Posted by admin on Oct 31, 2017 in |
The present study on Embilica officinalis, a common household remedy and the present study describes the inhibition of enzyme xanthine oxidase (XO) with in vitro analyses and assenting in silico study to produce an effective phytoconstituents. The results explained the ethanolic extract of Embilica officinalis (EOEt) exhibited antioxidant and defensive oxidative stress and allied with its total phenol (51.33 ± 0.793 mg/g) and flavonoid content (33.51 ± 0.616 mg/g). Additionally, the DPPH scavenging activity shows significant correlation between antioxidant and XO inhibitory activities result in IC50 value of 40.40 ± 0.1475µg/ml. The EOEt extract probably inhibited the nitric oxide formation with increase in concentration with IC50 of 28.36 ± 0.1522µg/ml. The EOEt extract shows increase in dose dependent manner in percentage of XO inhibitory activity and exhibits potential IC50 value (352.0 ± 0.2069 µg/ml) compared to standard allopurinol (723.9 ± 0.2081µg/ml). The in silico docking studies of the major phytoconstituents (Phyllembilic acid B, Ethyl gallate, Gallic acid, 5-Hydroxymethylfurfural, Ascorbic acid, 1, 2, 3-benzenetriol, Ethyl alpha-d ̶ glucopyranoside and β...
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Posted by admin on Oct 31, 2017 in |
Naproxen, a non-steroidal anti-inflammatory drug suggested for the long term treatment of disease conditions such as Rheumatoid Arthritis and Osteoarthritis poses an immediate risk of stomach ulceration. To avoid this risk, a proton pump inhibitor is often prescribed along with it. In the present study, Naproxen (500mg) is prepared in combination with Pantoprazole, a proton pump inhibitor as a multi-layer coated tablet. First, Naproxen is prepared as core tablet by wet granulation method. Then it is enteric coated to assist its delayed-release. Over this enteric coated tablet, Pantoprazole (20mg) drug layer is applied to get combination product. The prepared tablets were evaluated for physicochemical properties such as weight variation, hardness, friability, disintegration and drug content. The in-vitro drug release studies were conducted for Naproxen core tablets, Naproxen enteric coated tablets and multi-layered tablets in 0.1N HCl and 7.4 pH phosphate buffer. The analytical results obtained at several stages of preparation of the product were found to be satisfactory. The in-vitro drug release studies of Naproxen and Pantoprazole from multilayered...
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Posted by admin on Oct 31, 2017 in |
Stress is one of the most significant health problem in modern society. This paves way for the researchers to focus and investigate into the biological pathways linking stress and health. Hence the goal of the present study is to discover novel drug derivatives from the active principle α asarone of the plant Acorus calamus Linn. (ACL) which was found to have antioxidant &antidepressor effect the basic physiological response to stress is through activation of Corticotrophin –releasing factor Receptor 1 (CRFR-1) which is predominantly found in pituitary gland is mainly responsible for signalling the adrenal gland receptor thereby increasing the Glucocorticoids as a response to stress. The 3D structure of CRFR 1 was derived from RCSB-PDB database and the α asarone was derive from Pubchem database. A total of 100 ligands were derived from α asarone using in silico method by ACD chemsketch software. Rapid virtual screening of these compounds were performed in the dock in tool iGEMDOCK v2.0. Based on the binding energy a total of seven ligands were...
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Posted by admin on Oct 31, 2017 in |
Indian medicinal plants and traditional knowledge have been an integral part of our lifestyle since ages and now became an important source for natural product research (NPR) and development. Due to its knowing ability and applications, this knowledge has long been used as a thriving source for discovery of new drug molecules. This study was conducted under the routine drug development program of the Institute with the aim to explore the first-hand ethnobotanical information of 4 important plants i.e. Artemisia nilagirica, Lyonia ovalifolia, Sarcococca saligna and Taraxacum officinale and to correlate their possible applications in future research and developmental activities. The reported information was collected from 86 informants (villagers and herbal practitioners) of Nainital, Almora and Bageshwar districts of Uttarakhand Himalaya, during 2014-2016. The popularity of individual plant species for their ethnopharmacological uses was calculated as percent citation (PC) and cross verified through other informants of studied areas as well as the literature reported for their modern therapeutic...
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Posted by admin on Oct 31, 2017 in |
The appreciation of appearance is increasingly widespread in the media and involves a smile-related beauty standard. Any change in teeth compromises the appearance and may reflect on the psychological and social behaviour of the human being. Consequently, there has been technological advance in aesthetic and technical restorative materials, such as dental bleaching, as well as the development of more effective drug delivery techniques, such as micro-emulsions and liquid crystals. In this work, dispersed systems containing hydrogen peroxide were developed, characterized and evaluated for dental bleaching agents, with permeation potential in the dentinal tubules in order to optimize the bleaching process. Two pseudo-ternary diagrams were developed. Two formulations of the second diagram were selected and characterized (optical microscopy, pH, particle size, polydispersity index, zeta potential), and then, preliminary and accelerated stability study. In these formulations, the hydrogen peroxide was incorporated in concentrations 6 and 14%. The photomicrographs of the formulations revealed dark field, characteristic of the cubic phases. The product containing 6% hydrogen peroxide obtained pH values of 6.06 ±...
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