Posted by admin on May 31, 2020 in |
Ageratina adenophora, often known as Crofton Weed, is one of the common invasive weeds which first originated from Mexico and Central America and gradually invaded numerous parts of the world. Because of its ability to alter the soil microbial communities and its allelopathic competition with other plant species, this plant colonizes forest margins, stream banks and disturbed areas in large dense clumps and is found to possess potent toxicological effects on livestock; the lethal chronic pulmonary disease has been reported in horses while liver complications have been reported in mice. Despite this, the plant has been studied more extensively for its therapeutic uses as phytochemicals viz. steroids, tannins, triterpenes, coumarins and saponins (7-hydroxy-dehydrotremetone, 7, 10,1 1-trihydroxy-dehydrotremetone, 10-oxo-7-hydroxynordehydro-tremetone,Eupatorone, 2-deoxo-2-(acetyloxy)-9-oxoagera-phorone(DAOA), 9-oxoagerophorone(OA), etc.) which have been reported are found to possess antimicrobial activity, antipyretic activity, wound healing, antioxidant activity, analgesic activity, anti-tumor activity, insecticidal activity, antiviral activity, anti-inflammatory activity, larvicidal activity. This present review is an effort to give a detailed survey of the literature on invasive nature, pharmacological study, phytochemical review,...
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Posted by admin on Apr 30, 2020 in |
Consumption of fresh leafy vegetables by a street vendor cause salmonellosis is a major public health problem worldwide. The aim of the study to investigate total microbial count and the occurrence of ESBL producer and antimicrobial resistance pattern of Salmonella from fresh leafy greens. In this sample Salmonella spp. Population ranged from 40.33 to 35.33 × 102 CFU/g of fresh samples. The highest Salmonella spp. The population was observed in 40.33 × 102 CFU/g in green leaf, followed by Coriander and Ponnankanikirrai (red). Among the 10 isolates, five (50%) isolates namely NS-1, 2, 4, 5, and 7, could be ESBL producers by double-disc synergy test. From the 5 Salmonella spp., 4 isolates (88.89%) were resistance to cefuroxime and cefixime, 3 isolates (77.78%) resistant to ceftazidime and cefdinir, 2 isolates (33.33%) resistant to amoxiclav ceftriaxone and co-trimoxazole, and 1 isolate (11.11%) resistant to cefixime, amikacin, and chloramphenicol. Citric acid eradicated the Salmonella spp. averagely 100% at 3% concentration while 9.77 (0.5%) to 93% (2.5% concentration) from control. Acetic acid (3...
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Posted by admin on Apr 30, 2020 in |
Heterocyclic systems are a part of a large number of drugs and biologically relevant molecules. The chemistry and biological study of heterocyclic compounds have been an interesting field for a long time, and oxazole is one such moiety that has gained attention in recent times due to its increasing importance in the field of medicinal chemistry. Oxazole is a doubly unsaturated five-membered ring having one oxygen atom at position 1 and nitrogen at position 3 separated by a carbon atom in between. The substituted pattern in oxazole derivatives play a vital role in delineating the biological activities like antimicrobial, antifungal, antitubercular, anticancer. The utility of oxazole as intermediates for the synthesis of new chemical entities in medicinal chemistry has been increased in the past few years. Oxazole is an important heterocyclic nucleus having a wide spectrum of biological activities, which drew the attention of researchers around the globe to synthesis various oxazole derivatives and screen them for their various pharmacological activities like antimicrobial activity, antitubercular activity, anticancer activity. 6-(substitutedbenzylidene)-2-methylthiazolo...
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Posted by admin on Apr 30, 2020 in |
In the present investigation, some novel Mannich Bases of Pyrazoline derivatives(7a-g) is synthesized by treating various substituted acetophenones (1a-g) with 6-methaoxy-1-napthaldehyde (2) in alcoholic sodium hydroxide to obtained intermediate Chalcones (3a-g), which was further treated with isonicotinohydrazide (4) to get (3-(4-substituted phenyl)-5-(6-methoxy naphthalen-1-yl)-4, 5-dihydro- 1H-pyrazol-1-yl) (pyridin-4-yl) methanone (5a-g). Further, it is refluxed for 6-10 h. with 4-chloroaniline (6) and formaldehyde in methanol to afford Mannich Bases i.e. (4-(((4-chlorophenyl) amino) methyl) -5-(6-methoxynaphthalen -1-yl)-3-substituted phenyl-4, 5-dihydro- 1H-pyrazol-1–yl )(pyridin-4-yl) methanone (7a-g). The structure of synthesized Mannich bases was confirmed on the basis of Spectral data (IR, 1H NMR, mass, and elemental analysis) and evaluated for the antimicrobial activity. The antimicrobial data revealed that the synthesized derivative possesses very promising to moderate antibacterial and antifungal...
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Posted by admin on Mar 31, 2020 in |
Nanoparticles are widely used in different technological fields, one of which is medicine. Collagen is used in several types of wound dressing. A silver nanoparticle is used as an antimicrobial agent to reduce microbial infection. In this research work, we have synthesized silver nanoparticles with collagen and studied for antibacterial activity against aureus (S. aureus), Escherichia coli (E. coli), and Pseudomonas aeruginosa (P. aeruginosa). The silver content and cell line study results reveal that the formulation contains less concentration of silver (0.109 µg /ml), and it is not toxic in 3T3 cell lines. Antibacterial activity of collagen-based silver nanoparticle formulation (F7) was found to be high against S. aureus, E. coli, P. aeruginosa when compared with silver nanoparticles...
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