Posted by admin on Nov 30, 2018 in |
The application of medicinal plants such as Terminalia arjuna to maintain health and treat disease started since time immemorial and still is a part of medical practice. The phytochemical analysis of bark of T. arjuna in methanolic, hydromethanolic (1:1), aqueous and petroleum ether extracts revealed the presence of carbohydrates, amino acid, alkaloids, saponins, tannins, flavonoids, terpenoids, glycosides, xanthoproteins and phenols. In-vitro antioxidant capacity by linear regression analysis was measured by assaying DPPH radical and H2O2 scavenging capacities. Their respective IC50 values were found to be 336.89 μg/ml and 253.01 μg/ml. The hydromethanolic extract gave total phenolic, total flavonoids and FRAP values of 754.16 ± 16.26 mg GAE/g, 247.02 ± 8.81 mg/g QE/g and 1.36 ± 0.03 mM FeSO4 respectively. The IC50 values for in-vitro anti-inflammatory activities were evaluated by the following assays: lipoxygenase inhibition (IC50 = 480.5 μg/ml), heat induced protein denaturation (IC50 = 282.32 μg/ml), proteinase inhibition (IC50 = 1339.3 μg/ml) and RBC membrane stabilization (IC50 = 192.81 μg/ml) at different concentrations using aspirin as control. Studies were...
Read More
Posted by admin on Nov 30, 2018 in |
In the field of the preparation of chemotherapeutic agents with new mechanism distinct from currently approved drugs is important. However, the clinically effective approved small inhibitor molecule is still lacking. Previous reports indicated that 4-aryl-2-hydrazinothiazole derivatives provided a useful start point to develop HAT inhibitors (histone acetyltransferase). Consequently, preparation and biological evaluation of a focused library of 4-aryl-2-hydrazinothiazole based derivatives as useful as anti-cancer agents. Synthesis of 4-aryl-2-hydrazinothiazoles (1a-d), (2a-d), (3a-c), (4a-b), (5a-b), (6a-b) studied by either conventional method and free solvent microwave one-pot method, and the synthesized compounds were proved by spectroscopic methods (IR, 1HNMR, 13CNMR, GC-Ms, and elemental analysis). The activity against different cancer cell lines and the antimicrobial activities different organisms also studied, and all of the synthesized compounds were of high activity as an antibacterial for gram positive and gram negative; however, it showed also an antifungal activity were the most active compounds were 4a, 4b, 5b, 6a. It was found that all of the prepared thiazoles derivatives were active toward many cell lines (breast,...
Read More
Posted by admin on Nov 30, 2018 in |
Quinolones are the organic compounds that act against the DNA-gyrase enzyme, a type II topoisomerase. Norfloxacin is one such quinolone which is characterized by a piperazinemoiety at C-7 position. This moiety plays a significant role in determining the antibacterial spectrum and potency and serves as a site amenable to significant modification. N-Mannich bases have proved to be potential prodrug candidates for amides, urea derivatives, imides and amines. It has proved to be a versatile base in current applications of organic chemistry. Mannich bases with N-4 substituted piperazine containing moieties were biologically active. We designed and synthesized new series of Mannich bases of Norfloxacin by conventional as well as microwave method by reacting them with isatin and various aromatic aldehydes. Their chemical structures have been confirmed by IR, 1H NMR and 13C NMR spectroscopy and evaluated for antibacterial activity by Agar well diffusion method. Antimicrobial evaluation was done against gram positive bacteria B. subtilis and gram negative bacteria E. coli. Among the compounds tested, 7a (i) and 7b (i) showed...
Read More
Posted by admin on Oct 31, 2018 in |
Encapsulation of thymol is important for its volatile nature, taste, and antispasmodic, antioxidant, antimicrobial, anticancer and anti-inflammatory properties. This review provides a summary of thymol encapsulation in different biodegradable polymers along with the methods of encapsulation and control release in various parts of the body. Biodegradability of shell material along with its health compatibility and the half life of the core material and knowledge of microstructure are some of the main issues that must be addressed while studying encapsulation of Pharmaceutically Active Ingredients (PAI). Different biodegradable polymers used for the encapsulation of thymol are xanthum gum, poly vinyl alcohol (PVA), gelatine, starch, sodium alginate and ethyl cellulose. Preparative conditions, such as concentration ratios, temperature, stirring speed, and nature of solvent used, have deterministic effect on the polymer shell formed around the core material. Purposes for encapsulation of PAI may be numerous, such as controlled release, targeted controlled release, protection/preservation, economic utilization, convenient packaging, and clever option for storage, easy portability and formulation, modification/ hiding undesirable property such as taste,...
Read More
Posted by admin on Oct 31, 2018 in |
Plants are an important source of substances which are claimed to induce biological activities. Although there are a few studies on antimicrobial and antioxidant activities of this plant, antimutagenic activity has not been studied and there is no study in Turkey. Antibacterial activities of Syzygium aromaticum against oral pathogens have not been reported until today. The scope of this work was to investigate the biological activities of S. aromaticum different extracts. The various extracts were screened for antibacterial activity. The bacteria were isolated from oral flora by traditional methods. The plant extracts were tested by Kirby-Bauer method. Other antibacterial activities tests are MIC (minimum inhibitory concentration) and MBC (minimum bactericidal concentration). In addition to, the antioxidant activities of plant extracts were screened by the stable DPPH (2, 2-diphenyl- 1-picrylhydrazyl hydrate) free-radical. The antimutagenicity of the plant extracts were determined by Ames test using Salmonella typimurium strains. The highest antibacterial activity was determined as 20 mm inhibition zone from methanol extracts. The highest DPPH scavenging activity was found as 82%...
Read More
