Posted by admin on Sep 30, 2019 in |
Background: Garlic has been used in world culinary art as well as in herbal medicine since long back. Allicin, an active moiety in garlic, is truly recognized as heart of garlic. But allicin is highly unstable and undergoes formation of numbers of sulfur-containing compounds with reduced allicin content. The major problem associated with dosage form development is instability of allicin. Objective: The aim of the present research work was to obtain a stable garlic powder from the garlic bulbs with maximum allicin content with prolonged physical and chemical stability of the garlic powder. The target was to improve household storage for culinary purpose as well increased active drug content proclaimed for long term utilization in dosage form design. Methodology: The principles of microwave drying technology and the flower drying technology along with some modifications have been successfully utilized for preparing, processing and preserving garlic powder to improve its medicinal and culinary acceptance. Results: The allicin content was found to be increased (2533.7 µg/gm) as compared aqueous garlic extract and...
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Posted by admin on Sep 30, 2019 in |
Background: The irrational uses of antibiotics play a crucial role in emerging of antimicrobial resistance. So regular review of the prescribing patterns represents an effective monitoring study that enhances rational prescription of antibiotics. This study evaluated the prescribing pattern of antibiotics at Al-Rass hospital in Qassim region. Methodology: A retrospective cross-sectional study was approved by the Regional Research Ethics Committee and conducted at Al-Rass hospital. A total of 3595 emergency prescriptions and 1203 from in-patient were evaluated, and only 177 antibiotics prescriptions were included in the study. Descriptive statistics were used in the analysis of data. Results: Among 240 antibiotics prescribed in 177 prescriptions, 58.7% were for female. Antibiotics were commonly prescribed for upper respiratory tract infections (URTI) in 26.6% and lower respiratory tract infections (LRTI) in 16.4%. The most commonly prescribed antibiotic was amoxicillin/clavulanate (26.9%), and it was mostly prescribed for URTI. The second antibiotic was ceftriaxone (25.2%) with high prescription in obstetrics and LRTI. For surgical prophylaxis metronidazole was mostly prescribed (5.5%), followed by ceftriaxone (4.3%). Paracetamol...
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Posted by admin on Sep 30, 2019 in |
Calcium oxide nanoparticles (CaO NPs) gain great value in the areas of energy storage and drug delivery systems. Due to good porosity, it finds its part in storage systems and its biocompatibility earns it a good value in drug delivery and gene transfection. Synthesis of nanoparticles by waste materials and plants of metal oxide is gaining considerable interest due to environmentally friendly reactants and room temperature synthesis. This is most using method of preparation of nanoparticles as it makes use of pollution-free chemicals and encourages the use of non-toxic solvents such as water and plant extracts. In this present study, the calcium oxide nanoparticles synthesized by the eco-friendly green synthesis using environmentally begin waste chicken egg shells. CaO nanoparticles show better antibacterial activity. CaO was bio modified by Cissus quadrangularis, Acalypha indica, Solanum nigrum, Phyllanthus niruri to enhance the antibacterial activity, then the antibacterial activity of pure CaO and bio modified CaO was investigated against B. substilis, S. aureus and E. coli species. The synthesized nanoparticles have been characterized...
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Posted by admin on Jul 31, 2019 in |
Klebsiella pneumoniae is a significant pathogen for nosocomial infections and quickly becomes the most prevalent beta-lactamases produced that are resistant to several antimicrobials. To comprehend deeper the condition of multidrug resistance [MDR]. Objectives: Our research was directed at identifying Klebsiella pneumoniae isolates containing shv β-lactamase gene and the relationship between them and some antimicrobial resistance in order to prevent rejection of therapy. Methods: Overall, 64 K. pneumonia it gathered pneumonia isolates and conducted a drug susceptibility test for 13 different antibiotics by the system Vitek 2 to identify their susceptibility patterns. Phenotypic tests for species producing ß-lactamase have determined the resistance phenotype of isolates. Results: The information indicated that 60[93.7%] of the entire isolates tested were Shv genes, while the remainder were positive. The PCR was used to amplified drug resistance. Highest antibiotic resistance in instances of ESBL positive. In fact, 2[33.3%] of the phenotypical confirmatory Test [PCT] sample were shown to be negative isolates. The data has shown that prediagnosed positive phénotype isolates were genetically positive for EsBL development. Concept: the...
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Posted by admin on Jul 31, 2019 in |
Objective: To evaluate the antimicrobial potential of Nocardiopsis flavescens isolated from the marine environment. Methods: Attempts were made to isolate actinomycete strains from marine coastal regions of Andhra Pradesh, India. The soil samples collected were pre-treated with calcium carbonate, diluted and plated on three different media to isolate actinomycetes. All the isolates were screened for antimicrobial activity by using the Kirby-Bauer disc diffusion method. Among the fifty isolates screened, one potent strain designated as VJMS-18 exhibited high antimicrobial activity. The isolate was identified by using micro-morphological, cultural, biochemical, physiological and molecular approaches. Results: The Potent strain was identified as Nocardiopsis flavescens VJMS-18. It showed good growth on YMD agar amended with 3% NaCl. Growth pattern of the isolate was studied by culturing it in YMD broth. The culture broth was extracted with ethyl acetate and tested for antimicrobial activity. It exhibited high antimicrobial activity against gram positive and gram negative bacteria as well as fungi. Conclusion: The present investigation reveals that Nocardiopsis flavescens VJMS-18 isolated from the coastal environment...
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