Posted by admin on Feb 28, 2023 in |
Background: The current study assessed the effect of an Antineoplastic-loaded transdermal patch in Dimethyl-benzanthracene (DMBA)-induced breast cancer. Materials and Methods: Different formulations composed of various concentrations of tamoxifen citrate, poly (SA: RA), glucose, and mannitol were formulated and evaluated in DMBA-induced breast cancer in female albino Wistar rats. Multiple parameters were evaluated, such as body weight, hemoglobin content, red blood cell, white blood cell, SGPT, and SGOT. Results: Treatment with formulations showed a decrease in body weight compared to disease. Equally, a considerable increase in hemoglobin was observed in the formulation-treated group over the disease grouping. Likewise, there is a decrease in SGPT and SGOT in formulation compared to disease. Conclusion: The present study revealed a transdermal patch loaded with tamoxifen showed promising antitumor...
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Posted by admin on Feb 28, 2023 in |
Mercury is the more risky heavy metal for human health because of its ability to kill human nerve cells and its exposure to the environment through human activities, which implicate sewage drainage, agriculture, municipal, mining, incineration, and drainage of industrial wastewater. Mercury and its compounds cause toxic action in the body by several mechanisms, which mainly cause the nervous system through their molecular and cellular effects. The present research intended to investigate the ameliorative potential of betulinic acid and rotundic acid against mercuric chloride (HgCl2) (1.29 mg/kg b. w.) induced neurotoxicity in adult male rats. The examination was implemented in male albino Wistar rats (n = 36). Which was partitioned into six gatherings as follows: Control, HgCl2, HgCl2 + betulinic acid, HgCl2 + rotundic acid, betulinic acid alone, and rotundic acid alone. The results revealed that intense HgCl2 regulation modified different biochemical specifications incorporated with the high volume of lipid peroxidation (LPO) portion and a significantly depleted level of reduced glutathione (GSH), superoxide dismutase (SOD), catalase (CAT) and glutathione...
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Posted by admin on Feb 28, 2023 in |
Objective: The present research work was to formulate optimize and evaluate hydrocortisone-loaded niosomal gel for the management of rheumatoid arthritis. Method: Niosomal gel was successfully prepared by lipid-thin film hydration process and optimized by using 23 full factorial designs using three independent variables (tween 80 concentration, cholesterol concentration, and sonication time) and three dependent variables (cumulative drug release, mean particle size and entrapment efficiency). The effect of all variables was assessed by response surface methodology. Results: The prepared formulations were evaluated in terms of particle size, in-vitro drug release, encapsulation efficiency, zeta potential, viscosity, and spreadability. Based on response surface methodology, S6 formulation was found to be the best formulation with entrapment efficiency of 92.27%, in-vitro drug release of 75.61% in 8 hrs, and mean particle diameter of 121.58 nm. The stability studies indicated that all the formulations are stable as none exhibited significant drug content change over time. Conclusion: The study indicated the successful development of hydrocortisone-loaded niosomal gels with improved penetration, good homogeneity, and enhancement of duration...
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Posted by admin on Feb 28, 2023 in |
Statins are the first line of defense in the treatment of dyslipidemia and hypercholesterolemia illness. HMG-CoA reductase inhibitors or statins are the most widely prescribed drugs for persons at risk of cardiovascular disease. Cardiovascular disease (CVD) is the leading cause of death and a major cause of morbidity around the world. Statins have the same mechanism of action, but their chemical structures, pharmacokinetic profiles, and lipid-modifying potency differ. Triglycerides, cholesterol, and low-density lipoprotein (LDL) levels in the blood are all known risk factors for vascular disease, but statin drugs help to increase high-density lipoprotein (HDL) levels in our bloodstream. Some of the drugs utilized include rosuvastatin, atorvastatin, simvastatin, and pravastatin. According to clinical data, rosuvastatin is the most effective drug for decreasing low-density lipoprotein cholesterol and triglycerides, followed by atorvastatin, simvastatin and pravastatin. A brief review of the analytical methods developed from 2001-2021 for the estimation of Antilipidemic drugs has been discussed in the present study. This study will help the researchers to develop better methods for this class...
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Posted by admin on Feb 28, 2023 in |
Tumor hypoxia is an important pathological condition that influences several signaling cascades in malignant cells, eventually leading to therapy resistance. Several natural bioflavonoids hold promise as anti-cancer agents. However, the effect of Quercetin on hypoxic pancreatic cancer cells is unknown. We analyze the effect of Quercetin on expression levels of metastatic markers HIF1α and E-cadherin under hypoxic conditions. Quercetin treatment was significantly correlated with reduced HIF1α expression levels and elevated E-cadherin levels. Our results suggest that Quercetin may alter E-cadherin levels by regulating HIF1α expression. Quercetin may inhibit pancreatic cancer cell metastasis by regulating metastasis genes in a hypoxic microenvironment and has pharmacological potential in aggressive pancreatic cancer...
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