Posted by admin on Mar 31, 2017 in |
Norepinephrine (NE) is an important catecholamine neurotransmitter that acts as a biochemical messenger in central nervous systems and neuronal cells of mammals, which is secreted and released by the adrenal medulla and the noradrenergic neurons during the synaptic transmission. It is often used for treating bronchial asthma, myocardial infarction hypertension and organic heart disease. Abnormal release of NE will contribute to the occurrence of many nerve related diseases, such as paraganglioma, ganglia neuroblastoma, ganglion neuronal, and Parkinson’s disease. In addition, increased NE concentration in plasma is associated with coronary heart disease and with muscle sympathetic nerve traffic in human obesity. Furthermore, NE is involved in the occurrence and development of cardiac hypertrophy through the activation of myocardial adrenergic receptors on cell membranes in myocardial tissue. Therefore, the rapid, sensitive, and selective detection of NE level is significant for monitoring physiological function and diagnosing diseases. In this article the studies of detection methods for NE in recent years are...
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Posted by admin on Mar 31, 2017 in |
Among adults in India, Chronic myeloid leukemia (CML) is most common leukemia and accounts for 30% to 60% of all adult leukemias. Imatinib mesylate induces the highest rate of complete hematological and cytogenetic responses, but its efficacy is still debated in different sets of patients. Total 50 newly diagnosed patients of CML were enrolled. Patients receiving imatinib 400mg orally daily were monitored carefully for haematological changes and changes were noted at 3, 6 and 9 month. Patients were categorized on the basis of age and gender, and hematological and cytogenetic responses were compared. Cytogenetic studies were done at 6 months to ascertain the response. Imatinib produced >80% response in various hematological parameters in different groups of patients. Younger age group and male patients shows better hematological as well as cytogenetic response at 6 months. Older age group and female patients shows poor responses in comparison to younger age group and male patients of CML. Further study on large samples of CML patients is advised to search out the possible...
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Posted by admin on Mar 31, 2017 in |
Both diabetes mellitus and cancer are characterised by higher levels of oxidative stress and production of free radicals, which further complicate the control and outcomes of these diseases. The aim of this study was to assess the level of urinary 8-Hydroxydeoxyguanosine in diabetic cancer patients as a biomarker of cellular oxidative stress for both disease progression and chemotherapy administration. A controlled prospective observational study carried out on 100 diabetic patients newly diagnosed with diverse cancer types eligible for different chemotherapeutic protocols at the oncology unit. Urinary 8-Hydroxydeoxyguanosine level assessed at the baseline (before the required chemotherapy protocol schedule), and the 2nd reading (at the end of the required chemotherapy protocol schedule). Results showed that there was a significant (p<0.05) increase the urinary 8-Hydroxydeoxyguanosine level between the baseline and 2nd readings (27.04±4.33 ng/dl) vs (30.77±4.63ng/dl), and between the baseline and 2nd readings at 7-day course (25.96±4.21ng/dl) vs (28.16±5.27ng/dl), at 14-day course (27.76±5.33 ng/dl) vs (31.56±4.47ng/dl), and at 21-day course (27.22±4.16 ng/dl) vs (31.40±4.24ng/dl). In conclusion, this study presented that oxidative...
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Posted by admin on Mar 31, 2017 in |
Vascular endothelial growth factor receptors (VEGFR) are kinase based receptors reported as a promising target in anti tumour therapy. VGEFR inhibitors are being investigated which can have important contribution in anti-angiogenic therapy for treatment of cancer. In the present study, an attempt has been made to develop a site-specific QSAR model in order to explore the definite sites of substitution of a series of 4-thiazolidinone derivatives having reported antitumor activity against h460 cell lines. Each molecule of the series was divided into seven fragments for varying substituent at the positions R1, R2, R3, R4, R5, R6 and R7 of the parent nucleus. GQSAR was performed using MLR, PCR, PLS and KNN methods of variable selection. Amongst these methods, PCR has come out with promising result as compared to other methods. A comparative docking study was performed to explore the particular sites of interactions within the binding cavity of VGEFR protein. (PDB id: 1Y6A). The important substitutions contributing towards the biological activity by interpreting the developed GQSAR equation using virtual...
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Posted by admin on Mar 31, 2017 in |
N-mannich bases of benzimidazole derivatives can work against convulsions. Docking used for virtual screening of database and for the prediction of the strongest binders based on various scoring functions. Docking studies were carried out on different benzimidazole derivaties for better anticonvulsant activity which is important for the development of new class of inhibitors. Protein–ligand interaction plays an important role in structural based drug design. In our research we selected different receptors. The receptors were docked with different imidazole derivatives and the energy values were obtained. Our study reveals that highest minimal energy values were observed with receptors like 4NF8, 4JWY, 4JWX, 3QEK, 3OEK, 3OEL, 3OEM, 3OEN. The results suggests that N-mannich bases of benzimidazole derivatives might be a potential targets of NMDA receptors for effective anticonvulsant...
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