Posted by admin on Nov 30, 2017 in |
Epilepsy is a neurological disorder which often requires lifelong treatment with antiepileptic drugs (AEDs). Prolonged use of AEDs is associated with changes in vascular risk markers. Hence, the study was designed to evaluate the effect of older generation AEDs (carbamazepine and phenytoin) and newer generation AED (levetiracetam) monotherapy on the markers of vascular risk in epilepsy patients. This study was carried out in the neurology department of a tertiary care hospital for a period of 7 months. Clinical and biochemistry reports of 90 patients were collected in designed case report forms. All statistical analyses were performed using IBM Statistical Package for Social Sciences (SPSS) 17 and Graph Pad Prism 7.0. We observed statistically significant changes in the lipid profile and C-reactive protein (CRP) in carbamazepine and phenytoin received groups. We did not observe any statistically significant difference in the above parameters in levetiracetam group. Thus, careful monitoring of the serum lipid profile and CRP at regular intervals throughout the treatment course is considered necessary in epileptic patients undergoing long-term...
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Posted by admin on Nov 30, 2017 in |
Arcuate nucleus GABAergic system plays an important role in the energy balance evidenced by various studies. The present study was designed to investigate the involvement of GABA type A receptor in experimental obesity. In the present study effects of chronic administration of diazepam (0.5 and 1mg/kg/day, i.p) and bicuculline (0.6 and 1.25mg/kg/day, i.p) specific GABA type A receptor agonist and antagonist respectively for 8 weeks along with high fat diet to the obese rats which were pre-treated with high fat diet feeding for 8 weeks on the various parameters of obesity were analysed. Treatment with bicuculline (0.6 and 1.25mg/kg/day, i.p) produced significant dose dependent decrease (p < 0.05) in various parameters of obesity as compared to high fat diet group. Diazepam (0.5 and 1mg/kg/day, i.p) produced dose dependent increase in the feeding behaviour in experimental obese rats, while the other parameters were not significantly altered with chronic administration of diazepam as compared to high fat diet control group. Diazepam a negatively alter the parameters of obesity, while the bicuculline...
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Posted by admin on Nov 30, 2017 in |
Background: Antimicrobial resistance against S.aureus infections is a global public health problem resulting in very limited treatment options, and inappropriate use of antibiotics is one of the most important factors that could affect the increasing pattern of resistance. Objective: To determine the antimicrobial resistance pattern of S. aureus among healthy and adult students to commonly used antimicrobial agents. Materials and Methods: This study was carried out at Cytogene Research and Development laboratory, Indira Nagar, Lucknow, India. Samples from throat were collected as throat-swab which were cultured and screened for S. aureus using standard microbiological protocols. The antimicrobial susceptibility of identified S. aureus was evaluated using disc diffusion technique. Results: A total of 47(54%) S. aureus were identified from 87growths of the 185throat swab samples. All the S. aureus isolates were methicillin resistant; they exhibited total resistance to penicillin, 100% to Erythromycin, 97.8%to Amoxicillin, 91.4% to Clindamycin, 78.7% to Vancomycin, 53.1% to Gentamicin, 44.6% to Trimethoprime, 19.1% to Tetracycline and 6.3% to Ciprofloxacin. Conclusion: The resistance to antibiotics agents is...
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Posted by admin on Nov 30, 2017 in |
The present work deals with formulation of topical gels containing aqueous extract of P. acerifolium seeds and also to evaluate the prepared gels against some Gram-positive and Gram-negative bacteria. The antibacterial activity of various P. acerifolium seed extracts was measured through determining minimum inhibitory concentration (MIC) by cube dilution method and zone of inhibition by disc diffusion method against E. coli, P. aeruginosa and S. aureus. Aqueous P. acerifolium seed extracts exhibited comparatively higher antibacterial potential in comparison with that of other extracts and employed to formulate topical herbal gels using 4.5 % sodium carboxymethyl cellulose as gel base. Prepared herbal gels were tested for pH, viscosity, extrudability and spreadability. All the prepared gels were subjected to antibacterial study by determining zone of inhibition by disc diffusion method. Herbal gels containing 15 % aqueous P. acerifolium seed extract exhibited better zones of inhibition against E. coli, P. aeruginosa and S. aureus in comparison with that of 5 % and 10 %. From the results of this study, it can...
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Posted by admin on Nov 30, 2017 in |
The objectives of the present study were to evaluate the preliminary phytochemical analysis (quantitative and qualitative) and DPPH antioxidant activity of two traditionally important plants occurring at Purulia district of West Bengal in India. Qualitative analysis of phytochemicals (flavonoid, alkaloid, terpenoids, saponins, phenol and carbohydrate) and quantitative analysis of total phenolics and flavonoids were done by using suitable test protocols available in the literature. Antioxidant activity was studied through DPPH assay. Qualitative phytotochemical analysis revealed that the methanolic extract exhibit richness in flavonoids, alkaloids, terpenoids, saponins, phenols and carbohydrates in comparison with aqueous extract. Total phenol and flavonoid content shows highest concentration in methanolic part of A. aspera (1.129mg GA EQ/gm, 3.22mg QEQ/gm) and lowest concentration in aqueous part of S cordifolia (.348mg GA EQ/gm, .324mg QEQ/gm). EC50 values of the two plants were 48.06µg/ml in A. aspera and 52.43µg/ml in S. cordifolia. The results conclude that there is positive correlation between total phenol content and DPPH antioxidant activity. The plants could serve as potential source of natural...
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