Posted by admin on Mar 31, 2019 in |
Heterocyclic chemistry plays a very most important role in medicinal chemistry as well as in organic chemistry. Most of the drug molecule formed and possesses therapeutic activity due to the heterocyclic scaffold. A slight change in heterocyclic moiety leads to the major therapeutic change in the drug molecule. Benzothiazole can serve as a unique and versatile moiety for experimental drug design. Benzothiazole and its derivatives are the essential chemical compounds with tremendous application in research area especially in synthetic as well as in pharmaceutical chemistry because of its potent and significant pharmacological activities. As we know that benzothiazole is a combination of two rings six-membered and five-membered and it is also known that both rings are responsible for the therapeutic activity. The main objective of our study is to find what changes lead to a better corrective benzothiazole shift moiety. A well-known approach to design new drug-like molecules, which allows achieving new pharmacological profile, action, toxicity lowering, is the development of a combination of 2- aminobenzothiazoles with another heterocyclic...
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Posted by admin on Mar 31, 2019 in |
Objective: The objective of this research was a synthesis of silver nanoparticles from Murraya koenigii leaves in which the particles were characterized by various techniques and to evaluate the potential antibacterial activity of synthesized nanoparticles against various human pathogens. Methods: Murraya koenigii aqueous extract of leaves were prepared by the Soxhlet method, and the bioactive compounds were analyzed by phytochemical analysis. Silver nanoparticles were synthesized which are characterized by UV-visible spectroscopic analysis, XRD, TEM, FTIR analysis and antimicrobial activity was evaluated by agar well diffusion method. Results: Phytochemical analysis of Murraya koenigii aqueous extract of leaves showed the presence of alkaloids, phenols, flavonoids, terpenoids, coumarins, and steroids. The aqueous AgNo3 solution changed from green to dark brown color after incubation. UV-visible spectroscopic analysis showed the absorbance peak at around 420 nm which indicates the synthesis of Ag NPs. TEM image showed the formation of well-dispersed silver nanoparticles in the range of 5-25 nm. X-ray diffraction (XRD)-spectrum as evidenced by the peaks at 2θ values of such peaks 38.43°, 44.40°, and...
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Posted by admin on Mar 31, 2019 in |
Chalcone based structures have many interesting biological properties like anti-malarial, anticancer, antiviral, antibacterial, antifungal, anti-hyperglycaemic and photo-cytotoxicity activities. In this study, the novel chalcone derivatives (1a-1l) have been synthesized and investigated for antimicrobial activities. The MIC results of antimicrobial activities reveal that one of the chalcone derivative (2-Br- and 4-OCH3– group) against specific bacteria are quite significant. 3D QSAR, three dimensional quantitative structure activity is one of the most powerful technique which involves the quantitative relationship between the biological activity of a set of compounds and their three dimensional structural properties, using statistical correlation methods. Pharmacophore modelling and molecular docking play an important role in drug design. To elucidate the relationship between structures and its activity, field-based 3D QSAR analysis has been carried out of novel chalcone derivatives. Structural properties such as electrostatic, hydrophobic, aromatic, and hydrogen-bond donor and acceptor have been worked out for novel chalcone derivatives. To investigate the influence of drugstore, chalcone derivatives (1a-1l) have docked with receptor 2IOK and results displayed the highest Gscore of...
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Posted by admin on Mar 31, 2019 in |
Biofilms are protective organic extracellular polymeric substances secreted by a microbial population which prevents the penetration of antimicrobial substances such as antibiotics. The existence of biofilms has become a significant problem in the case of infections as well as industrial processes. Although, biofilms may act as an advantage to the microbial community, they are found to cause food spoilage, unpleasant odors, pipe blockage, infections, etc. Biofilms play a crucial role in causing persistent UTIs which undergo frequent relapses, seen most commonly in women, children and aging adults. In the present investigation, bacterial samples isolated from UTI samples of infected patients were characterized. The capacity of the UTI isolates to form biofilms is analyzed using biofilm assay done by subjection of samples to primary and secondary screening by ELISA plate reader. Further on, N-acyl homoserine lactone (AHL), an autoinducer responsible for the formation of biofilms in gram-negative bacteria was extracted and estimated colorimetrically and spectroscopically by using Fourier Transform Infrared Spectroscopy (FT-IR). The AHL that was extracted showed a characteristic...
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Posted by admin on Mar 31, 2019 in |
Herbal drugs play an important role in the treatment of much illness. The plant has tremendous biological effects and applied in the different system of traditional medication for the treatment of various diseases. Marsilea minuta is one of the most popular foreground plants for aquariums that grows about two to three inches tall in shallow water and has attractive little markings on the tiny, variegated, green leaves. It is an aquatic or sub-aquatic fern used as a vegetable, has wide applications in traditional/folk medicine in India and Bangladesh. It is a member of the fern family. Synonyms of Marsilea minuta are Marsilea crenulata Desv, Marsilea diffusa A. Braun and Marsilea rotundata Wild. Marsilea minuta possesses many pharmacological activities such as antipyretic and analgesic, antidiabetic, antitussive, expectorant, antiamnesic, anti-aggressive, antimicrobial, hepatoprotective, antifertility, anti-tumor, antioxidant activity. This study was aimed to present an overview of traditional use, phytochemical and pharmacological investigations present in this...
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