Posted by admin on Jan 31, 2017 in |
Lansoprazole a proton pump inhibitor used in the short term treatment of gastric and duodenal ulcer, reflux esophagitis, structuring and erosive esophagitis. In the present investigation an attempt has been made to enhance the solubility and dissolution rate of lansprozole by formulating it as solid dispersions with KollidonVA64, Soluplus and poly ethylene glycol 6000 by solvent evaporation method. The solid dispersions were further compressed as tablets by using superdisintegrants such as croscarmellose sodium (CCS) & crospovidone (CP). Rapid release of lansoprazole from solid dispersions was observed which was influenced by the proportion of carrier concentration. Among the solid dispersions prepared the dispersion formulated using Soluplus showed rapid drug release than kollidon & PEG 6000 containing Solid dispersions and pure drug alone. The release was found to follow the first order kinetics. Solid dispersions prepared by the solvent evaporation method were further formulated into tablets with superdisintegrants such as croscarmellose sodium, crospovidone. The dissolution rate of such tablet formulations were found to release the drug at a faster rate than...
Read More
Posted by admin on Jan 31, 2017 in |
Alcohol abuse is well known to impair reproductive performances due to impaired testosterone production and testicular atrophy. Many natural nontoxic herbs were found to enhance the fertility in male. The study is done to evaluate the effect of Cycas circinalis (Cc) and Ionidium suffruticosum (Is) in improving the fertility of alcohol induced sterile male albino rats. A total of 30 healthy young male albino rats were selected. A total of 24 rats were subjected to 3gm of ethanol/kg body weight/day orally for 4 weeks for experimental rats. Cc and Is extract 200mg/kg body weight were administered orally to the experimental albino rats E-I (n=6) and E-II (n=6) respectively and compared to the positive control albino rats PC (n=6) which was administered testosterone 10µg/kg body weight subcutaneously, biweekly with that of the alcohol induced sterile control rats SC (n=6) using various parameters such as sexual behavior, weight of animals, dimension and weight of testes, hormone, semen, and histological analysis. Restitution of fertility was compared with the normal fertile controls rats...
Read More
Posted by admin on Jan 31, 2017 in |
Thalassemia is among the most common genetic disorders worldwide. It constitutes a major public health problem in the United Arab Emirates (UAE). The present study assessed the level of awareness regarding thalassemia among the students of RAK Medical and Health Sciences University, Ras Al Khaimah, UAE. A specially designed, pretested and validated questionnaire was distributed to the students and their responses were recorded. Out of the total 200 students, 51.5% were from pharmacy college, 29.5% were from medical college whereas 16% and 3% were from nursing and dental colleges respectively. Majority (62.5%) of respondents were female. The mean knowledge score of pharmacy students was highest 5.66 ± 2.02 out of a maximum of 7, as compared to 5.16 ± 0.81 of dental students, 4.47 ± 1.97 of medical students and 4.34 ± 2.26 of nursing students. However, mean attitude score of dental students was the highest 3.83 ± 0.40 out of a maximum of 4, but was not much different when compared to 3.64 ± 0.66 of medical students...
Read More
Posted by admin on Jan 31, 2017 in |
Objective: 3-Substituted Schiff bases of Quinazolne-2,4-diones belongs to the N-containing heterocyclic compounds. The aim of the present study is to synthesis and characterization of ten novel derivatives of 3-Substituted Schiff bases of Quinazoline2,4-diones and their pharmacological study. In the current course of work the novel Schiff bases of Quinazolne-2,4-diones which are synthesized are evaluated for Anti-bacterial study. Materials and Methods: Present research synthesis work of 3-Substituted Schiff bases of Quinazoline 2,4-diones involve two step along with greener method and conventional method of synthesis. 3-Substituted Schiff bases of Quinazoline 2,4-diones have been evaluated for Anti-bacterial study by disc diffusion method. Result: The Schiff bases of quinazoline2,4-diones have been synthesized successfully as per the designed scheme of synthesis which includes Greener and conventional method. The greener method found to the more advantageous as compared to the conventional method. These compounds are characterized by various physicochemical and spectral analysis by the FT-IR spectral analysis and 1H-NMR. The Synthesized compounds possessed the antibacterial activity. Conclusion: The result of the present research study thus...
Read More
Posted by admin on Jan 31, 2017 in |
Morus indica- MI-S36 is a potential source of phytochemicals and is well explored for its medicinal properties such as antidiabetic and antioxidant activity. In the present study, Mous indica aqueous (MAq) and dechlorophyllised (MDc) extracts efficacy to protect against the carbon tetrachloride (CCl4) induced hepatotoxicity was studied in rats in comparison with standard drug Liv52. The experimental group rats were pre treated with MAq, MDc and Liv52 for 7days. Healthy control and positive control group animals were fed wth Olive oil and after 7days two doses of CCl4 was given at 12 and 36 hrs intervals to all the animal groups. After 12 hrs of CCl4 dosage animals were sacrificed and biochemical parameters analysed in the serum. The total protein, albumin, urea, creatinine, total bilirubin were within the normal level in all the groups whereas the hepatic enzymes AST, ALT and ALP activity was less in Liv52 and Morus treated groups. Total cholesterol, triglycerides, were determined. The total cholesterol and triglyceride levels in Morus treated groups were significantly (p...
Read More
