Posted by admin on Jan 31, 2017 in |
The study involved both aqueous extraction and methanolic extraction of the powered leaves, which ensure all plant components are extracted for better results. Phytochemical analysis from the extracts was performed using the standard protocols. The antimicrobial susceptibility of the extracts was tested against E-coli, Pseudomonas and Klebsilla sp using agar disc diffusion method. Antioxidant property of the plant was evaluated using DPPH Method and Hydrogen Peroxide Scavenging activity method whereas antidiabetic property was evaluated using α-amylase inhibition assay. The plant extracts were used at varying concentrations to ensure which plant extract and concentration causes the most inhibition. Phytochemical analysis of the extract indicated the present of Saponin, phenol , phytosterol, steroid, terpenoid, flavanoid, carbohydrates and proteins while tannin, glycoside, plobatanin were absent. Anti-diabetic property of the plant was observed with a significant result of inhibiting a maximum of 83% of α-amylase activity (700µg/ml concentration of methanol extract) whereas antioxidant property with a maximum of 85% of (200µg/ml concentration of water extract) inhibition. Antimicrobial property of the extract shows effectiveness...
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Posted by admin on Jan 31, 2017 in |
The aim of the present study was to prepare and evaluate floating microspheres consisting of (i) calcium silicate (CS) as porous carrier; (ii) famotidine and (iii) hydroxypropyl methylcellulose (HPMC) and ethylcellulose (EC) as polymers. The floating microspheres were evaluated for particle size, micromeritic properties, percent drug content, in vitro floating behavior, and in vitro drug release. The % yield of formulations (FM1 to FM9) was found to be in the range of 79.51 ± 3.71 to 93.48 ± 0.94 %. Percentage drug content of floating microspheres formulations (FM1 to FM9) was found in the range of 77.25 ± 0.36 to 86.14 ± 2.04 %. In Vitro Buoyancy percentage of the microspheres was found to be 97.5 ± 1.53 %. At pH 1.2, the best formulation FM4 showed maximum drug release (99.26 ± 1.14 %) at the end of 12 hr. The SEM photographs of formulation FM4 showed that the fabricated microspheres were spherical with a smooth surface and exhibited a range of sizes within each batch. The in vivo...
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Posted by admin on Jan 31, 2017 in |
The aim of this study was to analyze the chemical composition of dried clove buds volatile oil in Bangladesh by Gas Chromatography-Mass Spectrometry (GC-MS) technique and also show their medicinal properties according to the characteristics of the constituents present in that essential oil. In this experiment the clove buds essential oil was extracted by hydro distillation method. The major constituents obtained from the oil includes 3-Allyl-6-methoxyphenol i.e. m-Eugenol (69.44%), Eugenol acetate (10.79%), 4-hydroxy-4-mehtylpentan-2-one i.e. Tyranton (7.78%) Caryophyllene (6.80%), 1,4,7-Cycloundecatriene, 1,5,9,9-tetramethyl-,Z,Z,Z-and trace amounts (<1%) of other constituents. Eugenol is present in concentration of 69.43% which is the major volatile constituent of clove bud essential oil. It has wide range of medicinal value such as antiseptic and anaesthetic analgesic, antioxidant, anti-inflamatory and antimicrobial activities. Clove oil is used in dental care and it can relieve toothache temporarily. So, from these chemical constituents it is clear that clove buds essential oil of Bangladesh has medicinal properties because of the medicinal characteristics of these...
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Posted by admin on Jan 31, 2017 in |
The aim of the present work was to develop a new microbeads system for colon-targeted delivery of celecoxib. The ternary system were develop using PVP (polyvinylpyrrolidone) and hydroxypropyl-β-cyclodextrin (HPB) to increase solubility of celecoxib. DSC and XRD results confirmed formation of amorphous celecoxib complex with HPB. Chitosan and pectin were used for the development of microbeads of new amorphous celecoxib. Calcium chloride was use as cross linking agent for electrolyte complexation between polymers. Eudragit RS100 was used to embed into microbeads in order to avoid premature delivery of a drug in acidic environment of stomach. Statistical design of experiment was employed to investigate the combined effect of three formulation variables, i.e., % of chitosan, pectin, and CaCl2, on responses like drug release pattern in acidic dissolution medium (CDR in UGIT), colonic dissolution medium with fungus culture of Aspergillus niger (CDR in LGIT) and drug entrapment efficiency (EE%). Response surface methodology was used to analyze multivariate approach for understanding the multifactorial relationships among formulation parameters. Full central composite design was...
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Posted by admin on Jan 31, 2017 in |
Rheumatoid arthritis is an immune mediated inflammatory disease (IMID). Rheumatoid arthritis occurs when our immune system attacks the tissues near joints, this is due to release of certain chemicals and enzymes that begin to eat away the cartilage and bones. Rheumatoid arthritis affects all the joints in the body, some forms of arthritis can also affect the body’s internal organs. The symptoms of Rheumatoid arthritis include inflammation, pain, swelling and stiffness of the joints, it can also lead to deformity and disability of the joint in severe cases. There are several causes for Rheumatoid arthritis these causes are unknown but some include genetic factor, family history, age, environmental factors, hormones, smoking etc. This paper gives an overview of the medicinal plants with phytoconstituents which can be used in the treatment of RA and different treatments available for Rheumatoid arthritis. These medicinal plants can be extracted and phytoconstituents can be isolated, pharmacological studies can be carried out and the plants can be further explored for future studies. Even modern drugs used...
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