Posted by admin on Jan 31, 2024 in |
Antidyslipidemic activity of extract of Eugenia jambolana (EJ, Jamun fruit) in adult Charles Foster rats of both sexes was studied and compared with that of Atorvastatin (Atorva). 4 groups were made [Gp 1- Control group (no drug), only high fat diet (HFD); Gp 2- HFD +EJ (evaluation of role of EJ in the prevention of dyslipidemia); Gps 3 & 4-only HFD]. This was the phase of disease production, lasting for 7 weeks, in which we also evaluated the preventive role of EJ. Thereafter, therapy phase started, which lasted for 90 days [Gp 1-Control group (no drug). Only HFD; Gp 3- HFD+ Atorva; Gp 4- HFD+EJ]. Parameters tested were TC (total cholesterol), TG (triglycerides), LDL (low density lipoproteins) and HDL (high density lipoproteins). During the prevention/ disease production phase, EJ brought an improvement in TC level as compared to control group, which was statistically not significant; but improvements in TG, LDL & HDL levels were significant. Moreover, in the therapy phase, EJ brought significant improvement in all the parameters. It...
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Posted by admin on Jan 31, 2024 in |
The healing homes of plant life have been identified because time was immemorial. Many pathological conditions have been handled using plant-derived drug treatments. Recent advances in analytical and computational strategies have opened new avenues to technique complex natural merchandise and to use their structures to derive new and revolutionary drugs. Indeed, we’re in the era of omics as applied to herbal products. Predictive computational software programs have contributed to the invention of molecular targets for natural products. The rapid adoption of omics procedures to research facts using genomics, transcriptomics, proteomics, and metabolomics has opened a new manner toward natural drug discovery. The records of omics, the technology utilized in omics gear, role of omics in natural drug discovery, its strengths and challenges of omics equipment are discussed in this...
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Posted by admin on Jan 31, 2024 in |
In this study, the preventive and protective potentials of Murray koenigii (MK) leaves and Momordica charantia (MC) fruit extracts against experimentally induced peptic ulcers in Wistar rats were evaluated. Rats were divided into six experimental groups – normal (saline), control (ulcers), pretreatment with MC extract (fresh fruit juice, 500ml/kg), MK extract (400mg/kg)or both, and pretreatment with standard drug ranitidine (RTD). Parameters assessed in the study were -ulcer score, ulcer index, free acidity, total acidity, percentage of ulcer inhibition, pH of gastric juice, gastric volume, C-reactive protein, macroscopic evaluation of the stomach, and histopathological studies. The results of the pharmacological studies on the co-administration of MK extract and MC juice showed a significant decrease in ulcer score, ulcer index, gastric volume, free acidity, total acidity, and CRP value when compared to positive control. The pH and percentage of ulcer protection were significantly increased in the co-administration extracts treatment group comparably with the standard ranitidine group. Hence, the study revealed that pre-treatment with the combined administration of Murraya koenigii leaves and...
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Posted by admin on Jan 31, 2024 in |
Objective: The main purpose of this current work is to optimize the formulation and in vitro evaluation of gabapentin niosomes. Methods: Niosomes are formulated by utilizing the thin film method. Gabapentin niosomes are prepared with cholesterol and span 80. Pre-formulation and post-formulation studies were carried out for optimized gabapentin niosomes. Such as FTIR, DSC, Zeta, Particle size, TEM, SEM, and in-vitro drug release studies. Report: Gabapentin medication pre-formulation experiments were carried out. The ultraviolet spectroscopic maximum of gabapentin was found to be 206nm. Within the concentration range of 2-10 g/ml of drug in phosphate buffer 7.4 solutions; gabapentin follows Beers law with a slope of 0.1086 x and an R2 value of 0.9985. The particle size was determined to be round and spherical in the improved formulation F7. The particle sizes are in the 50-120mm range. Particle’s external morphology/outer surface morphology were determined. Conclusion: The goal of this study was to optimize the formulation and in-vitro evaluation of gabapentin niosomes for epilepsy treatment. As a result, the current research...
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Posted by admin on Jan 31, 2024 in |
The solubility problem of drugs is always one of the most challenging aspects in formulation and development of dosage forms. In fact, most of new chemical entities are poorly water soluble and not well-absorbed after oral administration resulting in low bioavailability. The current challenges of the pharmaceutical industries are related to techniques that improve the water solubility of drugs. Solid dispersions are one of the most successful strategies to enhance the oral bioavailability of poorly water-soluble drugs by reducing particle size and improving drug wettability. This article reviews various types of solid dispersion, and their preparation techniques. Some of the practical aspects to be considered for the preparation of solid dispersions are selection of carrier and methods of physicochemical characterization thorough study of nature of drug in solid dispersion etc. are discussed. At the end of the article commercialization of some solid dispersion and recent revival has been considered. This article gives scope for research in enhancement of solubility of poorly water-soluble...
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