Posted by admin on Sep 30, 2017 in |
Modification of a drug molecule of a series having optimal activity is widely used and continues to be an important factor necessary for new drug discovery. Infectious diseases which increase dramatically by resistant and multi resistant microbes are now a days the second major cause of death worldwide and the third leading cause of death in the developed countries. Although, the search for new lead structures for the development of antimicrobial agent is an increasingly important problem in medicinal chemistry. The treatment of infectious diseases still remains an important and challenging area of research due to multidrug resistance by microbes. The increasing incident of drug resistance in treatment of microbial diseases emphasizes worldwide need for newer antimicrobial agents. To treat these infectious diseases, a route is established to synthesize the pharmacological active novel chromone based sulfonamide derivatives i.e. substituted N- (3 –formyl -4-oxo -4H –chromen -2-yl) -N-phenyl benzene sulfonamide having antibacterial and antifungal activities. The objectives of the present work are: 1) To synthesize various derivatives of substituted N-(3-formyl-4-oxo-4H-chromen-2-yl)-N-phenyl...
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Posted by admin on Sep 30, 2017 in |
The present study instantiates the phyto-fabrication of silver nanoparticles by utilizing Petrea volubilis L. leaf broth which were instantaneously synthesised, eco-friendly, and cost-effective. The influence of physico-chemical parameters viz. contact time, leaf broth quantity, pH, temperature, and silver nitrate concentration were investigated and optimised to engineer infinitesimal nanoparticles. The SPR bands obtained from UV-vis spectroscopy confirmed the synthesis of silver nanoparticles. The active phytochemicals in Petrea volubilis L. leaf broth namely carboxylic acids, phenolic compounds and aldehydes were found to be responsible for the bio reduction and capping of silver ions according to FT-IR spectroscopy. The capping molecules of NPs were negatively charged and were passably stable as revealed by zeta potential measurements and the XRD patterns illustrated their crystallinity. HRTEM microphotographs enumerate spherical shaped nanoparticles. The EDS analysis at 2θ confirms the synthesis of elemental silver. The nanoparticles were evaluated for their antimicrobial activity. The highest anti-bacterial activity was observed against S. aureus as compared to the bacteria S. typhi and A. flavus a fungus. The leaf extract...
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Posted by admin on Sep 30, 2017 in |
Clerodendrum phlomidis is a shrub common in India and Sri Lanka. It is one of the highly traded medicinal plants from tropical forests, as the leaves and roots are used in folk-lore, Ayurveda, Siddha and Unnani medicines. In this study preliminary phytochemical screening, cytotoxic, antioxidant and GC – MS study of leaf of C. phlomidis was evaluated. Successive extraction of the leaf of C. phlomidis was carried out with 5 solvents petroleum ether, chloroform, ethyl acetate, methanol and water. Antioxidant activity was evaluated using DPPH free radical scavenging assay at four different doses of 31.25, 125, 500 and 1000 µg/mL, cytotoxic potential was studied by brine shrimp lethality assay at four different doses of 1, 10, 100 and 1000 µg/mL. GC-MS analysis of methanol leaf extract was carried out on Thermo GC-TRACE ultra version: 5.0, Thermo MS DSQ II. Phytochemical screening analysis of the extracts indicated the presence of secondary metabolites such as steroids, steroidal glycosides, phenols, saponins, coumarins, alkaloids and flavanoids. Methanol leaf extract showed significant cytotoxic potential...
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Posted by admin on Sep 2, 2017 in |
A series of new Mannich base derivatives were designed, synthesized by conventional and non-conventional microwave method, compared and evaluated for their antimicrobial and anti-mycobacterial activity. Structures of the newly synthesized compounds were assigned on the basis of elemental analysis, IR, 1H NMR, 13C NMR and mass spectral studies. The bioactive assay showed that Mannich base derivative 1c displayed encouraging anti-tubercular activity in vitro against Mycobacterium tuberculosis H37Ra using MABA method in primary screening. The antibacterial and antifungal efficacy of these derivatives using broth micro dilution method, showed potency for 1c against Escherichia coli, 1g against Staphylococcus aureus, Candida albicans and 1j against Candida albicans in comparison with reference drugs. Furthermore, docking study has been performed for three different PDBs (3JZF, 4NZ9 and 2WHF) of different strains that showed good binding interactions. Moreover, the synthesized compounds were also analyzed for ADME properties and showed potential to build up as good oral drug...
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Posted by admin on Aug 31, 2017 in |
Objective: To study prescribing pattern for acute respiratory infections in children attending outpatient department of Paediatrics, J.L.N. Hospital, Ajmer, Rajasthan. Material and Method: The study was carried out retrospectively by analyzing the copies of prescriptions of patients who had visited the O.P.D. of the paediatrics department of J.L.N. Hospital Ajmer. A total of 350 prescriptions having written diagnosis ARI/URTI/common cold were selected for study. Information on demographic profile and treatment were spread over three different age groups (i.e. Neonates: up to one month of age, Infants: 1 month to 1year and Children: 1-14 years). Each prescription then was analyzed as per objectives of study. Results: Male patients were more as compared to females and most of the patients were in the age group of 1-14 years. Antihistaminics were the most frequently prescribed class of drugs (28.52%) followed by antimicrobials (26.35%). Antihistaminics constituted 63.08% of respiratory drugs prescribed. Antimicrobials were prescribed in 86.57% of the prescriptions and Cefpodoxime was the most frequently prescribed antimicrobial agent followed by Amoxicillin-clavulinic acid combination....
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