Posted by admin on May 31, 2024 in |
This review covers the research on the anticonvulsant properties of marketed drugs with their side effects and adverse drug reactions and the importance of medicinal plants and homeopathic medications in the treatment of epilepsy with the mechanism of actions with fewer side effects in comparison to allopathic medications that cause side effects which may be dangerous in some situations so to overcome these problem Ayurveda and homeopathy plays a major role. The new advancement in the management and cure of epilepsy with the help of several newly discovered compounds that are more advanced than the marketed drugs which are under clinical trials and have fewer side-effects than existing drugs and in coming years these compounds will be part of epileptic drugs. Development of the animal epilepsy model with the help of AI techniques to reduce the failure of the model, AI is a useful tool in drug discovery and can evaluate vast data easily and is a time-consuming...
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Posted by admin on May 31, 2024 in |
Background: Chronic kidney disease (CKD) is defined as either kidney damage or a decreased glomerular filtration rate (GFR) of less than 60 mL/min/1.73m2 for 3 or more months. The prevalence of CKD in India is 17.2% and it is substantially higher in hypertension, Diabetes, and vascular disease patients. Polypharmacy potentiates the risk of medication-related problems, such as drug-drug interactions and complex drug. Objective: To assess the pattern of prescription and drug interactions in chronic kidney disease patients. Methodology: It was a cross-sectional study done from November 2022 to April 2023. The study was conducted on 60 in patients diagnosed with CKD in the Department of General Medicine in Victoria Hospital attached to BMCRI. The pattern of prescription was assessed in addition drug interactions were assessed by using Medscape – an online drug interactions checker. Results: The data demonstrated that most of the patients who were diagnosed with CKD were males (60%) and in the age group of less than 60 years (88%). 50% of patients belong to CKD stage...
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Posted by admin on Apr 30, 2024 in |
Lacosamide is an antiepileptic bitter drug used to treat partial onset seizure. The aim of the work was to mask the taste of lacosamide and then formulation and evaluation of tablet. Taste was masked using spray dryer. Oral disintegrating tablet was prepared using 3 superdisintegrants Sodium starch glycolate, Crosscarmellose sodium and Polyplasdone XL10. Out of these polyplasdone showed quick disintegration. The 32 factorial experimental design was applied to optimize response variable disintegration time and drug release. Tablet from optimized batch (F9) disintegrate within 27 seconds with 99.38% drug...
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Posted by admin on Apr 30, 2024 in |
Periumbilical perforating pseudoxanthoma elasticum (PPPXE) presents as well-defined, yellowish, atrophic plaques encircling keratotic papules, often observed in obese, multiparous women. This dermatosis is considered either a localized acquired cutaneous disorder or a variant of hereditary pseudoxanthoma elasticum. We report a case clinically diagnosed with differentials but confirmed as PPPXE through histopathological examination. The patient, a middle-aged woman, presented with characteristic lesions in the periumbilical region, prompting consideration of various differential diagnoses. However, microscopic analysis revealed the distinctive features of perforating pseudoxanthoma elasticum, including the presence of transepidermal elimination channels and abnormal elastic fibers. This case underscores the importance of histopathological evaluation in confirming the diagnosis of PPPXE, especially when clinical presentation overlaps with other cutaneous conditions. Awareness of this entity is crucial for accurate diagnosis and appropriate management, given its potential implications for systemic health. Further research is warranted to elucidate the pathogenesis and optimal treatment strategies for PPPXE. Our case contributes to the expanding literature on this rare dermatosis, emphasizing the significance of a multidisciplinary approach involving dermatologists...
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Posted by admin on Apr 30, 2024 in |
This review explores the multifaceted roles of Src kinases, a subfamily of non-receptor tyrosine kinases, shedding light on their involvement in diverse diseases. Src-family protein tyrosine kinases (SFKs) exhibit widespread expression across various cell types, influencing their behavior and functionality. Src’s presence in distinct subcellular locations, such as plasma membranes, perinuclear membranes, and endosomal membranes, underscores its versatility and potential impact on cellular processes. Research indicates a significant association between SFKs and various disorders, emphasizing their relevance as potential therapeutic targets. The intricate interplay of SFKs in cellular membranes suggests a nuanced role in disease pathogenesis. The comprehensive examination of Src kinase’s involvement in different cellular contexts contributes to a better understanding of its potential implications in disease development. In conclusion, this study underscores the pivotal role of Src kinase and positions it as a promising therapeutic target for addressing a spectrum of illnesses. By elucidating the intricate mechanisms through which SFKs operate in cellular membranes, this review advocates for further exploration of Src kinases as crucial players in...
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