Posted by admin on Apr 30, 2017 in |
Allergic rhinitis is a common disease of immune system that negatively affects general health, quality of life, and social relationships. In the recent years, many studies have been conducted to discover novel treatments for this disease particularly using natural products. Here, we review findings of recent studies that harness medicinal plants and phyto-therapies in oriental medicine that have effectively reduced allergic rhinitis complications. We also assess the use of medicinal plants and their derivatives in oriental medicine to treat allergic rhinitis. In addition, these agents have been reported to be used in combination with each other or separately as complementary therapies and even, in some cases, alternative therapies instead of chemical drugs. These plants display their anti-allergy effects through affecting immunoglobulin and inhibiting different cytokines and interleukins. Medicinal plants and traditional approaches can still offer new therapeutic alternatives to researchers and pharmacists so that these alternatives may further contribute to allergic rhinitis drug...
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Posted by admin on Apr 30, 2017 in |
Purpose: To prepare and evaluate floating tablet of curcumin for prolonged gastric residence time and increased drug bioavailability for the treatment of gastric problem. Methods: Floating tablet were prepared by wet granulation method using different ratios of Curcumin, Psyllium husk, HPMC K 15 M, HPMC K 100 M and Mangifera indica gum. The respective powders were blended thoroughly and a dump mass was prepared by adding the granulating agent. Dump mass was passed through sieve number 10 and dried in hot air oven at 50 0C for 30 mins. After drying, granules were further passed through sieve number 22 to attain the uniformity in granules. Finally, optional additives like magnesium stearate and talc were added and finely blended for preparation of floating tablet. Result: Floating drug delivery tablets were being formulated and the present study focused on the formulation of FDDS by using different polymes like phyllium husk, HPMC K 100 and HPMC K15 and to evaluate its efficacy in reducing ulcers caused by H.pylori. The Floating drug delivery...
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Posted by admin on Apr 30, 2017 in |
Mucoadhesive buccal patches provide a wide variant of therapeutic effect via mucosa and buccal region of the mouth. They provide zero first pass metabolism and high bioavailability providing patient compliance. In the present study, buccal patches of paracetamol were developed to improve the bioavailability and half life of the drug. In the process of its preparation binder plays a greater role in holding the drug. One of such is Tamarind seed polysaccharide (TSP) isolated from the kernels of Tamarindus indica seeds was used as a binder in the preparation of paracetamol mucoadhesive buccal patches. Here, solvent casting method was employed and performed various evaluation parameters. Mucilage extracts at 0.5,1, 1.5, 2, 2.5% concentrations were used. All the patches were shown smooth surface and elegant texture. The weights of (10 mm) patches were in the range of 21.6 to 26.8 mg. The results indicate that the formulation with 2% mucilage extract shows maximum drug release. Among the five formulations (F1 to F5), F4 formulation showed maximum percentage of drug...
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Posted by admin on Apr 30, 2017 in |
Varicose Veins can be explained as a disorder of the veins (especially of legs) wherein they get affected due to the backward flow and turbulence in the circulation of the blood. The veins get perverted, become enlarged due to a condition called edema. The disease also shows many associated symptoms which worsens the condition of the varicose veins. The present article deals with brief introduction regarding the etiopathogenesis of varicose veins, related causes and symptoms, the current surgical and non-surgical treatments, and the study of natural drugs which may be useful in curing the varicose veins. It indicates the benefits of the natural drugs over the complicated treatments. The natural treatments may prove to be more beneficial and cost effective than the other complex treatments such as surgeries, and laser treatments. The aim of writing this review is to evaluate the role of the herbal drugs for the treatment of varicose veins and the critical analysis of invasive surgeries and complex...
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Posted by admin on Apr 30, 2017 in |
The extraction of stem bark of Terminalia arjuna using different extraction methods viz. room temperature extraction (RTE), soxhlet extraction (SE), Ultrasound assisted extraction (USAE) and microwave assisted extraction (MAE), estimation of the percentage yield of marker compounds arjunic acid and arjunolic acid present and in vitro evaluation of urease inhibitory activity of the extracts has been investigated. The quantitative estimation of the yield of marker compounds was done using HPTLC using standard plot technique. The molecular docking of the marker compounds was performed on urease 3LA4 enzyme protein. The in vitro urease inhibitory activity of the extracts was performed spectro photometrically taking thiourea as standard. The percentage yield of the marker compounds was in order MAE>USAE>SE>RTE. The molecular docking study suggested that the arjunic acid (-55.511 Kcal/mol) exhibited better results of inhibition compared with the free energy values of arjunolic acid (-40.765 Kcal/mol) and standard thiourea (-25.846 Kcal/mol). The in vitro urease inhibitory activity of the extracts also followed same pattern as for the percentage yield of the marker...
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