Posted by admin on Jan 31, 2018 in |
This study evaluated the anticonvulsant effect of different extracts of Centella asiatica (CA) with particular reference to lipid metabolism in different regions of rat brain. The rats were randomly divided into 4 groups having 6 in each group: i.e. Control group received saline, PTZ-induced epileptic group (60mg/kg b.w op/ 1 day), epileptic group pretreated with chloroform extract (CE), epileptic group pretreated with aqueous (AE) extract and epileptic group pretreated with diazepam (DP; Reference control) (2 mg/kg b.w/ip/ day). The CA extract is administered at the dose of 200 mg/kg body weight orally for one week. The experimental results were observed that the decreased content of phospholipids in the entire brain regions i.e. Cerebral cortex (CC), Cerebellum (CB), Hippocampus (HC) and Pons medulla (PM); total cholesterol, triglycerides and increased content of Lipid peroxidation in epileptic rats. The reversal changes were observed on pre treatment with the chloroform extract of CA and diazepam. Hence, it is evident that the different bioactive factors of CA offered protection against PTZ-induced...
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Posted by admin on Apr 30, 2016 in |
Cellulite is a normal condition judging from the medical aspect, but from aesthetics aspect, cellulite deserves more attention, especially for women. Centella asiatica is reported to promote both fibronectin and collagen synthesis. Meanwhile, Zingiber officinale is reported to have lipolysis activity. Combination of the two herbals is assumed to have complementary effect as anti cellulite agents. The combination of the herbal extracts is prepared in nanoemulsion form to enhance the bioavailability. The study aimed to determine the effect of nano emulsion of C. asiatica and Z. officinale combination (proportion of 5:1) to stimulate skin collagen synthesis and decrease the diameter of adipocyte cells using histological parameters as an indicator of lipolysis activity. Twenty female Wistar rats weighing 120-140 g were fed a high-fat diet for 30 days. The animals were divided into 4 groups, with the 3 groups received the nanoemulsion of herbal combination with the dose of 50, 100, and 200 mg/kg BW for 30 days, and 1 group received CMC Na 0, 5% as negative control. On...
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Posted by admin on Sep 1, 2012 in |
The methanol extract of Centella asiatica (Family:Umbelliferae) was studied for its phytochemical and pharmacological Activities. This study of the extracts indicates the presence ofReducing Sugar Tannins, Alkaloids, Sapponins and.The pharmacological study include Antimicrobial activities.The extract of the plant showed activity against a wide a variety of microorganism’s .All the activities were compared by measuring the zone of inhibition with the standard antibiotic. Based on the findings of Antimicrobial activity, we can say that the plant may contain novel compounds that possess potent anti-mutagenic activity and anti-oxidative activity. The obtained results support for the uses of this plant as traditional medicine. Infectious diseases are the second leading cause of death worldwide. Treatment of infections continues to be problematic in modern time because of the severe side effects of some drugs and the growing resistance to antimicrobial agents. The activities observed could be attributed to the presence of some of the phytochemicals detected which have been associated with antibacterial...
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Posted by admin on Apr 30, 2025 in |
In an increasingly fast-paced world, the rising prevalence of anxiety and mental health disorders highlights the critical need to preserve cognitive well-being. While mental illnesses often result from complex biological, psychological, and environmental interactions, their precise origins remain elusive. Conventional medicine offers various treatments, but alternative approaches, like nervine tonics, are garnering attention for their natural, therapeutic potential in supporting the nervous system and promoting relaxation. This study introduces Neuragreen, a novel polyherbal nervine tonic designed to enhance blood circulation, regenerate nerve cells, and exhibit potent nootropic, anti-Alzheimer, anti-depressant, and antioxidant effects. The formulation blends powerful herbal ingredients, including Ginkgo biloba, Centella asiatica, Bacopa monnieri, Withania somnifera, Mucuna pruriens, Pueraria tuberosa, Convolvulus pluricaulis, Celastrus paniculatus, Beta carotene, and B-complex vitamins. A multidisciplinary approach was employed, utilizing LCMS, UV-Visible, and FTIR spectroscopy, along with antioxidant assays and molecular docking. LCMS identified diverse bioactive compounds, while UV-Visible spectroscopy revealed the presence of flavonoids, terpenes, and alkaloids. FTIR confirmed the presence of polyphenolic compounds with antioxidant potential, and terpenoids were also detected....
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Posted by admin on Mar 31, 2023 in |
Neurodegenerative diseases (NDs) that are characterized by progressive loss of functioning and structure of neurons are of great burden to the individuals and the society. With several hypotheses, the existent cause still remains a mystery for various NDs in healthcare. Protein degradation, inflammation, oxidative stress, environmental factor, mitochondrial defects, abnormal protein accumulation in neuron and familial history are amongst the commonly studied environmental causative factors for NDs. These disorders are a significant cause of disability and mortality, and consequently increasing life spans is one of the key challenges for medical research. The excessive treatment cost has led the world to move to alternative therapy with lower cost and minimal side effects compared to conventional treatments. Medicinal plants have been used for treating various diseases since ancient times in India. Medicinal plants used in Unani System of Medicine cover most of the NDs. It has defined a huge number of plants with multiple therapeutic benefits. In this review, the role of important medicinal plants, viz., Prunella vulgaris L., Melissa officinalis...
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