Posted by admin on Sep 30, 2018 in |
Lamium album is used as a blood purifier, in the treatment of the respiratory tract diseases, diarrhea and bleeding. In this study antioxidants and anti-bacterial activities of its aerial parts and roots were investigated. Extracts were prepared by Soxhlet apparatus. Methanol used as extracting solvent. Phenol and flavonoids contents and antioxidant properties were evaluated by different methods. Different concentrations of extracts were used for determining the MIC. Microorganisms suspensions were prepared in Mueller Hinton broth with different concentrations of extracts and incubated for 24 h at 37 °C, the turbidity of the tubes were observed. MIC and MBC were determined. Total phenolic content of aerial and roots extracts were 242.75 ± 10.13 and 135.0 ± 8.15 and total flavonoid contents were 79.83 ± 4.22 and 30.33 ± 1.08 QE respectively. The DPPH radical-scavenging ability of extracts were 238.4 and 257.0 µg/ml respectively. Reducing power of both extracts increased by increasing the concentrations. The amount of scavenging nitric oxide at the 1600 mg/ml, was 58 and 68%, respectively. IC50 for...
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Posted by admin on Sep 30, 2018 in |
Papaya (Carica papaya Linn.) is well known for its nutritional as well as medicinal value since long time. The medicinal properties of fruit and other parts of papaya are well known in the different system of traditional medicine including Ayurveda. Its various parts has been reported for various disease conditions viz. fever, swellings, jaundice, gonorrhea, bilious fever, itches, eczema, and rheumatism cold, headache, whooping cough, asthma, chicken pox, and bronchitis in various traditional literature. The various remarkable researches on biological activities and medicinal application have been reported during past four decades and established it as an important nutraceuticals agent. Carica papaya Linn. leaf has been scientifically studied for various therapeutic activities like antibacterial, antioxidant, antipyretic, insecticidal, antimicrobial, anti-molluscal etc. In view of this leaves have been explored through several advanced techniques like phyto-extraction of heavy metals, phytoremediation of particulate pollution and many others. Various studies on phytoconstituents and chemical composition of leaves have been reported in last few decades. The present review aims an exploration of pharmacognostical, phytochemical and...
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Posted by admin on Sep 30, 2018 in |
Antibiotic resistance continues to pose a significant problem in the management of bacterial infections despite advances in antimicrobial chemotherapy and supportive care. Therefore, it is necessary to search the other alternatives that can be effective in the treatment of these infections. The present work was aimed to evaluate the antibacterial and antibiotic-potentiation activities of lemon against drug resistant phenotypes. The sensitivity of S. aureus and P. aeruginosa was determined by performing antibiotic sensitivity test (AST). They were found to be resistant to tested antibiotics and since S. aureus was resistant to oxacillin it was classified as methicillin resistant S. aureus (MRSA). The phytochemical analysis of lemon juice and lemon peel extract showed presence of flavonoids, phenols, steroids, reducing sugar and alkaloid. Antioxidant activity which was determined by Ferric Reducing Antioxidant Power (FRAP) assay method showed increasing trend in reducing power with the increase in concentration for both samples. The antibacterial activity of lemon juice, lemon peel extract and citric acid was screened against resistant isolates by using agar well...
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Posted by admin on Aug 31, 2018 in |
Effervescent tablet is a convenient oral dosage form, which has special ingredients. This potency of effervescent tablet helps to delivered drugs, effectively. Medicinal plants have a wide range of usage in the world. Mespilus germanica (Rosaceae) and Quercus castaneifolia (Fagaceae) are important medicinal plants used in several diseases such as diarrhea. Medlar and oak, the fruits of M. germanica and Q. castaneifolia respectively, were harvested and extracted using hydro-acetonic solvent by maceration method. In addition, total phenol and tannin contents were assayed using Folin-Ciocalteu method. Antimicrobial activity of extract was determined using broth dilution test on some intestinal pathogens. Finally, effervescent tablets were prepared using wet granulation method and analyzed. Total phenols and tannins were obtained 0.9% and 0.1% respectively. This reduces the amounts of total tannins will disappear with adding antioxidant agents. Tablet hardness, friability and disintegration time were significantly dependent on the amounts of lubricant, acidifying and alkalizing agents. This work investigated the potential of developing Oak and Medlar effervescent tablets to facilitate drug administration and mask...
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Posted by admin on Aug 31, 2018 in |
The present work aims to design, synthesize some novel benzimidazole derivatives and to perform in-vitro evaluation of their antitubercular and antimicrobial activity. In-silico modelling of benzimidazole derivatives was carried out using various softwares such as, ACD Labs Chemsketch, Molinspiration, PASS (Prediction of activity spectra for substances) and Schrodinger Glide XP (Grid based ligand docking with energetics). Nine derivatives (BI 1a, 1b, 1c, BI 2a, 2b, 2c and BI 3a, 3b, 3c) were designed. The designed molecules with required physicochemical properties, drug likeness and obeying Lipinski’s rule of five were selected for the synthesis. The synthesized compounds were subjected to TLC, melting point determination, FTIR and mass spectral studies. All the synthesized compounds showed characteristic peak in FTIR and Mass spectroscopic studies. As per the PASS score and GLIDE score the compounds were selected for biological studies like antitubercular, antibacterial, and antifungal activity. These results are useful for further investigation in the future. All the selected derivatives showed better activity, when compared with standard...
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