insulin levels, glycated haemoglobin, and several other variables. Furthermore, antioxidant parameters, including GLUT2 and SGLT1, significantly improved in diabetic rats. Finally, in Streptozotocin-induced...
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Posted by admin on Mar 31, 2023 in |
Depression is accepted as a condition of misery and is treated as a disorder that includes mental and emotional disorders. Depression is a deadly disease that affects about 5% of the general population. In addition, depression is a heavy burden on patients and families. Furthermore, many epidemiological studies have shown that the occurrence of depressive disorders in the general population is increasing at an alarming rate. Depression is the most common form of emotional disorder, from a very mild condition to severe depression associated with hallucinations and delusions. In addition, altered levels of serotonin and other biogenic amines have also been shown to contribute to neuromodulatory disturbance in the etiology of depression. According to monoamine theory in depressive disorder, patients with major depression have shown biochemical symptoms which may change monoamine neurotransmitters, specifically nor-epinephrine and serotonin. Clinical data suggested that dopamine is also involved in the pathophysiology and treatment of...
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Posted by admin on Mar 31, 2023 in |
The present study evaluated the antibacterial and antifungal activities of the medicinal plant Bauhinia vahlii. The antibacterial and antifungal activities of vacuum dried ethanol extract of the stem and leaves of Bauhinia vahlii (EEBVS and EEBVL) were performed using the Disc diffusion method. The antibacterial and antifungal activities recorded significant effects against five bacterial strains, including Staphylococcus aureus, Bacillus subtilis, Escherichia coli, Pseudomonas aeruginosa, Salmonella typhi and two fungal strains, including Candida albicans and Aspergillus niger. The ethanol extracts of Bauhinia vahlii stem and leaves were showed the significant antibacterial effect of different bacterial strains and antifungal activity of fungal strains in the ethanol extract of stem (14 mm) but more activity observed in the ethanol extract of leaves (17 mm) in the Escherichia coli bacterial strain against different bacterial strains as compared to standard drug Amikacin (19 mm) whereas more potent in ethanol extracts of leaves (19 mm) in the fungal strain Candida albicans as compared to standard drug fluconazole (21 mm) as observed by zones of inhibitions...
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Posted by admin on Mar 31, 2023 in |
The current study aims to develop a reversed-phase HPLC method for quantifying the active substances of Fenticonazole Nitrate (FENTI), Tinidazole (TINI) and Lidocaine base (LIDO) simultaneously and to validate the proposed method for the intended analytical application in the bulk and pharmaceutical dosage form by ICH guidelines. In this work, the behaviour of f FENTI, TINI and LIDO was studied under various degradative conditions, and a stability-indicating LC method was developed to separate the degradation products and quantify the drug in their presence. The mobile phase Phosphate buffering agent: Methanol: Acetonitrile (60:30:10; v: v: v), Hypersil Phenyl type silica column, with flow rate 1.0ml, detection wavelength 210nm, column temperature at 40ºC and Methanolis used as diluents. System Suitability, Specificity, Precision, Linearity, Accuracy, and Robustness parameters were all validated. The system suitability parameters were investigated by injecting the standard six times, and the results were well below the acceptance threshold. Linearity parameter was investigated at levels ranging from 80% to 120%, with a r2 value of 0.999 discovered. The formulation...
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Posted by admin on Mar 31, 2023 in |
The preparation of metal-based Indian traditional drugs involves the conversion of pure metal into its therapeutically effective form. “Tamra Bhasma” (calcined copper) is one such herbometallic preparation used for various medical conditions like anaemia, obesity, and skin disease, disorders of the liver and spleen, hyper-acidity, rhinitis, hemorrhoids. A detailed evaluation of the changes occurring during each step of pharmaceutical processing, factors affecting the type of Puta and its physicochemical characterization has been examined in the present work. The pharmaceutical preparation of “Tamra Bhasma” (TB) includes quenching in liquid media, then boiling in liquid, followed by calcination and finally to remove the leftover blemishes, potentiation is carried out. Traditional Puta (the process of controlled heating and cooling) system has been used for its calcinations and Kajjali and Gandhaka have been used as media for calcinations of Tamra. TB has been subjected to different physicochemical characterization using XRD and SEM-EDXA. The result suggests that Bhasma Parikshas (confirmatory tests) are the most reliable criteria to authenticate the formation of a good quality...
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