Posted by admin on Jan 31, 2023 in |
Compounds with heterocyclic moiety are important for life and are abundant in nature. Heterocyclic compounds have a crucial part in the metabolism of all biological cells. Humanity relies heavily on nitrogen-based heterocyclic compounds. Benzimidazole, in particular, is a vital component of the entire nitrogen-based heterocyclic chemical family, not just physiologically but also industrially. Because once benzene, as well as imidazole, get merged around each other, a heterocyclic benzimidazole compound forms. Benzimidazole incorporates two nitrogens like a heteroatom. Benzimidazole analogues are often more powerful, medicinally significant chemicals with a wide range of biological activities. Benzimidazole analogues have been proven to be beneficial in several fields. The medicinal characteristics of benzimidazole analogue are diverse, including anticancer, antidiabetic, antihypertensive, and antimicrobial properties. Because of the medications’ uses in the treatment of microbe-related infections and other biological activities, stronger and more significant pharmaceuticals are being developed. These compounds have been found to be efficient against various bacteria in pharmacological tests. The antimicrobial property of several benzimidazole compounds is summarised in this...
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Posted by admin on Dec 31, 2022 in |
Begonia cucullata Willd. (Begoniaceae) is a native medicinal species from Paraguay popularly used to combat stomatitis, pharyngitis, respiratory ailments in children, and inflammatory conditions among others. The limited literature did not report these plants as having analgesic, anti-inflammatory, or antimicrobial properties. This work aims to determine the acute toxicity, general behavior, analgesic, and anti-inflammatory activities in mice and antimicrobial activity in-vitro of crude extract of B. cucullata (CEBc). Experimental induced-pain models (Randall-Selitto, Writhing, and Hot plate test) were used for the study of analgesia in mice. Likewise, carrageenan-induced paw edema was used to evaluate the anti-edematous activity of CEBc. CEBc is safe, well-tolerated, and without behavioral effects in mice and is devoid of antibacterial activity. Using the Randall-Selitto method, oral doses of CEBc denoted a significant increment in the pain threshold up to 260 %. Also, in the writhing test, the number of abdominal contortions was significantly decreased up to 68% by CEBc in a dose-dependent manner in comparison to the control group. Likewise, oral administration of CEBc in...
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Posted by admin on Dec 31, 2022 in |
The present research aims to synthesize novel 5, 6-dihydro-3-(substituted phenyl) [1, 2, 4] triazolo (3, 4-b) [1, 3, 4] thiadiazine-7-one derivatives and their physiochemical evaluation for antibacterial and antioxidant activities. Novel synthetic schemes were designed to synthesize compounds (1-6), which were then characterized using physicochemical and spectroscopic methods (IR, 1HNMR). In-vitro antimicrobial activity was performed against Gram-positive (Staphylococcus aureus, Bacillius subtilis), Gram-negative (Escherichia coli) bacterial strains and fungal strains (Aspergilus niger, Candida albicans) of all synthesized compounds. In addition, Minimum inhibition concentration (MIC) and Minimum fungicidal concentration (MFC) values were determined using tube dilution methods using standards such as norfloxacin and fluconazole. The free radical scavenging activity was also assessed using the DPPH assay, with vitamin C serving as a reference molecule. Compound 3 was discovered to have the best antibacterial activity (IC50– 80.27) of all the compounds, while the rest compounds showed modest scavenging...
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Posted by admin on Nov 30, 2022 in |
Nanoparticles are fascinating materials that find many applications in basic and applied research. The chemical reduction technique is one of the easiest methods for synthesizing Nickel Oxide Nanoparticles (NiO NPs) in low-temperature ranges. Nickel Nitrate Hexahydrate (Ni(NO3)2.6H2O), Ascorbic acid, NaOH, and NaBH4 were applied as starting reagents to synthesize NiO NPs. Noble metal oxide nanoparticles have been extensively utilized for many applications in the present scenario. In the present study, attention has been focused on the fabrication of NiO NPs synthesized by the Chemical Reduction Method (CRM). The synthesized nanoparticles were characterized by UV-Vis spectroscopy, FTIR spectroscopy, X-ray diffraction, EDAX, and SEM Techniques. The optical band gap energy value has also been determined as 2.59eV from the UV-Vis spectrum. The nanometal oxide is subjected to photocatalytic activity on Congo red dye under solar irradiation and exhibits very good degrading ability within a few minutes of exposure. Its pharmacological activity is also analyzed using pathogenic organisms like Staphylococcus aureus, Bacillus subtilis, Escheria coli, and Pseudomonas aeruginosa bacteria and found to...
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Posted by admin on Sep 30, 2022 in |
Quorum sensing is a peculiar mechanism of microbial communication through the induction of various signalling autoinducer molecules having several gene expression regulatory activities of different virulence factors that control microbial. This enables a systematic path of inhibiting microbial growth and its infection production efficacy by indirectly regulating the Quorum sensing activity of the concerned pathogens. As antimicrobial resistance directly impacts the healthcare system, hence is one of the biggest threats to global health. The attenuation or inactivation of these resistant variety bacteria is the utmost call of hour. In this panorama, interference/change in the chemical signal of QS system has been developed as an efficient technique to block their expression, hence enabling them as less virulent. A literature study was performed using online research, including database searches such as PubMed, SciELO, and SCOPUS between 2000-2020. This review aims to provide a brief mechanism of inhibition of microbial resistance through QS system by different...
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