Posted by admin on Jan 31, 2017 in |
In the present study 17 novel benzaldehyde thiosemicarbazone derivatives were synthesised using 2-methyl-3-thiosemicarbazide as the main reactant and different aromatic aldehydes. Reactions were monitored using thin layer chromatography technique and the newly synthesised derivatives were characterized by Elemental analysis, ATR and 1HNMR techniques. For antibacterial activity four bacterial strains were selected namely Bacillus subtilis (gram +ve), Staphylococcus aureus (gram +ve), Escherichia coli (gram –ve), and Pseudomonas aeruginosa (gram -ve).Candida albicans was used to ascertain the antifungal activity of compounds. Antimicrobial assay was performed using nutrient agar media for the bacterial strains and Sabouraud agar for the fungus, zone of inhibition of all the compounds which could inhibit visible growth after incubation were calculated. Four different dilutions of the test compounds were taken and compared against ciprofloxacin and fluconazole as the standard drugs. Antimicrobial assay was performed in duplicate. The test compounds were active against both gram negative as well as gram positive bacteria. Considerable anti-fungal was shown by the compounds. Antioxidant assay was performed using 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulphonic acid) or ABTS...
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Posted by admin on Jan 31, 2017 in |
1,2,3-Benzotriazole (BTA) is a heterocyclic compound with three nitrogen atoms. The enormous investigations on derivatives of benzotriazole reveals wide applicability of this molecules for tagging and delivering huge number of heterocyclic nuclei. This molecule has been used for the analytical determination of silver as well as a restrainer in photographic emulsions. The effectiveness of 1,2,3-Benzotriazole (BTA) as drug precursors have been drawing attention for a long period. The derivatives of benzotriazole act as agonists for many biologically active proteins. For instance, corozole and alizapride have the inhibitory properties against different proteins and Benzotriazole esters have been reported to work as mechanism-based inactivators for severe acute respiratory syndrome (SARS) 3CL protease. The various derivatives synthesized by different research workers showed antimicrobial activities such as antibacterial, antifungal, antiviral, anthelmintics, antiprotozoal and antimycobacterial activity. The present article throws light on the different derivatives of benzotriazole and their related biological activity, and is reported chronologically. The chronologic development in the synthesis of its derivatives and related changes in therapeutic activity opens new channels...
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Posted by admin on Dec 31, 2016 in |
Background: Antimicrobials are used for bacterial infections & has a great benefits in health related problems of human life. The main objectives of medicinal chemistry is synthesising and producing newer molecules having a valuable significant therapeutic action. Quinolones has a considerable scientific and clinical interest since their discovery. Objective: Quinolones class of drugs are useful in the treatment of serious bacterial infections thus keeping in view a potential approach is made for synthesising & characterizing of newer quinolone derivatives for their biological activity. Method: Quinolone ester was synthesised from Gould-Jacob reaction by using substituted aniline & diethylethoxymethelene malonate (EMME) Results: Solubility of all synthesised compounds were checked in various solvents & were characterized by FT-IR, 1H-NMR. Conclusion: The result of the present study thus demonstrates the anti-microbial activity against gram positive (Bacillus subtilis) & gram negative (Escherichia coli)...
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Posted by admin on Dec 31, 2016 in |
Mimusops elengi L. is an Indian origin herb used in the Unani and other traditional systems of medicine since long time. It is commonly called by the names Spanish cherry, West Indian Medlar or Bullet wood tree. This plant is frequently cultivated throughout India especially in north India for its ornamental appearance and fragrant flowers. All parts of plant such as leaf, root, fruit, seed, bark, flower of Mimusops elengi were reported for treatment of various human ailments in traditional system of medicine. Pharmacological activities like antimicrobial, antifungal, antioxidant and free radical scavenging, anti-inflammatory analgesic, antipyretic, antiurolithiatic, cytotoxic, diuretic, neuroprotective, anti-amnesic, cognitive enhancing, antihyperglycemic, antihyperlipidemic, hypotensive, antiulcer, anthelmintic, antitumor, wound healing, larvicidal activities have been scientifically evaluated for various parts of this plant. A number of phytochemical constituents have been identified in this plant that may be responsible for its pharmacological activities. So many articles are available on Mimusops elengi L., but from Unani literature the discussion is very limited. This review is an effort to summarize the detailed...
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Posted by admin on Dec 31, 2016 in |
Five novel benzimidazolium salts were synthesized as N-heterocyclic carbene (NHC) precursors (1a–e). They were characterized by different techniques. The antimicrobial activities of these compounds were tested. The compounds showed moderate activity against three Gram (+) and seven Gram (-) bacteria in comparison to tetracycline, which was used as the standard antibiotic, whereas all the compounds (1a-e) showed no activity against the test yeast C....
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