Posted by admin on Mar 31, 2023 in |
Nanotechnology is an interdisciplinary field of science that refers to the research and technology development at atomic, molecular, and macromolecular scales, which leads to the controlled manipulation and study of structures and devices with length scales that range from 1nm to 100 nm. During the past few decades, a surfeit of nanomaterials (NMs) and nanoparticles (NPs) has evolved and been evaluated for their potential to improve the clinical treatment and diagnosis of a patient as diagnostic and therapeutic agents. Real exposure has been generated around the probable effects of the NMs and NPs for novel therapeutic approaches against several diseases, including cancer, to cope with the threats of the malignant tumour. Few nanoparticles also exhibit strong antimicrobial activity against Gram-positive and Gram-negative bacteria and act as antibacterial agents for treating different bacterial infections. A wide variety of nanomaterials, both carbon nanomaterials (CNMs) such as graphene, fullerenes, carbon nanotubes, and metal nanoparticles (MNPs), including gold, silver, and zinc oxide with distinctive physicochemical properties, provides opportunities to be explored in the...
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Posted by admin on Mar 31, 2023 in |
Itraconazole is a triazole antifungal category drug used for the treatment of local &Systemic fungal infections. Itraconazole is not recommended to neutropenic and other immune-compromised patients who have difficulty swallowing the oral capsule formulation, and it has many side effects. Commercially, Itraconazole topical gel preparation is not available in the market; thus, this formulation is made for better patient compliance, reduces the drug dose, and avoids side effects like liver damage and kidney damage avoiding first-pass metabolism. The gel was formulated by preparing nanocomposite with polymer inclusion complex by microwave-induced diffusion technique. Which ultimately results in enhancing the water solubility of nanocomposites. The resultant polymer-based nanocomposite retains the inherent properties nanoparticles, while providing higher stability, and this nanocomposite is incorporated into the gel base. Prepared nanogel Prepared nanogel is characterized by pH determination, Spreadability, Viscosity measurement, In-vitro diffusion, antifungal activity. Among the formulation, F3 was selected as the best formulation having % CDR of 76.57 % & more Antifungal activity than the marketed formulation. The results indicated that nanocomposite-based...
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Posted by admin on Mar 31, 2023 in |
Wound healing is a normal and common process that typically involves overlapping roles to increase normal activity by increasing neutrophils. The healing process can be managed by using natural substances that have therapeutic properties. The activity of numerous proteins and their regulation by genes orchestrate a healing performance like no other. The present study is to learn about the recent advances and groundbreaking research into herbal formulations for wound healing. Searching Scopus, PubMed, Science Direct, Cochrane Library, Medicine, and Google Scholar for herbal formulations of pharmaceuticals yielded the greatest results. Prisma analysis was used to identify exclusions in RCTs and cohort studies, while CMA performed a meta-analysis. Two reviews were rated on a 3-item, 5-point scale. Subgroup analysis is done to maximize competitive advantages to check for bias. Herbal wound healing formulations have 682 clinical studies. After duplication, 233 records were omitted from the result array, and 22 out of 89 articles were essential. Descriptive and analytical analyses of 16 clinical trials. Consider high, medium, and low bias risks...
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Posted by admin on Mar 31, 2023 in |
Objectives: Cyclophosphamide is an alkylating agent known for its reproductive toxicity in males. This study evaluates the protective effects of Withania somnifera extract (WSE) on cyclophosphamide (CP) induced testicular toxicity and DNA damage in male rats. Methods: Adult male rats were randomly divided into four groups Group1-Control, Group 2- Cyclophosphamide, Group 3- Withania somnifera extract, Group4- Cyclophosphamide+ Withania somnifera. After the experimental period of 8 weeks, sperm quality, hormonal analysis, and DNA damage studies were carried out. Histopathological analysis of testes was performed for the assessment of spermatogenic disorders. Results: In CP-treated rats, sperm quality was reduced with decreased testosterone levels with increased DNA damage. Co-administration of WSE with CP improved sperm quality, testosterone levels, spermatogenesis and genotoxicity of cyclophosphamide. The histopathological study also restored most of the degenerative and necrotic changes. Conclusions: This study suggests a prominent role of WS against CP-induced testicular toxicity and DNA...
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Posted by admin on Mar 31, 2023 in |
Hyperlipidemia is an elevated condition of lipid levels in the body and is known to speed up a process of atherosclerosis that may prove fatal in the development of various cardiovascular diseases. The figures of the patient with hyperlipidemia are constantly increasing which is rising a serious risk factor for a group of cardiovascular diseases. Although various pharmacotherapy for hyperlipidemia namely statins, niacin, fibric acid derivatives, cholesterol absorption inhibitors, and bioactive are available but suffer from various hurdles such as inadequate solubility and poor absorption leading to low bioavailability and ineffectiveness in lowering of cholesterol levels only up maximum 40%. Hence it is required to combat these hurdles associated with hyperlipidemia. Nanotechnology has provided revolutionary changes in medicine, providing a novel approach to treating hyperlipidemia. Various nanotechnology-based approaches include nanosuspension, nanoemulsion, nanoparticle, polymeric nanoparticle, dendrimer, polymeric micelle, etc. out of which nanosuspension has provided a strong background to combat the hurdles linked with pharmacotherapy due to possession of various benefits such as improved aqueous solubility, enhanced bioavailability, fast onset...
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