Posted by admin on Jan 31, 2017 in |
Kaempferia galanga has profound implications in the treatment of nematocide, larvicide, abdominal discomfort, cholera, various inflammatory diseases and many more. It is a potential candidate in terms of evaluating its medicinal activities. Therefore, the present study was conducted to evaluate anthelmintic and insecticidal activities of different extracts of the rhizome of Kaempferia galanga. For anthelmintic activity, Pheretima posthuma was selected as test animal while 25, 50, 100 mg/ml concentrations of samples were tested in the bioassay, from which time of paralysis and time of death of worms were estimated. Evaluation of insecticidal activity was performed against Sitophilus oryzae to calculate the mortality rate. In anthelmintic study, extracts exhibited its activity in dose-dependent manner showing higher the concentration, higher the effect. Extracts of ACR, PEF, CHF and MEF in case of 100 mg/ml concentration exhibited its paralytic effect followed by death within a short period of time among which ACR extract gave the best result which only took approx. 20 mins to show paralytic effect and 35 min for death...
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Posted by admin on Jan 31, 2017 in |
In the present study 17 novel benzaldehyde thiosemicarbazone derivatives were synthesised using 2-methyl-3-thiosemicarbazide as the main reactant and different aromatic aldehydes. Reactions were monitored using thin layer chromatography technique and the newly synthesised derivatives were characterized by Elemental analysis, ATR and 1HNMR techniques. For antibacterial activity four bacterial strains were selected namely Bacillus subtilis (gram +ve), Staphylococcus aureus (gram +ve), Escherichia coli (gram –ve), and Pseudomonas aeruginosa (gram -ve).Candida albicans was used to ascertain the antifungal activity of compounds. Antimicrobial assay was performed using nutrient agar media for the bacterial strains and Sabouraud agar for the fungus, zone of inhibition of all the compounds which could inhibit visible growth after incubation were calculated. Four different dilutions of the test compounds were taken and compared against ciprofloxacin and fluconazole as the standard drugs. Antimicrobial assay was performed in duplicate. The test compounds were active against both gram negative as well as gram positive bacteria. Considerable anti-fungal was shown by the compounds. Antioxidant assay was performed using 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulphonic acid) or ABTS...
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Posted by admin on Jan 31, 2017 in |
1,2,3-Benzotriazole (BTA) is a heterocyclic compound with three nitrogen atoms. The enormous investigations on derivatives of benzotriazole reveals wide applicability of this molecules for tagging and delivering huge number of heterocyclic nuclei. This molecule has been used for the analytical determination of silver as well as a restrainer in photographic emulsions. The effectiveness of 1,2,3-Benzotriazole (BTA) as drug precursors have been drawing attention for a long period. The derivatives of benzotriazole act as agonists for many biologically active proteins. For instance, corozole and alizapride have the inhibitory properties against different proteins and Benzotriazole esters have been reported to work as mechanism-based inactivators for severe acute respiratory syndrome (SARS) 3CL protease. The various derivatives synthesized by different research workers showed antimicrobial activities such as antibacterial, antifungal, antiviral, anthelmintics, antiprotozoal and antimycobacterial activity. The present article throws light on the different derivatives of benzotriazole and their related biological activity, and is reported chronologically. The chronologic development in the synthesis of its derivatives and related changes in therapeutic activity opens new channels...
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Posted by admin on Jan 31, 2017 in |
Recent decades have experienced a sharp increase in the incidence and prevalence of diabetes mellitus. The major therapeutic approach is to diabetes is to reduce gastrointestinal glucose production and absorption through the inhibition of carbohydrate digesting enzymes such as α-amylase and α-glucosidase. The agonists of PPAR γ is of great interest to the pharmaceutical industry since they regulate the expression of genes Associated with diseases like cancer, diabetes, atherosclerosis and obesity The aim of the current study was to synthesize newer PPAR γ agonists with alleged antidiabetic properties for α-amylase and α-glucosidase inhibitory activities. Newer PPAR γ agonist ligands containing three parts acidic head, a linker, and a hydrophobic tail as Pharmacophore features were designed. Four different compounds containing thiazole as heterocyclic nucleus have been synthesised and characterised by analytical methods like IR, NMR, spectral data. All the synthesised molecules were Optimizied using Lipinksi’s rule of five and subjected to docking studies using ARGUS LAB 4.0. Docking studies showed the important interactions of lead molecules posses with some of...
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Posted by admin on Jan 31, 2017 in |
Due to your efforts diligent on quinoline nucleus new series containing pyrimido [4, 5-b] quinoline were synthesized via starting with the strategic 2-aminoquinoline-3-carbonitrile (2) intermediates to afford various pyrimido [4, 5-b] quinoline via cyclization with different reagents to get compounds 3-24. Compounds 3, 6, 9a, 9b, 12, 15, 16a, 16b, 17, 21 and 24 were tested for in vitro antitumor activity against human breast carcinoma (MCF-7) cell line, We found what we were hoping for where compound 6 was found the most active member (IC50= 48.54 μM) than the Doxorubicin as a reference drug with (IC50= 71.80 μM). To understand the interaction of binding sites with the target protein receptor, the docking study was performed using topoisomerase II. The results of in vitro cancer activity and docking study revealed that the synthesized compounds have potential cancer activity and can be further optimized and developed as a lead...
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