Posted by admin on Dec 31, 2016 in |
Background: India is highest tuberculosis (TB) burden country accounting for approximately 20% of global TB burden. To tackle this problem, Revised National Tuberculosis Control Programme (RNTCP) based on the DOTS (Directly Observed Treatment Short course) strategy has been made available in the entire country by March 2006. Present study describes the achievements under RNTCP in terms of treatment outcomes, smear conversion rate and evaluation of risk factors for unsuccessful treatment outcome at district tuberculosis centre. Objectives: Treatment outcome of tuberculosis (TB) patients on DOTS (category 1& 2) and evaluation of predictors for unsuccessful outcome. Methodology: A record- based retrospective study; analysis of cases registered for treatment for Cat -1 & 2 at district tuberculosis centre during 2013 & 2014 was done. Data regarding demographic profile, TB type & categories, investigation, treatment outcome and co morbidity were recorded. Data were analyzed and appropriate statistical test was done using Epi info 7, CDC. Result: Out of 1340 registered cases, 1081 (80.67%) were of cat1 and 259 (19.33%) were of cat-2 TB. ...
Read More
Posted by admin on Dec 31, 2016 in |
Simultaneous estimation method for Norfloxacin and Tinidazole in tablet dosage form had been developed by RP- HPLC. Both the drugs come under the category of antimicrobials and prescribed frequently in combination. The developed method is a gradient method which gives retention time of Norfloxacin and Tinidazole as 3.8min and 4.8min respectively. The separation was carried out on Supelco C18 (25cm × 4.6mm, 5µ) column using 0.05M phosphate buffer (pH 3 adjusted with ortho- phosphoric acid) and acetonitrile as a mobile phase. The flow rate was 0.8mL/min and wavelength used was 300nm. The method was validated as per ICH guideline and found to be linear between the range of 1- 6µg/mL for Norfloxacin and 1.5- 9µg/mL for Tinidazole. The developed method was found to be rapid, accurate and reproducible and therefore can be applied for simultaneous estimation of both the drugs as API or tablet dosage form...
Read More
Posted by admin on Dec 31, 2016 in |
Essential oils extracted from two Algerian endemic plants Lavandula antineae and Thymus algeriensis were analyzed by the GC, the results showed the presence of a large amount of oxygenated sesquiterpenes in both species. Total phenolics and flavonoids content were determined according to the Folin-Ciocalteu method and the aluminum trichloride method, the antioxidant activities of two types of extracts (ethyl acetate and n-butanol) from the plants were tested with the 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical. The rates of total phenolics and flavonoids present in L. antineae equal to 2,013± 0,009 mg GAE / g of dry plant and 0.587± 0,003 mg QER / g of dry plant material respectively. Thymus algeriensis has presented values of phenolics and flavonoids equal to1.337± 0,001 mg GAE / g and 0.339± 0,001 mg QER / g of the dry plant. The ethyl acetate extract of L. antineae have presented the higher EC50 value...
Read More
Posted by admin on Dec 31, 2016 in |
“Acid labile drug” means a drug that is easily destroyed in acidic environment, Stomach is the main site for drug absorption mainly by oral rout. The pH of the stomach is acidic so the absorption of acid labile drugs through stomach is difficult. For this resign the drugs should be formulated as enteric coated or may be administered through parenteral rout. These approaches are effective but they increase the cost of the dosage form. So for making the acid labile drug effective in acidic environment one of the best approach is in-situ buffer formulation. These are the formulation containg agents which immediately buffer the internal environment of the body and increases the stability of acid labile drugs inside the body. This article covers the possible approaches for buffer formulation, formulations could be possible, method of preparation and evaluation of in-situ buffer formulation. The articles the examples of agents can be used as...
Read More
Posted by admin on Dec 31, 2016 in |
Sunscreens aid the body’s natural defense mechanisms to protect against harmful UV radiation from the sun. The present study involves the formulation of sunscreen cream with herbal active ingredients and evaluation for its effectiveness. Naturally occurring traditional substances are gradually replacing synthetic counterparts due to their effectiveness and absence of adverse effects. The herbal drugs selected for the study were roots of Glycyrrhiza glabra Linn. (Yashtimadhu), Hemidesmus indicus R.Br. (Anantmul) and heartwood of Santalum album Linn. (Chandana). Creams were prepared with each individual herb and combination of all three herbs with varying concentration of herbal extracts. The evaluation included determination of Sun Protection Factor for all the formulated creams. The SPF was calculated using the spectrophotometric method and then applying the Mansur equation. The results of the study indicated that the 25% combination cream showed maximum sun screeening...
Read More
