Posted by admin on Sep 30, 2024 in |
Apart from the API, the excipient plays a crucial role in a formulation because of their versatile application, which enhances different physical and chemical characteristics in a dosage form. At present scenario natural polymers are considered a leading constituent as an excipient to formulate several innovative approaches for designing the drug delivery system. The components which are obtained from nature is always preferred for our health due to their fewer side effects. Hence, biopolymers have the additional privilege of being incorporated as an excipient in pharmaceutical formulations. Demand for natural polymers is enhancing day by day (increased 7.1% in every year as per scientific data) because of their versatile application in drug delivery systems and multiple utilization of several domains in the biomedical section. Low toxicity, compatibility, sustainability, biodegradability, swelling index, release pattern are the major Parameters of the biopolymers which alter the different pharmacokinetic and pharmacodynamic characteristics of a pharmaceutical dosage form. The major aim of this current review is to impart some knowledge related to the widespread...
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Posted by admin on Sep 30, 2024 in |
Heat stress disrupts the delicate thermoregulatory setup of human body, activating various molecular pathways (reduction in uric acid production via polyol-fructokinase pathway, elevated levels of reactive oxygen species (ROS) causing oxidative stress, intracellular calcium overload associated with mitochondrial dysfunction, and diminished nitric oxide (NO) causing vascular endothelial injury) that contribute towards Heat Stress Nephropathy (HSN).This study was designed to investigate the nephroprotective potential of Green Tea Extract (GTE) and Hesperetin (HES) in HSN. Mice subjected to heat stress (39.5oC for 30 minutes, twice a day for 10 days) along with 2, 4-Dinitrophenol (DNP) were used as a nephropathy model. Furthermore, pretreatment with GTE (50mg/kg; s.c) and HES (50mg/kg; s.c) were done simultaneously followed by heat stress procedure. Results demonstrated a significant improvement in kidney function, as evidenced by reduced levels of Blood Urea Nitrogen (BUN) and Serum Creatinine (sCr) in mice pre-treated with GTE and HES compared to heat- stressed animals. Moreover, this combination led to a decrease in Thiobarbituric reactive substances (TBARS) levels while enhancing Superoxide dismutase (SOD)...
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Posted by admin on Sep 30, 2024 in |
A developing class of medications called biosimilars is created to be used interchangeably with biologics. In living cells, biologics are often large, complicated proteins with a range of potential applications. Biologics are utilised to treat malignancies, endocrine problems, and inflammatory bowel diseases just within the discipline of gastroenterology. Despite the fact that many diseases can be effectively treated or managed with biologics, patient access is frequently constrained by their high cost. The creation of biosimilars is an effort to lower the cost of medical care. In terms of efficacy, side effect risk profile, and immunogenicity, biosimilars must be essentially equivalent to their reference biologics. Biosimilars go through fewer clinical trials than their reference biologics, despite the manufacturing process still requiring manufacture within living cells. As a result, the biosimilar medication is less expensive to produce and purchase than the reference biologic. Seven biosimilars have currently received FDA approval for use in the treatment of Crohn’s disease, ulcerative colitis, and colorectal cancer. There are further biologics used to treat gastroenterological...
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Posted by admin on Sep 30, 2024 in |
Objectives: Moringa oleifera has enormous attention as the ‘natural nutrition of the tropics and an essential food commodity. Antioxidants important in deactivating free radicals having damaging role on biological cells. Polyphenolic compounds are the most prevalent antioxidants seen in plants. Present study aims to evaluate the antioxidant and antitumor effect of ethanolic leaf extract of Moringa oleifera (ELMO) against Ehrlich’s ascites carcinoma bearing Swiss albino mice. Materials and Methods: 500 mg/kg body weight of ELMO was administered once in a day about 15 days after 24hrs of tumour inoculation. In mice treated with ELMO we observed decreased body weight, abdominal circumference and tumour volume, when compared to Ehrlich’s ascites carcinoma control mice. We also observed in mice Treatment with ELMO decreased levels of lipid peroxidation (LPO) and increased levels of (GSH), and superoxide dismutase (SOD). Results: Mice treated with 500mg/kg body weight of ELMO have shown a significant decrease in both the protective and curative group of body weight, tumour volume, and abdominal circumference compared to the Ehrlich’s ascites...
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Posted by admin on Sep 30, 2024 in |
Background: Hepatitis B (HB) is a global public health issue that needs to be addressed. This study aims to assess Knowledge, Attitude and Practice (KAP) towards Hepatitis B and its vaccination status among undergraduate medical students of Govt. Medical College, Almora in Kumaon region of Uttarakhand. Material & Methods: An institution-based cross-sectional study was conducted at Government medical college, Almora in which 299 students were enrolled. Data was collected via Google form link. Results: In the present study, out of 299 students, 104 were male and 95 were females. It was found that students had good knowledge regarding Hepatitis B virus but there was a bit gap between knowledge, attitude and practice towards hepatitis B virus and its vaccine that need to be addressed. Conclusion: In the present study, near about half of the participants had good knowledge, attitude, and practice (KAP) regarding Hepatitis B. Education regarding Hepatitis B need to be imparted for prevention and timely...
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