Posted by admin on May 31, 2024 in |
The contemporary generation utilizes specific pharmaceuticals to treat ailments, irrespective of their detrimental effects on genetic material. More specifically, the lifestyles of expectant mothers and the medications they come across during pregnancy, such as antiemetic, antacid, antihistamine, analgesic, antibacterial, diuretic, sedative, and other medications, exert a significant influence on the utilization of these drugs. Certain pharmaceuticals require a period of 30 to 60 minutes to reach equilibrium in maternal and fetal circulation, albeit at different concentrations and under varying conditions. Variables, including placental potency, dosage, maternal characteristics, drug efficacy, and gestational age at the time of exposure, contribute to the impact of drugs on the fetus. Notably, during the initial three weeks of pregnancy, a developing fetus is more susceptible than the mother. The National Institutes of Health (NIH) has documented spontaneous abortion, allergies, preeclampsia, gestational diabetes, hypertension, depression, and anxiety, as well as mild to severe functional or metabolic abnormalities as commonly reported complications during pregnancy. This review aims to ascertain the transplacental genotoxicity associated with medications employed...
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Posted by admin on May 31, 2024 in |
The antidiabetic and antioxidant efficacy of traditional medicinal plants from North-Eastern India remains largely unexplored. This study seeks to address this gap by examining the properties of 11 such plants. The plant samples were subjected to extraction using four different solvents. Their antidiabetic potential was evaluated through in-vitro α-glucosidase and α-amylase inhibition bioassays, while the antioxidant activity was assessed using the DPPH Scavenging assay. The results were compared to the standard antidiabetic drug, acarbose. Out of the 11 plants, five species demonstrated significant antidiabetic properties, inhibiting more than 50% of α-glucosidase and α-amylase enzyme activities. The petroleum ether tuber extract of Stephania glandulifera exhibited the highest α-glucosidase inhibition (99%), followed by the methanol leaf extract of Begonia roxburghii (94%) and the water leaf extract of Antidesma acidum (85%). In the α-amylase inhibition assay, Equisetum debile methanol extracts showed a 64% inhibition, followed by the leaf extract of A. acidum with a 62% inhibition in the methanol leaf extracts. Comparatively, methanol and water leaf extracts of Debregeasia longifolia displayed 64%...
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Posted by admin on May 31, 2024 in |
Objective: This study aimed to carry out a phytochemical, pharmacognostic, qualitative, and quantitative evaluation of the medicinal plant Psidium guajava L., also known as guava, a member of the Mytaceae family. Methods: The present study provides pharmacognostic, phytochemical, and quantitative details of Psidium guajava L. Results: Plant-dried stem powder material was subjected to continuous hot extraction Soxhlet using solvents pet-ether, acetone, and ethanol. Phytochemical standardization was undertaken to detect the presence of bioactive agents along with TLC. Different physical parameters, like ash values, extractive value, loss on drying, etc., were evaluated for the powdered drug. The extracts were obtained from the Soxhlet method and subjected to preliminary phytochemical evaluation. Conclusions: The results of this study can serve as a valuable source of information for identifying this plant for future investigation and...
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Posted by admin on May 31, 2024 in |
Hemidesmus indicus (H. indicus), also known as Indian Sarsaparilla or Anantmul, is a plant with diuretic, demulcent, and diphoretic properties. It treats various illnesses, detoxifies the blood, and reduces Vata, Pitta, and Kaphadoshas. It has been shown in pre-clinical trials to reduce illnesses in everyday clinical practice. In order to effectively promote this herbal medicine, clinical trials and patient studies conducted in hospitals are necessary. The intent of this review is to update the numerous medicinal qualities of H. indicus and demonstrate its therapeutic potential, enabling it to be used as an alternative to contemporary or modern medicine to treat a variety of disorders. The taxonomy, pharmacological components, and unique medicinal qualities of H. indicus are all outlined in this paper. It showed a proven effective and beneficial on the long-standing illness, therefore the need of the multicentre clinical trials is needed on the herbal medicine to be used as a complementary approach in...
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Posted by admin on May 31, 2024 in |
Rheumatoid arthritis (RA) is an autoimmune disease associated with chronic inflammation of the joints. If it is untreated then it leads to destruction of joints, erosion of cartilage and bone and eventually leads to loss of physical function. Since, RA is not complete curable disease, the treatment goals are to reduce the pain and stop/slow further damage. With advancement in the field of molecular biology, a better understanding of disease mechanisms is available which can help in the designing of more effective treatments. Old treatment modes have been optimized and new ones have been produced. Nowadays, different classes of drugs with different mechanism of action are available to control the inflammation and to achieve remission. The aim of this review is to discuss previous and present treatment options for treating RA and its...
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