Posted by admin on Feb 28, 2017 in |
Flavonoids are natural products widely distributed in plant kingdom that gained lot of importance due to variety of biological effects relevance to numerous healthcare. It has been chosen as a drug molecule and gained attention in the area of novel drug delivery system because of their disease preventing property and therapeutic expediency in multiple biological effects. Chrysin (C) is one of the most utilized flavonoid having pharmacological effects such as anti-oxidant, anti-inflammatory, anti-cancer, antidiabetic and anti hypertensive actions. Even though it has potential therapeutic value and beneficial effects on human health, it possesses some disadvantages like poor solubility and low bio-availability, this limits its therapeutic usage of Chrysin. The present work designed to improve the solubility and the bioavailability of chrysin by the developing a chrysin loaded chitosan nanoparticles (NC). It was prepared by ionic gelation of chitosan and tripolyphosphate. The chrysin loaded chitosan nanoparticles were prepared in 5 batches and named as NC1, NC2, NC3, NC4 and NC5. The formulated nanoparticles were characterized by particle size analyzer, Zeta...
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Posted by admin on Feb 28, 2017 in |
Adiponectin has been schown to protect from insulin resistance, demonstrate anti-inflammatory and anti-atherosclerotic effects and be involved in the pathogenesis of metabolic syndrome (MS). We aimed to assess the association between serum adiponectin concentration, insulin resistance and various risk factors of MS and to investigate the relationship between the single nucleotide polymorphism (SNP) +45 T>G ( rs 2241766) in the adiponectin (ADIPOQ) gene and the risk of MS. 200 patients with MS and 250 healthy controls were enrolled in this study. The level of fasting serum insulin, glucose, and lipid levels were measured. Insulin resistance was estimated using homeostasis model of assessment for insulin resistance (HOMA-IR). Serum adiponectin levels were measured by enzyme-linked immunosorbent assay and the SNP +45 T>G in the ADIPOQ gene was performed by the polymerase chain reaction-restriction fragment length polymorphism method. MS patients had a significantly higher levels of HOMA-IR (p<0.001) and lower serum adiponectin concentrations (p<0.001) compared to controls. Multiple regression analysis showed that serum adiponectin levels was associated negatively with HOMA-IR (r=-0.307; p=0.001)...
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Posted by admin on Feb 28, 2017 in |
There is no doubt that quite a number of obstacles are stumbling blocks to students’ practical skill acquisition. Such impediments could either be as a result of factors directly related to students, their lecturers or the institutions where the students are undergoing their training. This study identified the hindrances to practical skill development among the students in Kaduna Polytechnic, Nigeria. Four research questions and a null-hypothesis guided the study. 840 Academic staff and 18000 students of the polytechnic form the population, out of which proportionate stratified random sampling technique was used to draw a sample of I68 lecturers and 900 students for the study. A 52-item questionnaire was used to collect data from the respondents, while mean statistics and z-test were used for data analysis and testing of hypothesis respectively. The study revealed that there is no significant difference in the mean response of lecturers and student on obstacles to practical skill development among the students in Kaduna Polytechnic. The major findings include students’ lack of sound technical background,...
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Posted by admin on Feb 28, 2017 in |
Objective: The present study was designed to evaluate the pharmacognostical and quality control parameters of Tribulus terrestris L. whole plant except fruits. Method: The plant was collected from the university campus and was got authenticated from NBPGR, Delhi. Various standardization parameters viz. loss on drying, ash values, extractives values, swelling index, foaming index etc. were determined as per the procedure laid down in Ayurvedic Pharmacopoeia of India and WHO Guidelines. Macroscopic and microscopic studies were also performed. Results: The present study provided pharmacognostical, physicochemical details, elemental analysis and microbial contamination of the plant which will help in designing the pharmacopoeial monograph. The microscopic studies established that the leaves are of dorsiventral type having single celled trichomes all over the stem and leaves. The plant extracts contained safe pesticides as revealed by the GCMS analysis. The phytochemical screening establishes the presence of alkaloids, carbohydrates, phenol, flavonoids, saponins and phytosteroids. Conclusions: The monograph of the plant can be established for pharmacognostical parameters, thereby confirming the credibility of the plant as a...
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Posted by admin on Feb 28, 2017 in |
Danio rerio is one of the best model organisms to study various kinds of disorders. Their genome is fully sequenced and they possess easily detectable developmental properties. The development of their embryo is quite rapid. This is important as the embryos are formed by external fertilization, are large and transparent. Abortifacient is a substance that induces abortion. It can be used in the form of a herbal extract or a synthetic drug. This study was conducted by treating Danio rerio embryos with a well-known plant having abortifacient activity like Foeniculum vulgare (fennel) seeds. A methanolic seed extract of Foaeniculum vulgare was prepared and subjected to the embryos at different post fertilization periods and at different concentrations. The compounds in the extract were characterized by GC-MS and docking studies were done to identify the compound showing maximum activity. The fertilized embryos were observed at regular intervals. The fertilized embryos are surrounded by an acellular envelope called chorion. Hence, the embryos that were treated with different concentrations of the plant extract...
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