Posted by admin on May 31, 2017 in |
In the present study, an attempt was made to design and evaluate mucoadhesive bilayer tablet of losartan potassium (angiotensin II receptor antagonist), in order to overcome bioavailability problems, to reduce dose dependent side effects and frequency of administration. The losartan potassium mucoadhesive buccal tablet were prepared by wet granulation method using chitosan as a mucoadhesive polymer to prolong the drug release and to avoid first pass metabolism. The prepared Mucoadhesive buccal tablets were evaluated by pre and post compression parameter. Precompression test like bulk density, tap density, angle of repose and post compression test include thickness, hardness, friability, weight variation, drug content, disintegration time, wetting time, surface pH, in-vitro drug release and ex-vivo mucoadhesive time. The drug excipients compatability was evaluated by DSC...
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Posted by admin on May 31, 2017 in |
Cholesterol is a waxy substance which is made in the body by the liver but is also found in some foods. It plays a vital role in how every cell works and is also needed to make Vitamin D, some hormones and bile for digestion. The concept of energy of a graph was introduced by I. Gutman in the year 1978. In this paper, we compute Siedel Energy, Maximum Degree Energy, Distance Energy, Harary Energy of...
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Posted by admin on May 31, 2017 in |
Annona squamosa Linn.commonly called as custard apple, is an edible tropical fruit belongs to the family Annonaceae, is said to show varied medicinal effects, including insecticide, antiovulatory and abortifacient. Hence the present investigation was carried out to determine the phytochemical composition of A. squamosa leaf extract using Gas Chromatography–Mass Spectrometry technique, while the mass spectra of the compounds found in the extract was matched with the National Institute of Standards and Technology (NIST) library. This paper shows the isolation and structural elucidation of the several new natural bioactive compounds from the leaf of A. Squamosa linn in hydroethanolic extract. GC-MS analysis expressed thirty analytes, among that two compounds were showed high peak level such as of 2-Butanone, 3-amino-4-phenyl-(10.21%) and (-)-1,2,3,4-Tetrahydroisoquinoline, 6,7-dimethoxy-2-methyl-1-(6.01%), Hence, the present study focused the leaf extract of Annona squamosa plant possessed promising source of bioactivity as well as justifying the use of this plant to treat many ailments in folk and herbal...
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Posted by admin on May 31, 2017 in |
Stannous chloride (SnCl2), an inorganic salt and Dimethyltin dichloride (DMTC), the organic species were found to influence the survival and nitrogen assimilatory system of Nostoc muscorum. A difference in the survival fractions suggested for differential susceptibility of the strain to the toxic effects of the either tin species. Growth of the Nostoc muscorum cells, measured as a function of graded concentration of SnCl2 and DMTC, both in the absence and presence of exogenous nitrogen sources, revealed an increased tolerance of Nostoc cells in the presence of nitrite (NaNO2), next to nitrogen-fixing condition. DMTC induced decline in the Nitrate Reductase (NR) and stimulation in the Glutamine synthetase (GS) activity indicated nitrogen starvation like condition. On the other hand, a vice versa result obtained with SnCl2 suggested for toxic effect of the inorganic nitrogen...
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Posted by admin on May 31, 2017 in |
Background: Immunization is the most cost-effective intervention for infectious diseases which are the major cause of morbidity and mortality worldwide. There is a scarcity of information on the vaccination status of young adults and the role of socioeconomic conditions in India. Objectives: Present study explored the adult vaccination status and influence of income and education of parents on adult vaccination status in university students from Mumbai, India. Methods: On the basis of the eligibility criterion 149 students were selected for the present study. A total of 8 vaccines namely Tdap/DTP, Varicella, MMR, Influenza, Pneumococcal, Hepatitis A, Hepatitis B and Meningococcal were included in this study for all the respondents. In addition to these vaccines, Human Papilloma Virus vaccine was also included for female respondents. Results: There were total of 149 (75 male and 74 females) respondents with the mean age of 21.5 years. The top 3 immunizations were Td/Tdap (97.3%), MMR (66.4%) and Hepatitis B (55%) among the respondents. Only 4 (5.5%) female respondents have been immunized against the...
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